Evaluation of Pulmonary Hypertension with CMR: Pulmonary Hypertension Patients and Healthy Volunteers Control Study
Background and objective The clinical course of pulmonary hypertension (PH) is one of progressive deterioration interspersed with episodes of acute decompensation. It is difficult to predict when patients will die because death may come either suddenly or slowly due to progressive heart failure. The...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | zho |
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2016-05-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2016.05.07 |
| _version_ | 1818606130956337152 |
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| author | Meng WANG Zhenwen YANG Zhang ZHANG Dong LI Fan YANG Tielian YU |
| author_facet | Meng WANG Zhenwen YANG Zhang ZHANG Dong LI Fan YANG Tielian YU |
| author_sort | Meng WANG |
| collection | DOAJ |
| description | Background and objective The clinical course of pulmonary hypertension (PH) is one of progressive deterioration interspersed with episodes of acute decompensation. It is difficult to predict when patients will die because death may come either suddenly or slowly due to progressive heart failure. The aim of this study is to investigate morphology, function and hemodynamics in PH, compared with healthy people, and to investigate the clinical value of detection of PH by use of cardiac magnetic resonance (CMR) parameters. Methods CMR was performed in 56 PH patients collected from Tianjin Medical University General Hospital from January 2012 to December 2014 and 22 healthy controls. The following parameters were calculated: right ventricle (RV) end-diastolic volume (EDV), end-systolic volume (ESV), ejection fraction (EF), myocardial mass (MM), RV fractional area change (RVFAC), interventricular septal curvature (CIVS), left ventricular free wall curvature (CFW), and CIVS/CFW, main pulmonary artery (MPA) positive peak velocity, maximal area, minimal area and distensibility. Comparisons of CMR measurements between PH patients and controls were analyzed by using the student t-tests. Receiver operating characteristic (ROC) curve analysis was used to compare the PH diagnostic abilities for four parameters (MPA positive peak velocity, distensibility, curvature ratio, and RVFAC) and combined CMR parameter. P<0.05 was considered significant. Results Compared with healthy controls, RV morphology, function and hemodynamics of PH group declined and deteriorate obviously. The ROC curve analysis showed that among the four parameters distensibility of MPA had the highest AUC value (AUC=0.95). Additionally, combined CMR parameter (positive peak velocity+distensibility+curvature ratio+RVFAC) had even higher AUC (AUC=0.988). Conclusion Comprehensive CMR parameters is conducive to accurately reflect the overall state RV-pulmonary circulation in patients with PH. |
| first_indexed | 2024-12-16T14:05:58Z |
| format | Article |
| id | doaj.art-08751e80703c4b56b2fba25d68c862bb |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-12-16T14:05:58Z |
| publishDate | 2016-05-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-08751e80703c4b56b2fba25d68c862bb2022-12-21T22:28:55ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872016-05-0119529329810.3779/j.issn.1009-3419.2016.05.07Evaluation of Pulmonary Hypertension with CMR: Pulmonary Hypertension
Patients and Healthy Volunteers Control StudyMeng WANG0Zhenwen YANG1Zhang ZHANG2Dong LI3Fan YANG4Tielian YU5Department of RadiologyDepartment of Cardiovascular Disease, Tianjin Medical University General Hospital, Tianjin 300052, ChinaDepartment of RadiologyDepartment of RadiologyDepartment of RadiologyDepartment of RadiologyBackground and objective The clinical course of pulmonary hypertension (PH) is one of progressive deterioration interspersed with episodes of acute decompensation. It is difficult to predict when patients will die because death may come either suddenly or slowly due to progressive heart failure. The aim of this study is to investigate morphology, function and hemodynamics in PH, compared with healthy people, and to investigate the clinical value of detection of PH by use of cardiac magnetic resonance (CMR) parameters. Methods CMR was performed in 56 PH patients collected from Tianjin Medical University General Hospital from January 2012 to December 2014 and 22 healthy controls. The following parameters were calculated: right ventricle (RV) end-diastolic volume (EDV), end-systolic volume (ESV), ejection fraction (EF), myocardial mass (MM), RV fractional area change (RVFAC), interventricular septal curvature (CIVS), left ventricular free wall curvature (CFW), and CIVS/CFW, main pulmonary artery (MPA) positive peak velocity, maximal area, minimal area and distensibility. Comparisons of CMR measurements between PH patients and controls were analyzed by using the student t-tests. Receiver operating characteristic (ROC) curve analysis was used to compare the PH diagnostic abilities for four parameters (MPA positive peak velocity, distensibility, curvature ratio, and RVFAC) and combined CMR parameter. P<0.05 was considered significant. Results Compared with healthy controls, RV morphology, function and hemodynamics of PH group declined and deteriorate obviously. The ROC curve analysis showed that among the four parameters distensibility of MPA had the highest AUC value (AUC=0.95). Additionally, combined CMR parameter (positive peak velocity+distensibility+curvature ratio+RVFAC) had even higher AUC (AUC=0.988). Conclusion Comprehensive CMR parameters is conducive to accurately reflect the overall state RV-pulmonary circulation in patients with PH.http://dx.doi.org/10.3779/j.issn.1009-3419.2016.05.07CardiacMagnetic resonancePulmonary hypertensionRight ventriclePulmonary artery |
| spellingShingle | Meng WANG Zhenwen YANG Zhang ZHANG Dong LI Fan YANG Tielian YU Evaluation of Pulmonary Hypertension with CMR: Pulmonary Hypertension Patients and Healthy Volunteers Control Study Chinese Journal of Lung Cancer Cardiac Magnetic resonance Pulmonary hypertension Right ventricle Pulmonary artery |
| title | Evaluation of Pulmonary Hypertension with CMR: Pulmonary Hypertension
Patients and Healthy Volunteers Control Study |
| title_full | Evaluation of Pulmonary Hypertension with CMR: Pulmonary Hypertension
Patients and Healthy Volunteers Control Study |
| title_fullStr | Evaluation of Pulmonary Hypertension with CMR: Pulmonary Hypertension
Patients and Healthy Volunteers Control Study |
| title_full_unstemmed | Evaluation of Pulmonary Hypertension with CMR: Pulmonary Hypertension
Patients and Healthy Volunteers Control Study |
| title_short | Evaluation of Pulmonary Hypertension with CMR: Pulmonary Hypertension
Patients and Healthy Volunteers Control Study |
| title_sort | evaluation of pulmonary hypertension with cmr pulmonary hypertension
patients and healthy volunteers control study |
| topic | Cardiac Magnetic resonance Pulmonary hypertension Right ventricle Pulmonary artery |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2016.05.07 |
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