The Poly I:C maternal immune stimulation model shows unique patterns of brain metabolism, morphometry, and plasticity in female rats

The Poly I:C maternal immune stimulation model shows unique patterns of brain metabolism, morphometry, and plasticity in female rats

Introduction: Prenatal infections are associated with an increased risk of the onset of schizophrenia. Rodent models of maternal immune stimulation (MIS) have been extensively used in preclinical studies. However, many of these studies only include males, omitting pathophysiological features unique...

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Bibliographic Details
Main Authors: Marta Casquero-Veiga, Nicolás Lamanna-Rama, Diego Romero-Miguel, Henar Rojas-Marquez, Julia Alcaide, Marc Beltran, Juan Nacher, Manuel Desco, Maria Luisa Soto-Montenegro
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
mental disorders
schizophrenia
maternal immune stimulation
Poly I:C
sex differences
FDG-PET
Online Access:https://www.frontiersin.org/articles/10.3389/fnbeh.2022.1022622/full

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