Optimal Target Level of Low-density Lipoprotein Cholesterol for Vascular Function in Statin Naïve Individuals
Abstract We investigated (1) the relationship between low-density lipoprotein cholesterol (LDL-C) and vascular function in patients receiving and those not receiving statin therapy and (2) optimal level of LDL-C for maintenance of vascular function. Flow-mediated vasodilation (FMD) and nitroglycerin...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-09043-1 |
| _version_ | 1818754299385085952 |
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| author | Shogo Matsui Masato Kajikawa Eisuke Hida Tatsuya Maruhashi Yumiko Iwamoto Akimichi Iwamoto Nozomu Oda Shinji Kishimoto Takayuki Hidaka Yasuki Kihara Kazuaki Chayama Chikara Goto Yoshiki Aibara Ayumu Nakashima Farina Binti Mohamad Yusoff Kensuke Noma Yukihito Higashi |
| author_facet | Shogo Matsui Masato Kajikawa Eisuke Hida Tatsuya Maruhashi Yumiko Iwamoto Akimichi Iwamoto Nozomu Oda Shinji Kishimoto Takayuki Hidaka Yasuki Kihara Kazuaki Chayama Chikara Goto Yoshiki Aibara Ayumu Nakashima Farina Binti Mohamad Yusoff Kensuke Noma Yukihito Higashi |
| author_sort | Shogo Matsui |
| collection | DOAJ |
| description | Abstract We investigated (1) the relationship between low-density lipoprotein cholesterol (LDL-C) and vascular function in patients receiving and those not receiving statin therapy and (2) optimal level of LDL-C for maintenance of vascular function. Flow-mediated vasodilation (FMD) and nitroglycerine-induced vasodilation (NID) were inversely correlated with LDL-C in the 957 statin naïve subjects but not in the 392 subjects receiving statin therapy. In statin naïve subjects, non-high LDL-C (≤100 mg/dL) was independently associated with a decrease in adjusted odds ratio of the low tertile of FMD (OR: 0.62, 95% CI: 0.45–0.85; P = 0.003) and NID (OR: 0.69, 95% CI: 0.50–0.96; P = 0.03). Adjusted odds ratio of the low tertile of FMD was significantly lower in the low LDL-C group (≤70 mg/dL) (OR: 0.47, 95% CI, 0.27–0.81; P = 0.006) and in the moderate LDL-C group (70.1–100 mg/dL) (OR: 0.66, 95% CI, 0.48–0.94; P = 0.02) than in the high LDL-C group (>100 mg/dL). There was no significant difference in FMD between the low LDL-C group and moderate LDL-C group. There were significant relationships of FMD and NID with LDL-C levels in statin naïve subjects. In a general population, LDL-C of ≤100 mg/dL may be the optimal target level for maintenance of endothelial function. |
| first_indexed | 2024-12-18T05:21:03Z |
| format | Article |
| id | doaj.art-086ee88cd92448e982a06566e24945f0 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-18T05:21:03Z |
| publishDate | 2017-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-086ee88cd92448e982a06566e24945f02022-12-21T21:19:40ZengNature PortfolioScientific Reports2045-23222017-08-017111010.1038/s41598-017-09043-1Optimal Target Level of Low-density Lipoprotein Cholesterol for Vascular Function in Statin Naïve IndividualsShogo Matsui0Masato Kajikawa1Eisuke Hida2Tatsuya Maruhashi3Yumiko Iwamoto4Akimichi Iwamoto5Nozomu Oda6Shinji Kishimoto7Takayuki Hidaka8Yasuki Kihara9Kazuaki Chayama10Chikara Goto11Yoshiki Aibara12Ayumu Nakashima13Farina Binti Mohamad Yusoff14Kensuke Noma15Yukihito Higashi16Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical SciencesDivision of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University HospitalCenter for Integrated Medical Research, Hiroshima University HospitalDepartment of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical SciencesDepartment of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical SciencesDepartment of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical SciencesDepartment of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical SciencesDepartment of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical SciencesDepartment of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical SciencesDepartment of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical SciencesDepartment of Gastroenterology and Metabolism, Institute of Biomedical and Health Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityHiroshima International UniversityDepartment of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima UniversityDepartment of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima UniversityDepartment of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima UniversityDivision of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University HospitalDivision of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University HospitalAbstract We investigated (1) the relationship between low-density lipoprotein cholesterol (LDL-C) and vascular function in patients receiving and those not receiving statin therapy and (2) optimal level of LDL-C for maintenance of vascular function. Flow-mediated vasodilation (FMD) and nitroglycerine-induced vasodilation (NID) were inversely correlated with LDL-C in the 957 statin naïve subjects but not in the 392 subjects receiving statin therapy. In statin naïve subjects, non-high LDL-C (≤100 mg/dL) was independently associated with a decrease in adjusted odds ratio of the low tertile of FMD (OR: 0.62, 95% CI: 0.45–0.85; P = 0.003) and NID (OR: 0.69, 95% CI: 0.50–0.96; P = 0.03). Adjusted odds ratio of the low tertile of FMD was significantly lower in the low LDL-C group (≤70 mg/dL) (OR: 0.47, 95% CI, 0.27–0.81; P = 0.006) and in the moderate LDL-C group (70.1–100 mg/dL) (OR: 0.66, 95% CI, 0.48–0.94; P = 0.02) than in the high LDL-C group (>100 mg/dL). There was no significant difference in FMD between the low LDL-C group and moderate LDL-C group. There were significant relationships of FMD and NID with LDL-C levels in statin naïve subjects. In a general population, LDL-C of ≤100 mg/dL may be the optimal target level for maintenance of endothelial function.https://doi.org/10.1038/s41598-017-09043-1 |
| spellingShingle | Shogo Matsui Masato Kajikawa Eisuke Hida Tatsuya Maruhashi Yumiko Iwamoto Akimichi Iwamoto Nozomu Oda Shinji Kishimoto Takayuki Hidaka Yasuki Kihara Kazuaki Chayama Chikara Goto Yoshiki Aibara Ayumu Nakashima Farina Binti Mohamad Yusoff Kensuke Noma Yukihito Higashi Optimal Target Level of Low-density Lipoprotein Cholesterol for Vascular Function in Statin Naïve Individuals Scientific Reports |
| title | Optimal Target Level of Low-density Lipoprotein Cholesterol for Vascular Function in Statin Naïve Individuals |
| title_full | Optimal Target Level of Low-density Lipoprotein Cholesterol for Vascular Function in Statin Naïve Individuals |
| title_fullStr | Optimal Target Level of Low-density Lipoprotein Cholesterol for Vascular Function in Statin Naïve Individuals |
| title_full_unstemmed | Optimal Target Level of Low-density Lipoprotein Cholesterol for Vascular Function in Statin Naïve Individuals |
| title_short | Optimal Target Level of Low-density Lipoprotein Cholesterol for Vascular Function in Statin Naïve Individuals |
| title_sort | optimal target level of low density lipoprotein cholesterol for vascular function in statin naive individuals |
| url | https://doi.org/10.1038/s41598-017-09043-1 |
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