| Summary: | The gold standard diagnostic method for gastrointestinal infections is stool culture, which has limited sensitivity and long turnaround time. Infection diagnosis recently shifted to syndrome-based panel assays. This study employed the FilmArray<sup>®</sup> Gastrointestinal Panel, which detects 22 pathogens simultaneously, to investigate gastrointestinal infection and pathogen distribution in 91 stool samples of patients hospitalized at the Tzafon Medical Center, Israel, during 2020, and to compare the clinical and demographic data of negative vs. positive samples. Among the 61 positive samples (67%), the most common pathogen was <i>Campylobacter</i> (34.4%). Positive test results were associated with a slightly younger patient age (<i>p</i> = 0.012), significantly higher post-diagnosis use of antibiotics (63.9% vs. 36.7%; <i>p</i> = 0.014), and shorter length of stay and time to discharge (<i>p</i> = 0.035, <i>p</i> = 0.003, respectively) than negative test results. To conclude, the FilmArray<sup>®</sup> Gastrointestinal Panel enabled the early identification of causative infectious agents and enhanced clinical management and outcomes.
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