An analysis of the significance of the Tre2/Bub2/CDC 16 (TBC) domain protein family 8 in colorectal cancer
Abstract The TBC (Tre-2/Bub2/Cdc16, TBC) structural domain is now considered as one of the factors potentially regulating tumor progression. However, to date, studies on the relationship between TBC structural domains and tumors are limited. In this study, we identified the role of TBC1 domain famil...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-08-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-15629-1 |
| _version_ | 1817968033061142528 |
|---|---|
| author | Yuan-jie Liu Jie-pin Li Hui-ru Li Shu-hong Zeng Yu-gen Chen Mei Han Qian-wen Ye Jin-yong Zhou Shen-lin Liu Xi Zou |
| author_facet | Yuan-jie Liu Jie-pin Li Hui-ru Li Shu-hong Zeng Yu-gen Chen Mei Han Qian-wen Ye Jin-yong Zhou Shen-lin Liu Xi Zou |
| author_sort | Yuan-jie Liu |
| collection | DOAJ |
| description | Abstract The TBC (Tre-2/Bub2/Cdc16, TBC) structural domain is now considered as one of the factors potentially regulating tumor progression. However, to date, studies on the relationship between TBC structural domains and tumors are limited. In this study, we identified the role of TBC1 domain family member 8 (TBC1D8) as an oncogene in colorectal cancer (CRC) by least absolute shrinkage and selection operator (LASSO) and Cox regression analysis, showing that TBC1D8 may independently predict CRC outcome. Functional enrichment and single-cell analysis showed that TBC1D8 levels were associated with hypoxia. TBC1D8 levels were also positively correlated with M2 macrophage infiltration, which may have a complex association with hypoxia. Taken together, these results show that the TBC1D8 gene is involved in colorectal carcinogenesis, and the underlying molecular mechanisms may include hypoxia and immune cell infiltration. |
| first_indexed | 2024-04-13T20:03:39Z |
| format | Article |
| id | doaj.art-0874671344e2462ab73a5dce611f97c4 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T20:03:39Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-0874671344e2462ab73a5dce611f97c42022-12-22T02:32:07ZengNature PortfolioScientific Reports2045-23222022-08-0112111810.1038/s41598-022-15629-1An analysis of the significance of the Tre2/Bub2/CDC 16 (TBC) domain protein family 8 in colorectal cancerYuan-jie Liu0Jie-pin Li1Hui-ru Li2Shu-hong Zeng3Yu-gen Chen4Mei Han5Qian-wen Ye6Jin-yong Zhou7Shen-lin Liu8Xi Zou9Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese MedicineAbstract The TBC (Tre-2/Bub2/Cdc16, TBC) structural domain is now considered as one of the factors potentially regulating tumor progression. However, to date, studies on the relationship between TBC structural domains and tumors are limited. In this study, we identified the role of TBC1 domain family member 8 (TBC1D8) as an oncogene in colorectal cancer (CRC) by least absolute shrinkage and selection operator (LASSO) and Cox regression analysis, showing that TBC1D8 may independently predict CRC outcome. Functional enrichment and single-cell analysis showed that TBC1D8 levels were associated with hypoxia. TBC1D8 levels were also positively correlated with M2 macrophage infiltration, which may have a complex association with hypoxia. Taken together, these results show that the TBC1D8 gene is involved in colorectal carcinogenesis, and the underlying molecular mechanisms may include hypoxia and immune cell infiltration.https://doi.org/10.1038/s41598-022-15629-1 |
| spellingShingle | Yuan-jie Liu Jie-pin Li Hui-ru Li Shu-hong Zeng Yu-gen Chen Mei Han Qian-wen Ye Jin-yong Zhou Shen-lin Liu Xi Zou An analysis of the significance of the Tre2/Bub2/CDC 16 (TBC) domain protein family 8 in colorectal cancer Scientific Reports |
| title | An analysis of the significance of the Tre2/Bub2/CDC 16 (TBC) domain protein family 8 in colorectal cancer |
| title_full | An analysis of the significance of the Tre2/Bub2/CDC 16 (TBC) domain protein family 8 in colorectal cancer |
| title_fullStr | An analysis of the significance of the Tre2/Bub2/CDC 16 (TBC) domain protein family 8 in colorectal cancer |
| title_full_unstemmed | An analysis of the significance of the Tre2/Bub2/CDC 16 (TBC) domain protein family 8 in colorectal cancer |
| title_short | An analysis of the significance of the Tre2/Bub2/CDC 16 (TBC) domain protein family 8 in colorectal cancer |
| title_sort | analysis of the significance of the tre2 bub2 cdc 16 tbc domain protein family 8 in colorectal cancer |
| url | https://doi.org/10.1038/s41598-022-15629-1 |
| work_keys_str_mv | AT yuanjieliu ananalysisofthesignificanceofthetre2bub2cdc16tbcdomainproteinfamily8incolorectalcancer AT jiepinli ananalysisofthesignificanceofthetre2bub2cdc16tbcdomainproteinfamily8incolorectalcancer AT huiruli ananalysisofthesignificanceofthetre2bub2cdc16tbcdomainproteinfamily8incolorectalcancer AT shuhongzeng ananalysisofthesignificanceofthetre2bub2cdc16tbcdomainproteinfamily8incolorectalcancer AT yugenchen ananalysisofthesignificanceofthetre2bub2cdc16tbcdomainproteinfamily8incolorectalcancer AT meihan ananalysisofthesignificanceofthetre2bub2cdc16tbcdomainproteinfamily8incolorectalcancer AT qianwenye ananalysisofthesignificanceofthetre2bub2cdc16tbcdomainproteinfamily8incolorectalcancer AT jinyongzhou ananalysisofthesignificanceofthetre2bub2cdc16tbcdomainproteinfamily8incolorectalcancer AT shenlinliu ananalysisofthesignificanceofthetre2bub2cdc16tbcdomainproteinfamily8incolorectalcancer AT xizou ananalysisofthesignificanceofthetre2bub2cdc16tbcdomainproteinfamily8incolorectalcancer AT yuanjieliu analysisofthesignificanceofthetre2bub2cdc16tbcdomainproteinfamily8incolorectalcancer AT jiepinli analysisofthesignificanceofthetre2bub2cdc16tbcdomainproteinfamily8incolorectalcancer AT huiruli analysisofthesignificanceofthetre2bub2cdc16tbcdomainproteinfamily8incolorectalcancer AT shuhongzeng analysisofthesignificanceofthetre2bub2cdc16tbcdomainproteinfamily8incolorectalcancer AT yugenchen analysisofthesignificanceofthetre2bub2cdc16tbcdomainproteinfamily8incolorectalcancer AT meihan analysisofthesignificanceofthetre2bub2cdc16tbcdomainproteinfamily8incolorectalcancer AT qianwenye analysisofthesignificanceofthetre2bub2cdc16tbcdomainproteinfamily8incolorectalcancer AT jinyongzhou analysisofthesignificanceofthetre2bub2cdc16tbcdomainproteinfamily8incolorectalcancer AT shenlinliu analysisofthesignificanceofthetre2bub2cdc16tbcdomainproteinfamily8incolorectalcancer AT xizou analysisofthesignificanceofthetre2bub2cdc16tbcdomainproteinfamily8incolorectalcancer |