Dual molecular mechanism of catalase in cancer and resistance to chemotherapy
Catalase is the one of the most important antioxidant enzymes that is found abundantly in liver and kidney. The alteration in activity and function this latter enzyme are widely investigated in various types of cancer to understand the cancer mechanism and its treatment. The changes in the catalase...
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| Format: | Article |
| Language: | fas |
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Golestan University of Medical Sciences
2016-06-01
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| Series: | مجله دانشگاه علوم پزشکی گرگان |
| Subjects: | |
| Online Access: | http://goums.ac.ir/journal/browse.php?a_code=A-10-1-897&slc_lang=en&sid=1 |
| _version_ | 1818663271298760704 |
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| author | Gholamian A Divsalar A |
| author_facet | Gholamian A Divsalar A |
| author_sort | Gholamian A |
| collection | DOAJ |
| description | Catalase is the one of the most important antioxidant enzymes that is found abundantly in liver and kidney. The alteration in activity and function this latter enzyme are widely investigated in various types of cancer to understand the cancer mechanism and its treatment. The changes in the catalase activity levels in a variety of cancer cells is as a specific property of tumor tissues due to the reducting catalase activity at mRNA level. In this review, various reports that examined the alterations in catalase activity and resistance to chemotherapy and its complications in the literature are summarized and discussed. Due to the important role of hydrogen peroxide in various stages of cancer process, catalase alters this process by detoxification of hydrogen peroxide. Chemotherapy increase free radicals to destroy the tumor cells, then, catalase activity reduced their impact on cancer cells. On the other hand, it might be concluded that production of drug resistance in chemotherapy is resulted due to increasing catalase activity. Therefor it seems catalase has contradictory influence on the treatment and development of cancer. |
| first_indexed | 2024-12-17T05:14:12Z |
| format | Article |
| id | doaj.art-0873a76eefc74ef699de6d42bb2e942a |
| institution | Directory Open Access Journal |
| issn | 1562-4765 2008-4080 |
| language | fas |
| last_indexed | 2024-12-17T05:14:12Z |
| publishDate | 2016-06-01 |
| publisher | Golestan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشگاه علوم پزشکی گرگان |
| spelling | doaj.art-0873a76eefc74ef699de6d42bb2e942a2022-12-21T22:02:10ZfasGolestan University of Medical Sciencesمجله دانشگاه علوم پزشکی گرگان1562-47652008-40802016-06-01182111Dual molecular mechanism of catalase in cancer and resistance to chemotherapyGholamian A0Divsalar A1 M.Sc in Biochemistry‚ Department of Cell and Molecular Biology‚ Faculty of Biological Sciences‚ Kharazmi University, Tehran, Iran Assistant Professor, Department of Cell and Molecular Biology‚ Faculty of Biological Sciences‚ Kharazmi University, Tehran, Iran Catalase is the one of the most important antioxidant enzymes that is found abundantly in liver and kidney. The alteration in activity and function this latter enzyme are widely investigated in various types of cancer to understand the cancer mechanism and its treatment. The changes in the catalase activity levels in a variety of cancer cells is as a specific property of tumor tissues due to the reducting catalase activity at mRNA level. In this review, various reports that examined the alterations in catalase activity and resistance to chemotherapy and its complications in the literature are summarized and discussed. Due to the important role of hydrogen peroxide in various stages of cancer process, catalase alters this process by detoxification of hydrogen peroxide. Chemotherapy increase free radicals to destroy the tumor cells, then, catalase activity reduced their impact on cancer cells. On the other hand, it might be concluded that production of drug resistance in chemotherapy is resulted due to increasing catalase activity. Therefor it seems catalase has contradictory influence on the treatment and development of cancer.http://goums.ac.ir/journal/browse.php?a_code=A-10-1-897&slc_lang=en&sid=1CatalaseCancerHydrogen peroxideChemotherapy |
| spellingShingle | Gholamian A Divsalar A Dual molecular mechanism of catalase in cancer and resistance to chemotherapy مجله دانشگاه علوم پزشکی گرگان Catalase Cancer Hydrogen peroxide Chemotherapy |
| title | Dual molecular mechanism of catalase in cancer and resistance to chemotherapy |
| title_full | Dual molecular mechanism of catalase in cancer and resistance to chemotherapy |
| title_fullStr | Dual molecular mechanism of catalase in cancer and resistance to chemotherapy |
| title_full_unstemmed | Dual molecular mechanism of catalase in cancer and resistance to chemotherapy |
| title_short | Dual molecular mechanism of catalase in cancer and resistance to chemotherapy |
| title_sort | dual molecular mechanism of catalase in cancer and resistance to chemotherapy |
| topic | Catalase Cancer Hydrogen peroxide Chemotherapy |
| url | http://goums.ac.ir/journal/browse.php?a_code=A-10-1-897&slc_lang=en&sid=1 |
| work_keys_str_mv | AT gholamiana dualmolecularmechanismofcatalaseincancerandresistancetochemotherapy AT divsalara dualmolecularmechanismofcatalaseincancerandresistancetochemotherapy |