Emerging Precision Medicine Approaches for Lung Neuroendocrine Tumors
Well-differentiated lung neuroendocrine tumors (LNETs) are heterogeneous cancers that are increasing in incidence. Treatment options for LNETs have expanded in recent years, and our knowledge of the molecular subtypes has also advanced. Multidisciplinary teams have an established role in personalizi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/23/5575 |
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| author | Claire K. Mulvey |
| author_facet | Claire K. Mulvey |
| author_sort | Claire K. Mulvey |
| collection | DOAJ |
| description | Well-differentiated lung neuroendocrine tumors (LNETs) are heterogeneous cancers that are increasing in incidence. Treatment options for LNETs have expanded in recent years, and our knowledge of the molecular subtypes has also advanced. Multidisciplinary teams have an established role in personalizing the best treatment for individual patients. Other precision medicine approaches for the treatment of LNETs have lagged behind those for non-small-cell lung cancer, with only rare actionable molecular alterations identified and few established predictive factors to guide therapy selection. However, as summarized in this review, there is increasing potential for personalized treatment of patients with LNETs. In particular, advances in radiotheragnostics may allow us to tailor the treatment of individual patients with NETs in the coming years. These advances may soon deliver the promise of more effective, less toxic treatments and better outcomes for patients with these increasingly common cancers. |
| first_indexed | 2024-03-09T01:53:27Z |
| format | Article |
| id | doaj.art-0875507a6ce14dcd8c33ff45cec9e968 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T01:53:27Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-0875507a6ce14dcd8c33ff45cec9e9682023-12-08T15:12:35ZengMDPI AGCancers2072-66942023-11-011523557510.3390/cancers15235575Emerging Precision Medicine Approaches for Lung Neuroendocrine TumorsClaire K. Mulvey0Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA 94158, USAWell-differentiated lung neuroendocrine tumors (LNETs) are heterogeneous cancers that are increasing in incidence. Treatment options for LNETs have expanded in recent years, and our knowledge of the molecular subtypes has also advanced. Multidisciplinary teams have an established role in personalizing the best treatment for individual patients. Other precision medicine approaches for the treatment of LNETs have lagged behind those for non-small-cell lung cancer, with only rare actionable molecular alterations identified and few established predictive factors to guide therapy selection. However, as summarized in this review, there is increasing potential for personalized treatment of patients with LNETs. In particular, advances in radiotheragnostics may allow us to tailor the treatment of individual patients with NETs in the coming years. These advances may soon deliver the promise of more effective, less toxic treatments and better outcomes for patients with these increasingly common cancers.https://www.mdpi.com/2072-6694/15/23/5575lung neuroendocrine tumorscarcinoid tumorsprecision medicinetheragnostics |
| spellingShingle | Claire K. Mulvey Emerging Precision Medicine Approaches for Lung Neuroendocrine Tumors Cancers lung neuroendocrine tumors carcinoid tumors precision medicine theragnostics |
| title | Emerging Precision Medicine Approaches for Lung Neuroendocrine Tumors |
| title_full | Emerging Precision Medicine Approaches for Lung Neuroendocrine Tumors |
| title_fullStr | Emerging Precision Medicine Approaches for Lung Neuroendocrine Tumors |
| title_full_unstemmed | Emerging Precision Medicine Approaches for Lung Neuroendocrine Tumors |
| title_short | Emerging Precision Medicine Approaches for Lung Neuroendocrine Tumors |
| title_sort | emerging precision medicine approaches for lung neuroendocrine tumors |
| topic | lung neuroendocrine tumors carcinoid tumors precision medicine theragnostics |
| url | https://www.mdpi.com/2072-6694/15/23/5575 |
| work_keys_str_mv | AT clairekmulvey emergingprecisionmedicineapproachesforlungneuroendocrinetumors |