Talc exposure and risk of stomach cancer: Systematic review and meta-analysis of occupational cohort studies
Background/purpose: Talc powder is widely used in various industries, but the carcinogenic effects associated with talc are not well understood. The objective of this study was to estimate the risk of stomach cancer after occupational talc exposure. Methods: We conducted a meta-analysis was performe...
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Format: | Article |
Language: | English |
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Elsevier
2020-04-01
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Series: | Journal of the Formosan Medical Association |
Online Access: | http://www.sciencedirect.com/science/article/pii/S092966461830353X |
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author | Che-Jui Chang Yu-Kang Tu Pau-Chung Chen Hsiao-Yu Yang |
author_facet | Che-Jui Chang Yu-Kang Tu Pau-Chung Chen Hsiao-Yu Yang |
author_sort | Che-Jui Chang |
collection | DOAJ |
description | Background/purpose: Talc powder is widely used in various industries, but the carcinogenic effects associated with talc are not well understood. The objective of this study was to estimate the risk of stomach cancer after occupational talc exposure. Methods: We conducted a meta-analysis was performed to calculate the meta-relative risk (mRR) of stomach cancer. We searched the MEDLINE, EMBASE, CNKI and Wanfang Data databases for publications prior to January 1, 2017 using talc, cancer, and mortality as the search terms. Only cohort studies with occupational talc exposure and stomach cancer statistics were included. Results: All pooled analyses were based on random-effects models. We selected 13 observational studies (12 publications) for the meta-analysis, and heterogeneity was observed among studies. Workers exposed to all forms of talc had a significantly increased mRR of 1.21 (95% CI: 1.03—1.42, p = 0.02) for stomach cancer. Workers exposed to talc not containing asbestiform fibers also had an increased mRR of 1.26 (95% CI: 0.97—1.63, p = 0.09). Conclusion: The available data showed a positive association between occupational talc exposure and risk of stomach cancer. The association between talc not containing asbestiform fibers and risk of stomach cancer was not significant. Further epidemiological studies are required to evaluate the safety of talc. Keywords: Talcum powder, Asbestos, Gastric cancer, Mortality |
first_indexed | 2024-12-22T22:46:22Z |
format | Article |
id | doaj.art-08729b3abce94a509155e6a16a07e647 |
institution | Directory Open Access Journal |
issn | 0929-6646 |
language | English |
last_indexed | 2024-12-22T22:46:22Z |
publishDate | 2020-04-01 |
publisher | Elsevier |
record_format | Article |
series | Journal of the Formosan Medical Association |
spelling | doaj.art-08729b3abce94a509155e6a16a07e6472022-12-21T18:10:05ZengElsevierJournal of the Formosan Medical Association0929-66462020-04-011194781792Talc exposure and risk of stomach cancer: Systematic review and meta-analysis of occupational cohort studiesChe-Jui Chang0Yu-Kang Tu1Pau-Chung Chen2Hsiao-Yu Yang3Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan; Department of Family Medicine, National Taiwan University Hospital, Taipei, TaiwanDepartment of Public Health, National Taiwan University College of Public Health, Taipei, Taiwan; Institute of Epidemiology and Preventive Medicine, National Taiwan University College of Public Health, Taipei, TaiwanInstitute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan; Department of Public Health, National Taiwan University College of Public Health, Taipei, Taiwan; Department of Environmental and Occupational Medicine, National Taiwan University Hospital, Taipei, Taiwan; Department of Environmental and Occupational Medicine, National Taiwan University College of Medicine, Taipei, TaiwanInstitute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan; Department of Public Health, National Taiwan University College of Public Health, Taipei, Taiwan; Department of Environmental and Occupational Medicine, National Taiwan University Hospital, Taipei, Taiwan; Corresponding author. Department of Public Health, Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, No. 17 Xuzhou Road, Taipei, 100, Taiwan.Background/purpose: Talc powder is widely used in various industries, but the carcinogenic effects associated with talc are not well understood. The objective of this study was to estimate the risk of stomach cancer after occupational talc exposure. Methods: We conducted a meta-analysis was performed to calculate the meta-relative risk (mRR) of stomach cancer. We searched the MEDLINE, EMBASE, CNKI and Wanfang Data databases for publications prior to January 1, 2017 using talc, cancer, and mortality as the search terms. Only cohort studies with occupational talc exposure and stomach cancer statistics were included. Results: All pooled analyses were based on random-effects models. We selected 13 observational studies (12 publications) for the meta-analysis, and heterogeneity was observed among studies. Workers exposed to all forms of talc had a significantly increased mRR of 1.21 (95% CI: 1.03—1.42, p = 0.02) for stomach cancer. Workers exposed to talc not containing asbestiform fibers also had an increased mRR of 1.26 (95% CI: 0.97—1.63, p = 0.09). Conclusion: The available data showed a positive association between occupational talc exposure and risk of stomach cancer. The association between talc not containing asbestiform fibers and risk of stomach cancer was not significant. Further epidemiological studies are required to evaluate the safety of talc. Keywords: Talcum powder, Asbestos, Gastric cancer, Mortalityhttp://www.sciencedirect.com/science/article/pii/S092966461830353X |
spellingShingle | Che-Jui Chang Yu-Kang Tu Pau-Chung Chen Hsiao-Yu Yang Talc exposure and risk of stomach cancer: Systematic review and meta-analysis of occupational cohort studies Journal of the Formosan Medical Association |
title | Talc exposure and risk of stomach cancer: Systematic review and meta-analysis of occupational cohort studies |
title_full | Talc exposure and risk of stomach cancer: Systematic review and meta-analysis of occupational cohort studies |
title_fullStr | Talc exposure and risk of stomach cancer: Systematic review and meta-analysis of occupational cohort studies |
title_full_unstemmed | Talc exposure and risk of stomach cancer: Systematic review and meta-analysis of occupational cohort studies |
title_short | Talc exposure and risk of stomach cancer: Systematic review and meta-analysis of occupational cohort studies |
title_sort | talc exposure and risk of stomach cancer systematic review and meta analysis of occupational cohort studies |
url | http://www.sciencedirect.com/science/article/pii/S092966461830353X |
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