Thalamic local field potentials recorded using the deep brain stimulation pulse generator
Background: Essential tremor (ET) is one of the most common movement disorders, and continuous deep brain stimulation (DBS) is an established treatment for medication-refractory cases. However, the need for increasing stimulation intensities, with unpleasant side effects, and DBS tolerance over time...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Clinical Neurophysiology Practice |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2467981X22000129 |
| _version_ | 1811197649680859136 |
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| author | A.W.G Buijink D.A. Piña-Fuentes M.J. Stam M. Bot P.R. Schuurman P. van den Munckhof A.F. van Rootselaar R.M.A. de Bie M. Beudel |
| author_facet | A.W.G Buijink D.A. Piña-Fuentes M.J. Stam M. Bot P.R. Schuurman P. van den Munckhof A.F. van Rootselaar R.M.A. de Bie M. Beudel |
| author_sort | A.W.G Buijink |
| collection | DOAJ |
| description | Background: Essential tremor (ET) is one of the most common movement disorders, and continuous deep brain stimulation (DBS) is an established treatment for medication-refractory cases. However, the need for increasing stimulation intensities, with unpleasant side effects, and DBS tolerance over time can be problematic. The advent of novel DBS devices now provides the opportunity to longitudinally record LFPs using the implanted pulse generator, which opens up possibilities to implement adaptive DBS algorithms in a real-life setting. Methods: Here we report a case of thalamic LFP activity recorded using a commercially available sensing-enabled DBS pulse generator (Medtronic Percept PC). Results: In the OFF-stimulation condition, a peak tremor frequency of 3.8 Hz was identified during tremor evoking movements as assessed by video and accelerometers. Activity at the same and supraharmonic frequency was seen in the frequency spectrum of the LFP data from the left vim nucleus during motor tasks. Coherence analysis showed that peripherally recorded tremor was coherent with the LFP signal at the tremor frequency and supraharmonic frequency. Conclusion: This is the first report of recorded tremor-related thalamic activity using the electrodes and pulse generator of an implanted DBS system. Larger studies are needed to evaluate the clinical potential of these fully implantable systems, and ultimately pulse generators with sensing-coupled algorithms driving stimulation, to really close the loop. |
| first_indexed | 2024-04-12T01:17:14Z |
| format | Article |
| id | doaj.art-086a4ee0bb1f4c19964ad0d3b0d57e73 |
| institution | Directory Open Access Journal |
| issn | 2467-981X |
| language | English |
| last_indexed | 2024-04-12T01:17:14Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Neurophysiology Practice |
| spelling | doaj.art-086a4ee0bb1f4c19964ad0d3b0d57e732022-12-22T03:53:54ZengElsevierClinical Neurophysiology Practice2467-981X2022-01-017103106Thalamic local field potentials recorded using the deep brain stimulation pulse generatorA.W.G Buijink0D.A. Piña-Fuentes1M.J. Stam2M. Bot3P.R. Schuurman4P. van den Munckhof5A.F. van Rootselaar6R.M.A. de Bie7M. Beudel8Department of Neurology, Amsterdam University Medical Centers, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, The Netherlands; Corresponding author at: Department of Neurology, Amsterdam University Medical Centers, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands.Department of Neurology, Amsterdam University Medical Centers, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, The NetherlandsDepartment of Neurology, Amsterdam University Medical Centers, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, The NetherlandsDepartment of Neurosurgery, Amsterdam University Medical Centers, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, The NetherlandsDepartment of Neurosurgery, Amsterdam University Medical Centers, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, The NetherlandsDepartment of Neurosurgery, Amsterdam University Medical Centers, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, The NetherlandsDepartment of Neurology, Amsterdam University Medical Centers, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, The NetherlandsDepartment of Neurology, Amsterdam University Medical Centers, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, The NetherlandsDepartment of Neurology, Amsterdam University Medical Centers, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, The NetherlandsBackground: Essential tremor (ET) is one of the most common movement disorders, and continuous deep brain stimulation (DBS) is an established treatment for medication-refractory cases. However, the need for increasing stimulation intensities, with unpleasant side effects, and DBS tolerance over time can be problematic. The advent of novel DBS devices now provides the opportunity to longitudinally record LFPs using the implanted pulse generator, which opens up possibilities to implement adaptive DBS algorithms in a real-life setting. Methods: Here we report a case of thalamic LFP activity recorded using a commercially available sensing-enabled DBS pulse generator (Medtronic Percept PC). Results: In the OFF-stimulation condition, a peak tremor frequency of 3.8 Hz was identified during tremor evoking movements as assessed by video and accelerometers. Activity at the same and supraharmonic frequency was seen in the frequency spectrum of the LFP data from the left vim nucleus during motor tasks. Coherence analysis showed that peripherally recorded tremor was coherent with the LFP signal at the tremor frequency and supraharmonic frequency. Conclusion: This is the first report of recorded tremor-related thalamic activity using the electrodes and pulse generator of an implanted DBS system. Larger studies are needed to evaluate the clinical potential of these fully implantable systems, and ultimately pulse generators with sensing-coupled algorithms driving stimulation, to really close the loop.http://www.sciencedirect.com/science/article/pii/S2467981X22000129TremorAdaptiveClosed-loopDeep brain stimulationEssential tremor |
| spellingShingle | A.W.G Buijink D.A. Piña-Fuentes M.J. Stam M. Bot P.R. Schuurman P. van den Munckhof A.F. van Rootselaar R.M.A. de Bie M. Beudel Thalamic local field potentials recorded using the deep brain stimulation pulse generator Clinical Neurophysiology Practice Tremor Adaptive Closed-loop Deep brain stimulation Essential tremor |
| title | Thalamic local field potentials recorded using the deep brain stimulation pulse generator |
| title_full | Thalamic local field potentials recorded using the deep brain stimulation pulse generator |
| title_fullStr | Thalamic local field potentials recorded using the deep brain stimulation pulse generator |
| title_full_unstemmed | Thalamic local field potentials recorded using the deep brain stimulation pulse generator |
| title_short | Thalamic local field potentials recorded using the deep brain stimulation pulse generator |
| title_sort | thalamic local field potentials recorded using the deep brain stimulation pulse generator |
| topic | Tremor Adaptive Closed-loop Deep brain stimulation Essential tremor |
| url | http://www.sciencedirect.com/science/article/pii/S2467981X22000129 |
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