Combinatorial metabolic engineering of Bacillus subtilis enables the efficient biosynthesis of isoquercitrin from quercetin

Combinatorial metabolic engineering of Bacillus subtilis enables the efficient biosynthesis of isoquercitrin from quercetin

Abstract Background Isoquercitrin (quercetin-3-O-β-D-glucopyranoside) has exhibited promising therapeutic potentials as cardioprotective, anti-diabetic, anti-cancer, and anti-viral agents. However, its structural complexity and limited natural abundance make both bulk chemical synthesis and extracti...

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Bibliographic Details
Main Authors:	Tengfei Niu, Chaokang Huang, Rufeng Wang, Li Yang, Shujuan Zhao, Zhengtao Wang
Format:	Article
Language:	English
Published:	BMC 2024-04-01
Series:	Microbial Cell Factories
Subjects:	Isoquercitrin UDP-glucose Combinatorial metabolic engineering Biotransformation Bacillus subtilis
Online Access:	https://doi.org/10.1186/s12934-024-02390-5

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