Shared rhythmic subcortical GABAergic input to the entorhinal cortex and presubiculum
Rhythmic theta frequency (~5–12 Hz) oscillations coordinate neuronal synchrony and higher frequency oscillations across the cortex. Spatial navigation and context-dependent episodic memories are represented in several interconnected regions including the hippocampal and entorhinal cortices, but the...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2018-04-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/34395 |
| _version_ | 1811253163348459520 |
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| author | Tim James Viney Minas Salib Abhilasha Joshi Gunes Unal Naomi Berry Peter Somogyi |
| author_facet | Tim James Viney Minas Salib Abhilasha Joshi Gunes Unal Naomi Berry Peter Somogyi |
| author_sort | Tim James Viney |
| collection | DOAJ |
| description | Rhythmic theta frequency (~5–12 Hz) oscillations coordinate neuronal synchrony and higher frequency oscillations across the cortex. Spatial navigation and context-dependent episodic memories are represented in several interconnected regions including the hippocampal and entorhinal cortices, but the cellular mechanisms for their dynamic coupling remain to be defined. Using monosynaptically-restricted retrograde viral tracing in mice, we identified a subcortical GABAergic input from the medial septum that terminated in the entorhinal cortex, with collaterals innervating the dorsal presubiculum. Extracellularly recording and labeling GABAergic entorhinal-projecting neurons in awake behaving mice show that these subcortical neurons, named orchid cells, fire in long rhythmic bursts during immobility and locomotion. Orchid cells discharge near the peak of hippocampal and entorhinal theta oscillations, couple to entorhinal gamma oscillations, and target subpopulations of extra-hippocampal GABAergic interneurons. Thus, orchid cells are a specialized source of rhythmic subcortical GABAergic modulation of ‘upstream’ and ‘downstream’ cortico-cortical circuits involved in mnemonic functions. |
| first_indexed | 2024-04-12T16:45:45Z |
| format | Article |
| id | doaj.art-086e743139ce43fba0c7a8dcde7f0592 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T16:45:45Z |
| publishDate | 2018-04-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-086e743139ce43fba0c7a8dcde7f05922022-12-22T03:24:34ZengeLife Sciences Publications LtdeLife2050-084X2018-04-01710.7554/eLife.34395Shared rhythmic subcortical GABAergic input to the entorhinal cortex and presubiculumTim James Viney0https://orcid.org/0000-0001-6444-1188Minas Salib1https://orcid.org/0000-0001-9938-7978Abhilasha Joshi2https://orcid.org/0000-0002-0511-3747Gunes Unal3https://orcid.org/0000-0003-3013-0271Naomi Berry4Peter Somogyi5Department of Pharmacology, University of Oxford, Oxford, United KingdomDepartment of Pharmacology, University of Oxford, Oxford, United KingdomDepartment of Pharmacology, University of Oxford, Oxford, United KingdomDepartment of Pharmacology, University of Oxford, Oxford, United KingdomDepartment of Pharmacology, University of Oxford, Oxford, United KingdomDepartment of Pharmacology, University of Oxford, Oxford, United KingdomRhythmic theta frequency (~5–12 Hz) oscillations coordinate neuronal synchrony and higher frequency oscillations across the cortex. Spatial navigation and context-dependent episodic memories are represented in several interconnected regions including the hippocampal and entorhinal cortices, but the cellular mechanisms for their dynamic coupling remain to be defined. Using monosynaptically-restricted retrograde viral tracing in mice, we identified a subcortical GABAergic input from the medial septum that terminated in the entorhinal cortex, with collaterals innervating the dorsal presubiculum. Extracellularly recording and labeling GABAergic entorhinal-projecting neurons in awake behaving mice show that these subcortical neurons, named orchid cells, fire in long rhythmic bursts during immobility and locomotion. Orchid cells discharge near the peak of hippocampal and entorhinal theta oscillations, couple to entorhinal gamma oscillations, and target subpopulations of extra-hippocampal GABAergic interneurons. Thus, orchid cells are a specialized source of rhythmic subcortical GABAergic modulation of ‘upstream’ and ‘downstream’ cortico-cortical circuits involved in mnemonic functions.https://elifesciences.org/articles/34395medial septumentorhinal cortexGABAergic neuronstheta oscillationsgamma oscillationsinhibition |
| spellingShingle | Tim James Viney Minas Salib Abhilasha Joshi Gunes Unal Naomi Berry Peter Somogyi Shared rhythmic subcortical GABAergic input to the entorhinal cortex and presubiculum eLife medial septum entorhinal cortex GABAergic neurons theta oscillations gamma oscillations inhibition |
| title | Shared rhythmic subcortical GABAergic input to the entorhinal cortex and presubiculum |
| title_full | Shared rhythmic subcortical GABAergic input to the entorhinal cortex and presubiculum |
| title_fullStr | Shared rhythmic subcortical GABAergic input to the entorhinal cortex and presubiculum |
| title_full_unstemmed | Shared rhythmic subcortical GABAergic input to the entorhinal cortex and presubiculum |
| title_short | Shared rhythmic subcortical GABAergic input to the entorhinal cortex and presubiculum |
| title_sort | shared rhythmic subcortical gabaergic input to the entorhinal cortex and presubiculum |
| topic | medial septum entorhinal cortex GABAergic neurons theta oscillations gamma oscillations inhibition |
| url | https://elifesciences.org/articles/34395 |
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