Effect of Green Tea Mucoadhesive Paste on Recurrent Aphthous Stomatitis Treatment
<strong>Introduction:</strong> Recurrent aphthous stomatitis (RAS) is a common oral disease, which presents as painful and recurrent single or multiple ulcers in the oral mucosa. This condition is an idiopathic disease and has no definitive cure; accordingly, it is very important to find...
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Mashhad University of Medical Sciences
2020-09-01
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| Series: | Journal of Mashhad Dental School |
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| Online Access: | http://jmds.mums.ac.ir/article_15810_52d2882becdbcb9bdbf43d468a9324c0.pdf |
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| author | Atekeh Movaghari pour Payam Khazaeli Nazanin Kamyab Mahsa Pourzamani Fatemehsadat Moeinzadeh Mahmood Sheikh Fathollahi |
| author_facet | Atekeh Movaghari pour Payam Khazaeli Nazanin Kamyab Mahsa Pourzamani Fatemehsadat Moeinzadeh Mahmood Sheikh Fathollahi |
| author_sort | Atekeh Movaghari pour |
| collection | DOAJ |
| description | <strong>Introduction:</strong> Recurrent aphthous stomatitis (RAS) is a common oral disease, which presents as painful and recurrent single or multiple ulcers in the oral mucosa. This condition is an idiopathic disease and has no definitive cure; accordingly, it is very important to find a drug to control the disease. Since green tea is a rich source of antioxidant and has an anti-inflammatory effect, this study was aimed to determine the effect of a mucoadhesive paste, containing green tea extract, on RAS. <br /><strong>Materials and Methods:</strong> This double-blind, placebo-controlled clinical trial was conducted on 52 patients with RAS. The study population was randomly divided into two groups of intervention (using a mucoadhesivepaste containing green tea extract) and placebo (using a mucoadhesive paste without drug). They used mucoadhesive paste three times a day for 10 days. Pain severity was measured based on the visual analog scale at the beginning of the study (day zero) and 1, 6, and 10 days post-intervention. In addition, the lesion size was measured using a probe. The data were analyzed in SPSS software (version 21) using two-way repeated measures ANOVA. <br /><strong>Results:</strong> According to the results, pain and recovery time were significantly lower in the intervention group than in the control group (<em>p < /em><0.05). However, the ulcer size did not show any statistically significant difference between the two groups over time (<em>p < /em>>0.05). <br /><strong>Conclusion:</strong> As the findings indicated, the use of mucoadhesivepaste, containing green tea extract, can reduce the pain severity and healing time of RAS. However, it was not effective in reducing the size of lesions.</em></em> |
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| id | doaj.art-0872b1a5fce34eef8eb210da8841ea7b |
| institution | Directory Open Access Journal |
| issn | 1560-9286 2008-2347 |
| language | fas |
| last_indexed | 2024-12-14T00:52:13Z |
| publishDate | 2020-09-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Journal of Mashhad Dental School |
| spelling | doaj.art-0872b1a5fce34eef8eb210da8841ea7b2022-12-21T23:23:45ZfasMashhad University of Medical SciencesJournal of Mashhad Dental School1560-92862008-23472020-09-0144327928810.22038/jmds.2020.46254.187615810Effect of Green Tea Mucoadhesive Paste on Recurrent Aphthous Stomatitis TreatmentAtekeh Movaghari pour0Payam Khazaeli1Nazanin Kamyab2Mahsa Pourzamani3Fatemehsadat Moeinzadeh4Mahmood Sheikh Fathollahi5Assistant Professor of Oral & Maxillofacial Medicine, Department of Oral Medicine, School of Dentistry, Rafsanjan University of Medical Sciences, Rafsanjan, IranProfessor of Pharmaceutics, Department of pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, Kerman University of Medical Sciences, Kerman, IranAssistant Professor of Oral & Maxillofacial Medicine, Department of Oral Medicine, School of Dentistry, Rafsanjan University of Medical Sciences, Rafsanjan, IranAssistant Professor of Oral & Maxillofacial Medicine, School of Dentistry, Khorasan Shomali University of Medical Sciences, Bojnourd, IranDentist, School of Dentistry, Rafsanjan University of Medical Sciences, Rafsanjan, IranAssistant Professor of Biostatistics, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran<strong>Introduction:</strong> Recurrent aphthous stomatitis (RAS) is a common oral disease, which presents as painful and recurrent single or multiple ulcers in the oral mucosa. This condition is an idiopathic disease and has no definitive cure; accordingly, it is very important to find a drug to control the disease. Since green tea is a rich source of antioxidant and has an anti-inflammatory effect, this study was aimed to determine the effect of a mucoadhesive paste, containing green tea extract, on RAS. <br /><strong>Materials and Methods:</strong> This double-blind, placebo-controlled clinical trial was conducted on 52 patients with RAS. The study population was randomly divided into two groups of intervention (using a mucoadhesivepaste containing green tea extract) and placebo (using a mucoadhesive paste without drug). They used mucoadhesive paste three times a day for 10 days. Pain severity was measured based on the visual analog scale at the beginning of the study (day zero) and 1, 6, and 10 days post-intervention. In addition, the lesion size was measured using a probe. The data were analyzed in SPSS software (version 21) using two-way repeated measures ANOVA. <br /><strong>Results:</strong> According to the results, pain and recovery time were significantly lower in the intervention group than in the control group (<em>p < /em><0.05). However, the ulcer size did not show any statistically significant difference between the two groups over time (<em>p < /em>>0.05). <br /><strong>Conclusion:</strong> As the findings indicated, the use of mucoadhesivepaste, containing green tea extract, can reduce the pain severity and healing time of RAS. However, it was not effective in reducing the size of lesions.</em></em>http://jmds.mums.ac.ir/article_15810_52d2882becdbcb9bdbf43d468a9324c0.pdfrecurrent aphthous stomatitis (ras)green teamucoadhesive |
| spellingShingle | Atekeh Movaghari pour Payam Khazaeli Nazanin Kamyab Mahsa Pourzamani Fatemehsadat Moeinzadeh Mahmood Sheikh Fathollahi Effect of Green Tea Mucoadhesive Paste on Recurrent Aphthous Stomatitis Treatment Journal of Mashhad Dental School recurrent aphthous stomatitis (ras) green tea mucoadhesive |
| title | Effect of Green Tea Mucoadhesive Paste on Recurrent Aphthous Stomatitis Treatment |
| title_full | Effect of Green Tea Mucoadhesive Paste on Recurrent Aphthous Stomatitis Treatment |
| title_fullStr | Effect of Green Tea Mucoadhesive Paste on Recurrent Aphthous Stomatitis Treatment |
| title_full_unstemmed | Effect of Green Tea Mucoadhesive Paste on Recurrent Aphthous Stomatitis Treatment |
| title_short | Effect of Green Tea Mucoadhesive Paste on Recurrent Aphthous Stomatitis Treatment |
| title_sort | effect of green tea mucoadhesive paste on recurrent aphthous stomatitis treatment |
| topic | recurrent aphthous stomatitis (ras) green tea mucoadhesive |
| url | http://jmds.mums.ac.ir/article_15810_52d2882becdbcb9bdbf43d468a9324c0.pdf |
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