Mucoadhesive Delivery System: A Smart Way to Improve Bioavailability of Nutraceuticals
The conventional oral administration of many nutraceuticals exhibits poor oral bioavailability due to the harsh gastric conditions and first-pass metabolism. Oral mucosa has been recognized as a potential site for the delivery of therapeutic compounds. The mucoadhesive formulation can adhere to the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/10/6/1362 |
| _version_ | 1797530369445068800 |
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| author | Parthasarathi Subramanian |
| author_facet | Parthasarathi Subramanian |
| author_sort | Parthasarathi Subramanian |
| collection | DOAJ |
| description | The conventional oral administration of many nutraceuticals exhibits poor oral bioavailability due to the harsh gastric conditions and first-pass metabolism. Oral mucosa has been recognized as a potential site for the delivery of therapeutic compounds. The mucoadhesive formulation can adhere to the mucosal membrane through various interaction mechanisms and enhance the retention and permeability of bioactive compounds. Absorption of bioactive compounds from the mucosa can improve bioavailability, as this route bypasses the hepatic first-pass metabolism and transit through the gastrointestinal tract. The mucosal administration is convenient, simple to access, and reported for increasing the bioactive concentration in plasma. Many mucoadhesive polymers, emulsifiers, thickeners used for the pharmaceutical formulation are accepted in the food sector. Introducing mucoadhesive formulations specific to the nutraceutical sector will be a game-changer as we are still looking for different ways to improve the bioavailability of many bioactive compounds. This article describes the overview of buccal mucosa, the concept of mucoadhesion and related theories, and different techniques of mucoadhesive formulations. Finally, the classification of mucoadhesive polymers and the mucoadhesive systems designed for the effective delivery of bioactive compounds are presented. |
| first_indexed | 2024-03-10T10:28:56Z |
| format | Article |
| id | doaj.art-086a63060cba4ed18ce94a5b031e8056 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-10T10:28:56Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-086a63060cba4ed18ce94a5b031e80562023-11-21T23:48:13ZengMDPI AGFoods2304-81582021-06-01106136210.3390/foods10061362Mucoadhesive Delivery System: A Smart Way to Improve Bioavailability of NutraceuticalsParthasarathi Subramanian0Riddet Institute, Massey University, Private Bag 11222, Palmerston North 4442, New ZealandThe conventional oral administration of many nutraceuticals exhibits poor oral bioavailability due to the harsh gastric conditions and first-pass metabolism. Oral mucosa has been recognized as a potential site for the delivery of therapeutic compounds. The mucoadhesive formulation can adhere to the mucosal membrane through various interaction mechanisms and enhance the retention and permeability of bioactive compounds. Absorption of bioactive compounds from the mucosa can improve bioavailability, as this route bypasses the hepatic first-pass metabolism and transit through the gastrointestinal tract. The mucosal administration is convenient, simple to access, and reported for increasing the bioactive concentration in plasma. Many mucoadhesive polymers, emulsifiers, thickeners used for the pharmaceutical formulation are accepted in the food sector. Introducing mucoadhesive formulations specific to the nutraceutical sector will be a game-changer as we are still looking for different ways to improve the bioavailability of many bioactive compounds. This article describes the overview of buccal mucosa, the concept of mucoadhesion and related theories, and different techniques of mucoadhesive formulations. Finally, the classification of mucoadhesive polymers and the mucoadhesive systems designed for the effective delivery of bioactive compounds are presented.https://www.mdpi.com/2304-8158/10/6/1362bioavailabilitymucosal delivery systemnutraceuticalsbioactive compoundsfilmswafers |
| spellingShingle | Parthasarathi Subramanian Mucoadhesive Delivery System: A Smart Way to Improve Bioavailability of Nutraceuticals Foods bioavailability mucosal delivery system nutraceuticals bioactive compounds films wafers |
| title | Mucoadhesive Delivery System: A Smart Way to Improve Bioavailability of Nutraceuticals |
| title_full | Mucoadhesive Delivery System: A Smart Way to Improve Bioavailability of Nutraceuticals |
| title_fullStr | Mucoadhesive Delivery System: A Smart Way to Improve Bioavailability of Nutraceuticals |
| title_full_unstemmed | Mucoadhesive Delivery System: A Smart Way to Improve Bioavailability of Nutraceuticals |
| title_short | Mucoadhesive Delivery System: A Smart Way to Improve Bioavailability of Nutraceuticals |
| title_sort | mucoadhesive delivery system a smart way to improve bioavailability of nutraceuticals |
| topic | bioavailability mucosal delivery system nutraceuticals bioactive compounds films wafers |
| url | https://www.mdpi.com/2304-8158/10/6/1362 |
| work_keys_str_mv | AT parthasarathisubramanian mucoadhesivedeliverysystemasmartwaytoimprovebioavailabilityofnutraceuticals |