Blast Exposure Dysregulates Nighttime Melatonin Synthesis and Signaling in the Pineal Gland: A Potential Mechanism of Blast-Induced Sleep Disruptions

Blast Exposure Dysregulates Nighttime Melatonin Synthesis and Signaling in the Pineal Gland: A Potential Mechanism of Blast-Induced Sleep Disruptions

Blast-induced traumatic brain injury (bTBI) frequently results in sleep-wake disturbances. However, limited studies have investigated the molecular signaling mechanisms underlying these sleep disturbances, and potentially efficacious therapies are lacking. We investigated the levels of melatonin and...

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Bibliographic Details
Main Authors: Manoj Govindarajulu, Mital Y. Patel, Donna M. Wilder, Joseph B. Long, Peethambaran Arun
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Brain Sciences
Subjects:
blast injury
circadian rhythm
melatonin
pineal gland
gene expression
Online Access:https://www.mdpi.com/2076-3425/12/10/1340

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