Experimental treatment of dysbiosis in colitis with hepatitis
<p>Nonspecific colitis (inflammation of the colon mucosa) is a common gastroenterological disease. The causative factors of this disease are intestinal dysbiosis, which leads to an increase in blood concentration of intestinal endotoxin (lipopolysaccharide), as well as impaired liver antimicro...
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| Format: | Article |
| Language: | English |
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Kazimierz Wielki University
2019-11-01
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| Series: | Journal of Education, Health and Sport |
| Subjects: | |
| Online Access: | https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/29148 |
| _version_ | 1818363142065881088 |
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| author | A. V. Bocharov A. P. Levitsky N. S. Badiuk W. Zukow |
| author_facet | A. V. Bocharov A. P. Levitsky N. S. Badiuk W. Zukow |
| author_sort | A. V. Bocharov |
| collection | DOAJ |
| description | <p>Nonspecific colitis (inflammation of the colon mucosa) is a common gastroenterological disease. The causative factors of this disease are intestinal dysbiosis, which leads to an increase in blood concentration of intestinal endotoxin (lipopolysaccharide), as well as impaired liver antimicrobial function.</p><p>The purpose of this study was to determine the possibility of preventing colitis, which develops as a result of a combination of dysbiosis and hepatitis, with the help of biotrit, which has an antidysbiotic and hepatoprotective effect.</p><p>The experiments were conducted on 24 white rats of the Wistar line (males, 1 month old), divided into 3 equal groups: 1 - control (normal); 2 - dysbiosis + hepatitis without treatment; 3 - dysbiosis + hepatitis + drug "Biotrit".</p><p>Dysbiosis was caused by the antibiotic lincomycin, which was given to rats with drinking water at a dose of 60 mg / kg for the first 5 days. Toxic hepatitis was reproduced in rats using hydrazine hydrochloride.</p><p>Studies have shown that the phytopreparation Biotrit has a mucosoprotective effect in experimental nonspecific colitis due to both antidysbiotic and antioxidant effects.</p> |
| first_indexed | 2024-12-13T21:43:46Z |
| format | Article |
| id | doaj.art-0869c3fd21344aca9ad1d2c9701c16cb |
| institution | Directory Open Access Journal |
| issn | 2391-8306 |
| language | English |
| last_indexed | 2024-12-13T21:43:46Z |
| publishDate | 2019-11-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj.art-0869c3fd21344aca9ad1d2c9701c16cb2022-12-21T23:30:27ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062019-11-0191138138510.12775/JEHS.2019.09.11.03523925Experimental treatment of dysbiosis in colitis with hepatitisA. V. Bocharov0A. P. Levitsky1N. S. Badiuk2W. Zukow3Bukovinian State Medical UniversityState Etablishment «The Institute of Stomatology and Maxillo-Facial Surgery of the National Academy of Medical Science of Ukraine»Ukrainian Scientific Research Institute of Medicine for TransportNicolaus Copernicus University<p>Nonspecific colitis (inflammation of the colon mucosa) is a common gastroenterological disease. The causative factors of this disease are intestinal dysbiosis, which leads to an increase in blood concentration of intestinal endotoxin (lipopolysaccharide), as well as impaired liver antimicrobial function.</p><p>The purpose of this study was to determine the possibility of preventing colitis, which develops as a result of a combination of dysbiosis and hepatitis, with the help of biotrit, which has an antidysbiotic and hepatoprotective effect.</p><p>The experiments were conducted on 24 white rats of the Wistar line (males, 1 month old), divided into 3 equal groups: 1 - control (normal); 2 - dysbiosis + hepatitis without treatment; 3 - dysbiosis + hepatitis + drug "Biotrit".</p><p>Dysbiosis was caused by the antibiotic lincomycin, which was given to rats with drinking water at a dose of 60 mg / kg for the first 5 days. Toxic hepatitis was reproduced in rats using hydrazine hydrochloride.</p><p>Studies have shown that the phytopreparation Biotrit has a mucosoprotective effect in experimental nonspecific colitis due to both antidysbiotic and antioxidant effects.</p>https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/29148colitishepatitisdysbiosisherbal remedies |
| spellingShingle | A. V. Bocharov A. P. Levitsky N. S. Badiuk W. Zukow Experimental treatment of dysbiosis in colitis with hepatitis Journal of Education, Health and Sport colitis hepatitis dysbiosis herbal remedies |
| title | Experimental treatment of dysbiosis in colitis with hepatitis |
| title_full | Experimental treatment of dysbiosis in colitis with hepatitis |
| title_fullStr | Experimental treatment of dysbiosis in colitis with hepatitis |
| title_full_unstemmed | Experimental treatment of dysbiosis in colitis with hepatitis |
| title_short | Experimental treatment of dysbiosis in colitis with hepatitis |
| title_sort | experimental treatment of dysbiosis in colitis with hepatitis |
| topic | colitis hepatitis dysbiosis herbal remedies |
| url | https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/29148 |
| work_keys_str_mv | AT avbocharov experimentaltreatmentofdysbiosisincolitiswithhepatitis AT aplevitsky experimentaltreatmentofdysbiosisincolitiswithhepatitis AT nsbadiuk experimentaltreatmentofdysbiosisincolitiswithhepatitis AT wzukow experimentaltreatmentofdysbiosisincolitiswithhepatitis |