Biological Properties of a Citral-Enriched Fraction of <i>Citrus limon</i> Essential Oil
Lemon essential oil (LEO) is a well-known flavoring agent with versatile biological activities. In the present study, we have isolated and characterized four citral-enriched fractions of winter LEO. We reported that in murine and human macrophages the pre-treatment with a mix of these fractions (Cfr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/9/9/1290 |
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| author | Marzia Pucci Stefania Raimondo Chiara Zichittella Vincenza Tinnirello Valeria Corleone Gioacchino Aiello Marta Moschetti Alice Conigliaro Simona Fontana Riccardo Alessandro |
| author_facet | Marzia Pucci Stefania Raimondo Chiara Zichittella Vincenza Tinnirello Valeria Corleone Gioacchino Aiello Marta Moschetti Alice Conigliaro Simona Fontana Riccardo Alessandro |
| author_sort | Marzia Pucci |
| collection | DOAJ |
| description | Lemon essential oil (LEO) is a well-known flavoring agent with versatile biological activities. In the present study, we have isolated and characterized four citral-enriched fractions of winter LEO. We reported that in murine and human macrophages the pre-treatment with a mix of these fractions (Cfr-LEO) reduces the expression of the pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 induced by LPS. In addition, Cfr-LEO counteracts LPS-induced oxidative stress, as shown by the increase in the GSH/GSSG ratio in comparison to cells treated with LPS alone. Overall, the results reported here encourage the application of EO fractions, enriched in citral, in the nutraceutical industry, not only for its organoleptic properties but also for its protective action against inflammation and oxidative stress. |
| first_indexed | 2024-03-10T16:21:09Z |
| format | Article |
| id | doaj.art-086addd377f3490c8e66504c42332f23 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-10T16:21:09Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-086addd377f3490c8e66504c42332f232023-11-20T13:39:21ZengMDPI AGFoods2304-81582020-09-0199129010.3390/foods9091290Biological Properties of a Citral-Enriched Fraction of <i>Citrus limon</i> Essential OilMarzia Pucci0Stefania Raimondo1Chiara Zichittella2Vincenza Tinnirello3Valeria Corleone4Gioacchino Aiello5Marta Moschetti6Alice Conigliaro7Simona Fontana8Riccardo Alessandro9Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D), Section of Biology and Genetics, University of Palermo, 90133 Palermo, ItalyDepartment of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D), Section of Biology and Genetics, University of Palermo, 90133 Palermo, ItalyDepartment of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D), Section of Biology and Genetics, University of Palermo, 90133 Palermo, ItalyAgrumaria Corleone s.p.a., Via S. Corleone, 12-Zona Ind. Brancaccio, 90124 Palermo, ItalyAgrumaria Corleone s.p.a., Via S. Corleone, 12-Zona Ind. Brancaccio, 90124 Palermo, ItalyAgrumaria Corleone s.p.a., Via S. Corleone, 12-Zona Ind. Brancaccio, 90124 Palermo, ItalyDepartment of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D), Section of Biology and Genetics, University of Palermo, 90133 Palermo, ItalyDepartment of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D), Section of Biology and Genetics, University of Palermo, 90133 Palermo, ItalyDepartment of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D), Section of Biology and Genetics, University of Palermo, 90133 Palermo, ItalyDepartment of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D), Section of Biology and Genetics, University of Palermo, 90133 Palermo, ItalyLemon essential oil (LEO) is a well-known flavoring agent with versatile biological activities. In the present study, we have isolated and characterized four citral-enriched fractions of winter LEO. We reported that in murine and human macrophages the pre-treatment with a mix of these fractions (Cfr-LEO) reduces the expression of the pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 induced by LPS. In addition, Cfr-LEO counteracts LPS-induced oxidative stress, as shown by the increase in the GSH/GSSG ratio in comparison to cells treated with LPS alone. Overall, the results reported here encourage the application of EO fractions, enriched in citral, in the nutraceutical industry, not only for its organoleptic properties but also for its protective action against inflammation and oxidative stress.https://www.mdpi.com/2304-8158/9/9/1290<i>Citrus limon</i> (L.) Osbeckessential oilcitralnutraceuticalsinflammationoxidative stress |
| spellingShingle | Marzia Pucci Stefania Raimondo Chiara Zichittella Vincenza Tinnirello Valeria Corleone Gioacchino Aiello Marta Moschetti Alice Conigliaro Simona Fontana Riccardo Alessandro Biological Properties of a Citral-Enriched Fraction of <i>Citrus limon</i> Essential Oil Foods <i>Citrus limon</i> (L.) Osbeck essential oil citral nutraceuticals inflammation oxidative stress |
| title | Biological Properties of a Citral-Enriched Fraction of <i>Citrus limon</i> Essential Oil |
| title_full | Biological Properties of a Citral-Enriched Fraction of <i>Citrus limon</i> Essential Oil |
| title_fullStr | Biological Properties of a Citral-Enriched Fraction of <i>Citrus limon</i> Essential Oil |
| title_full_unstemmed | Biological Properties of a Citral-Enriched Fraction of <i>Citrus limon</i> Essential Oil |
| title_short | Biological Properties of a Citral-Enriched Fraction of <i>Citrus limon</i> Essential Oil |
| title_sort | biological properties of a citral enriched fraction of i citrus limon i essential oil |
| topic | <i>Citrus limon</i> (L.) Osbeck essential oil citral nutraceuticals inflammation oxidative stress |
| url | https://www.mdpi.com/2304-8158/9/9/1290 |
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