The Relationship between Atherosclerosis and Gut Microbiome in Patients with Obstructive Sleep Apnoea
Background: Obstructive sleep apnoea (OSA) and gut dysbiosis are known risk factors for atherosclerosis. However, only very few studies have been focused on the relationship between OSA, atherosclerosis, and the intestinal microbiome, all in animal models. Methods: Twenty-two patients with OSA, 16 w...
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/12/22/11484 |
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| author | Helga Szabo Marton Piroska Anita Hernyes Luca Zoldi Janos Juhasz Balazs Ligeti Nora Makra Dora Szabo Andras Bikov Laszlo Kunos Adam Domonkos Tarnoki David Laszlo Tarnoki |
| author_facet | Helga Szabo Marton Piroska Anita Hernyes Luca Zoldi Janos Juhasz Balazs Ligeti Nora Makra Dora Szabo Andras Bikov Laszlo Kunos Adam Domonkos Tarnoki David Laszlo Tarnoki |
| author_sort | Helga Szabo |
| collection | DOAJ |
| description | Background: Obstructive sleep apnoea (OSA) and gut dysbiosis are known risk factors for atherosclerosis. However, only very few studies have been focused on the relationship between OSA, atherosclerosis, and the intestinal microbiome, all in animal models. Methods: Twenty-two patients with OSA, 16 with and 6 without carotid atherosclerosis were involved in the study. After a diagnostic sleep examination, the intima media thickness (IMT) was measured and plaques were found using carotid ultrasound. Blood was also drawn for metabolic profile, and a stool sample was provided for 16S ribosomal RNA microbiome investigation. Results: An increased maximal common carotid artery (CCA) IMT was significantly associated with decreased phylum-level diversity. The level of <i>Peptostreptococcaceae</i> was significantly lower in atherosclerotic subjects. Some other candidate microbes appeared in the two groups at the genus level as well: <i>Bilophila</i>, <i>Romboutsia</i>, <i>Slackia</i>, and <i>Veillonella</i> in the non-atherosclerotic group; and <i>Escherichia-Shigella</i>, <i>Prevotella</i>, and <i>Ruminococcaceae</i> in the atherosclerotic group. Conclusions: This is the first pilot research to analyze the association between the gut microbiome and atherosclerosis in adult patients with OSA with and without carotid atherosclerosis. Dysbiosis and individual bacteria may contribute to the development of carotid atherosclerosis in patients with OSA. Further investigations are necessary to reveal a more precise background in a larger sample. |
| first_indexed | 2024-03-09T18:29:56Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-09T18:29:56Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-086afcd128154e98a720cd252b65cd382023-11-24T07:36:03ZengMDPI AGApplied Sciences2076-34172022-11-0112221148410.3390/app122211484The Relationship between Atherosclerosis and Gut Microbiome in Patients with Obstructive Sleep ApnoeaHelga Szabo0Marton Piroska1Anita Hernyes2Luca Zoldi3Janos Juhasz4Balazs Ligeti5Nora Makra6Dora Szabo7Andras Bikov8Laszlo Kunos9Adam Domonkos Tarnoki10David Laszlo Tarnoki11Medical Imaging Centre, Semmelweis University, 1082 Budapest, HungaryMedical Imaging Centre, Semmelweis University, 1082 Budapest, HungaryMedical Imaging Centre, Semmelweis University, 1082 Budapest, HungaryMedical Imaging Centre, Semmelweis University, 1082 Budapest, HungaryInstitute of Medical Microbiology, Semmelweis University, 1085 Budapest, HungaryFaculty of Information Technology and Bionics, Pazmany Peter Catholic University, 1085 Budapest, HungaryInstitute of Medical Microbiology, Semmelweis University, 1085 Budapest, HungaryInstitute of Medical Microbiology, Semmelweis University, 1085 Budapest, HungaryNorth West Lung Centre, Wythenshawe Hospital, Manchester University Foundation Trust, Manchester M23 9LT, UKInstitute of Pulmonology, 2045 Torokbalint, HungaryMedical Imaging Centre, Semmelweis University, 1082 Budapest, HungaryMedical Imaging Centre, Semmelweis University, 1082 Budapest, HungaryBackground: Obstructive sleep apnoea (OSA) and gut dysbiosis are known risk factors for atherosclerosis. However, only very few studies have been focused on the relationship between OSA, atherosclerosis, and the intestinal microbiome, all in animal models. Methods: Twenty-two patients with OSA, 16 with and 6 without carotid atherosclerosis were involved in the study. After a diagnostic sleep examination, the intima media thickness (IMT) was measured and plaques were found using carotid ultrasound. Blood was also drawn for metabolic profile, and a stool sample was provided for 16S ribosomal RNA microbiome investigation. Results: An increased maximal common carotid artery (CCA) IMT was significantly associated with decreased phylum-level diversity. The level of <i>Peptostreptococcaceae</i> was significantly lower in atherosclerotic subjects. Some other candidate microbes appeared in the two groups at the genus level as well: <i>Bilophila</i>, <i>Romboutsia</i>, <i>Slackia</i>, and <i>Veillonella</i> in the non-atherosclerotic group; and <i>Escherichia-Shigella</i>, <i>Prevotella</i>, and <i>Ruminococcaceae</i> in the atherosclerotic group. Conclusions: This is the first pilot research to analyze the association between the gut microbiome and atherosclerosis in adult patients with OSA with and without carotid atherosclerosis. Dysbiosis and individual bacteria may contribute to the development of carotid atherosclerosis in patients with OSA. Further investigations are necessary to reveal a more precise background in a larger sample.https://www.mdpi.com/2076-3417/12/22/11484gut microbiomealpha diversityintima-media thicknesscarotid atherosclerosisultrasoundsleep apnoea |
| spellingShingle | Helga Szabo Marton Piroska Anita Hernyes Luca Zoldi Janos Juhasz Balazs Ligeti Nora Makra Dora Szabo Andras Bikov Laszlo Kunos Adam Domonkos Tarnoki David Laszlo Tarnoki The Relationship between Atherosclerosis and Gut Microbiome in Patients with Obstructive Sleep Apnoea Applied Sciences gut microbiome alpha diversity intima-media thickness carotid atherosclerosis ultrasound sleep apnoea |
| title | The Relationship between Atherosclerosis and Gut Microbiome in Patients with Obstructive Sleep Apnoea |
| title_full | The Relationship between Atherosclerosis and Gut Microbiome in Patients with Obstructive Sleep Apnoea |
| title_fullStr | The Relationship between Atherosclerosis and Gut Microbiome in Patients with Obstructive Sleep Apnoea |
| title_full_unstemmed | The Relationship between Atherosclerosis and Gut Microbiome in Patients with Obstructive Sleep Apnoea |
| title_short | The Relationship between Atherosclerosis and Gut Microbiome in Patients with Obstructive Sleep Apnoea |
| title_sort | relationship between atherosclerosis and gut microbiome in patients with obstructive sleep apnoea |
| topic | gut microbiome alpha diversity intima-media thickness carotid atherosclerosis ultrasound sleep apnoea |
| url | https://www.mdpi.com/2076-3417/12/22/11484 |
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