Cytogenetic aberrations in adult acute lymphoblastic leukemia—A population‐based study
Abstract Cytogenetic aberrations are recognized as important prognostic factors in adult acute lymphoblastic leukemia (ALL), but studies seldom include elderly patients. From the population‐based Swedish ALL Registry, we identified 728 patients aged 18–95 years, who were diagnosed with ALL 1997–2015...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-11-01
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| Series: | eJHaem |
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| Online Access: | https://doi.org/10.1002/jha2.300 |
| _version_ | 1797740074832494592 |
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| author | Emma Bergfelt Lennmyr Marie Engvall Gisela Barbany Linda Fogelstrand Hanna Rhodin Helene Hallböök |
| author_facet | Emma Bergfelt Lennmyr Marie Engvall Gisela Barbany Linda Fogelstrand Hanna Rhodin Helene Hallböök |
| author_sort | Emma Bergfelt Lennmyr |
| collection | DOAJ |
| description | Abstract Cytogenetic aberrations are recognized as important prognostic factors in adult acute lymphoblastic leukemia (ALL), but studies seldom include elderly patients. From the population‐based Swedish ALL Registry, we identified 728 patients aged 18–95 years, who were diagnosed with ALL 1997–2015 and had cytogenetic information. Registry data were complemented with original cytogenetic reports. BCR‐ABL1 was the most recurrent aberration, with a frequency of 26%, with additional cytogenetic alterations in 64%. KTM2A rearrangement was the second most frequent aberration found in 7%. Low hypodiploidy‐near triploidy and complex karyotype had negative impact, while t(1;19);TCF3‐PBX1 showed positive impact on overall survival. However, after correction for age only complex karyotype remained significant. |
| first_indexed | 2024-03-12T14:07:18Z |
| format | Article |
| id | doaj.art-086fdd4b700f44dfa0ec8d9f82e1c2b5 |
| institution | Directory Open Access Journal |
| issn | 2688-6146 |
| language | English |
| last_indexed | 2024-03-12T14:07:18Z |
| publishDate | 2021-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | eJHaem |
| spelling | doaj.art-086fdd4b700f44dfa0ec8d9f82e1c2b52023-08-21T14:05:23ZengWileyeJHaem2688-61462021-11-012481381710.1002/jha2.300Cytogenetic aberrations in adult acute lymphoblastic leukemia—A population‐based studyEmma Bergfelt Lennmyr0Marie Engvall1Gisela Barbany2Linda Fogelstrand3Hanna Rhodin4Helene Hallböök5Department of Medical Sciences Uppsala University Uppsala SwedenDepartment of Immunology, Genetics and Pathology Uppsala University Uppsala SwedenDepartment of Molecular Medicine and Surgery Karolinska Institute Stockholm SwedenDepartment of Clinical Chemistry Sahlgrenska University Hospital Gothenburg SwedenDepartment of Medical Sciences Uppsala University Uppsala SwedenDepartment of Medical Sciences Uppsala University Uppsala SwedenAbstract Cytogenetic aberrations are recognized as important prognostic factors in adult acute lymphoblastic leukemia (ALL), but studies seldom include elderly patients. From the population‐based Swedish ALL Registry, we identified 728 patients aged 18–95 years, who were diagnosed with ALL 1997–2015 and had cytogenetic information. Registry data were complemented with original cytogenetic reports. BCR‐ABL1 was the most recurrent aberration, with a frequency of 26%, with additional cytogenetic alterations in 64%. KTM2A rearrangement was the second most frequent aberration found in 7%. Low hypodiploidy‐near triploidy and complex karyotype had negative impact, while t(1;19);TCF3‐PBX1 showed positive impact on overall survival. However, after correction for age only complex karyotype remained significant.https://doi.org/10.1002/jha2.300ALLclinical cytogeneticsclinical hematologycytogenetics of leukemia |
| spellingShingle | Emma Bergfelt Lennmyr Marie Engvall Gisela Barbany Linda Fogelstrand Hanna Rhodin Helene Hallböök Cytogenetic aberrations in adult acute lymphoblastic leukemia—A population‐based study eJHaem ALL clinical cytogenetics clinical hematology cytogenetics of leukemia |
| title | Cytogenetic aberrations in adult acute lymphoblastic leukemia—A population‐based study |
| title_full | Cytogenetic aberrations in adult acute lymphoblastic leukemia—A population‐based study |
| title_fullStr | Cytogenetic aberrations in adult acute lymphoblastic leukemia—A population‐based study |
| title_full_unstemmed | Cytogenetic aberrations in adult acute lymphoblastic leukemia—A population‐based study |
| title_short | Cytogenetic aberrations in adult acute lymphoblastic leukemia—A population‐based study |
| title_sort | cytogenetic aberrations in adult acute lymphoblastic leukemia a population based study |
| topic | ALL clinical cytogenetics clinical hematology cytogenetics of leukemia |
| url | https://doi.org/10.1002/jha2.300 |
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