Phenylboronic acid conjugated multifunctional nanogels with 131I-labeling for targeted SPECT imaging and radiotherapy of breast adenocarcinoma
We report a new 131I-labeling functional platform for targeted single-photon emission computed tomography (SPECT) imaging and radiotherapy of breast adenocarcinoma. In this study, polyethyleneimine (PEI) based nanogels (P.NH2 NGs) were prepared by water/oil polymerization, modified with targeted age...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.973141/full |
| _version_ | 1828783801048760320 |
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| author | Lingdan Kong Jingyi Zhu Hongxing Su Lingzhou Zhao Yi Lu Meilin Zhu Wenjie Sun |
| author_facet | Lingdan Kong Jingyi Zhu Hongxing Su Lingzhou Zhao Yi Lu Meilin Zhu Wenjie Sun |
| author_sort | Lingdan Kong |
| collection | DOAJ |
| description | We report a new 131I-labeling functional platform for targeted single-photon emission computed tomography (SPECT) imaging and radiotherapy of breast adenocarcinoma. In this study, polyethyleneimine (PEI) based nanogels (P.NH2 NGs) were prepared by water/oil polymerization, modified with targeted agent phenylboronic acid (PBA), and labeled with radionuclide 131I. The NGs without 131I-labeling own a spherical structure, uniform size distribution, and good cell viability. After 131I-labeling, the obtained 131I-PBA-PHP NGs displayed much higher cellular uptake than the non-targeted NGs due to the good softness and fluidity of NGs and the PBA targeting. The in vivo results demonstrated that 131I-PBA-PHP NGs could specifically target breast cancer cells and efficiently aggregate into xenograft breast adenocarcinoma for tumor SPECT imaging and specific radiotherapy. The developed 131I-labeling NGs may be used as a promising platform for efficient radioactive theranostic nanoplatform of tumor. |
| first_indexed | 2024-12-11T23:18:51Z |
| format | Article |
| id | doaj.art-086b93e96f8b47f6950558ecc9b76412 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-11T23:18:51Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-086b93e96f8b47f6950558ecc9b764122022-12-22T00:46:23ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-07-011010.3389/fbioe.2022.973141973141Phenylboronic acid conjugated multifunctional nanogels with 131I-labeling for targeted SPECT imaging and radiotherapy of breast adenocarcinomaLingdan Kong0Jingyi Zhu1Hongxing Su2Lingzhou Zhao3Yi Lu4Meilin Zhu5Wenjie Sun6School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, ChinaSchool of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, ChinaDepartment of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaInstitute of Biotechnology, RWTH Aachen University, Aachen, GermanySchool of Basic Medical Sciences, Ningxia Medical University, Yinchuan, ChinaSchool of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, ChinaWe report a new 131I-labeling functional platform for targeted single-photon emission computed tomography (SPECT) imaging and radiotherapy of breast adenocarcinoma. In this study, polyethyleneimine (PEI) based nanogels (P.NH2 NGs) were prepared by water/oil polymerization, modified with targeted agent phenylboronic acid (PBA), and labeled with radionuclide 131I. The NGs without 131I-labeling own a spherical structure, uniform size distribution, and good cell viability. After 131I-labeling, the obtained 131I-PBA-PHP NGs displayed much higher cellular uptake than the non-targeted NGs due to the good softness and fluidity of NGs and the PBA targeting. The in vivo results demonstrated that 131I-PBA-PHP NGs could specifically target breast cancer cells and efficiently aggregate into xenograft breast adenocarcinoma for tumor SPECT imaging and specific radiotherapy. The developed 131I-labeling NGs may be used as a promising platform for efficient radioactive theranostic nanoplatform of tumor.https://www.frontiersin.org/articles/10.3389/fbioe.2022.973141/fullphenylboronic acidnanogelSPECT imagingradiotherapybreast adenocarcinoma |
| spellingShingle | Lingdan Kong Jingyi Zhu Hongxing Su Lingzhou Zhao Yi Lu Meilin Zhu Wenjie Sun Phenylboronic acid conjugated multifunctional nanogels with 131I-labeling for targeted SPECT imaging and radiotherapy of breast adenocarcinoma Frontiers in Bioengineering and Biotechnology phenylboronic acid nanogel SPECT imaging radiotherapy breast adenocarcinoma |
| title | Phenylboronic acid conjugated multifunctional nanogels with 131I-labeling for targeted SPECT imaging and radiotherapy of breast adenocarcinoma |
| title_full | Phenylboronic acid conjugated multifunctional nanogels with 131I-labeling for targeted SPECT imaging and radiotherapy of breast adenocarcinoma |
| title_fullStr | Phenylboronic acid conjugated multifunctional nanogels with 131I-labeling for targeted SPECT imaging and radiotherapy of breast adenocarcinoma |
| title_full_unstemmed | Phenylboronic acid conjugated multifunctional nanogels with 131I-labeling for targeted SPECT imaging and radiotherapy of breast adenocarcinoma |
| title_short | Phenylboronic acid conjugated multifunctional nanogels with 131I-labeling for targeted SPECT imaging and radiotherapy of breast adenocarcinoma |
| title_sort | phenylboronic acid conjugated multifunctional nanogels with 131i labeling for targeted spect imaging and radiotherapy of breast adenocarcinoma |
| topic | phenylboronic acid nanogel SPECT imaging radiotherapy breast adenocarcinoma |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.973141/full |
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