MSNCs and MgO-MSNCs as drug delivery systems to control the adsorption kinetics and release rate of indometacin
Mesoporous silica cocoon materials (MSNCs) and MgO doped mesoporous silica cocoons (MgO-MSNCs) with the cocoon-like hierarchical morphology and different alkalinities were synthesized as carriers for acidic drugs. Indomethacin (IMC) was selected as a model drug and loaded into carriers. All material...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-05-01
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| Series: | Asian Journal of Pharmaceutical Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1818087618301776 |
| _version_ | 1819028005150785536 |
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| author | Xin Zheng Shuang Feng Xiudan Wang Zhenning Shi Yuling Mao Qinfu Zhao Siling Wang |
| author_facet | Xin Zheng Shuang Feng Xiudan Wang Zhenning Shi Yuling Mao Qinfu Zhao Siling Wang |
| author_sort | Xin Zheng |
| collection | DOAJ |
| description | Mesoporous silica cocoon materials (MSNCs) and MgO doped mesoporous silica cocoons (MgO-MSNCs) with the cocoon-like hierarchical morphology and different alkalinities were synthesized as carriers for acidic drugs. Indomethacin (IMC) was selected as a model drug and loaded into carriers. All materials and the drug-loaded samples were characterized by nitrogen adsorption, FTIR spectroscopy, transmission electron microscopy (TEM), powder X-Ray diffraction (XRD) and differential scanning calorimetry (DSC). The effect of the Mg/Si molar ratio on the kinetics and equilibrium of IMC adsorption on MgO-MSNCs was thoroughly examined, and it was found that the increase in the Mg/Si molar ratio resulted in an increasing IMC adsorption rate due to the increased affinity between alkaline MgO-MSNCs and weak acid IMC. The adsorption kinetics fitted a pseudo second-order model well. The Freundlich isotherm showed a better fit, indicating that the coverage of IMC on the surface of MgO-MSNCs was heterogeneous. The maximum adsorption capacity of adsorbent was calculated by the Langmuir isotherm equation. The Temkin equation provided further support that the IMC adsorption on MgO-MSNCs was dominated by a chemisorption process. MgO-MSNCs also have the advantage of allowing an adjustment of the drug release rate of weak acid drug. The cytotoxicity assay indicated good biocompatibility of MgO-MSNCs. Our research on MgO-MSNCs carriers demonstrated their potential therapeutic benefit for safe and effective management of IMC adsorption and in vitro release. Keywords: MSNCs, MgO-MSNCs, Indometacin, Adsorption, Release rate |
| first_indexed | 2024-12-21T05:51:29Z |
| format | Article |
| id | doaj.art-08761c2fa9914981a977d0c282cd894d |
| institution | Directory Open Access Journal |
| issn | 1818-0876 |
| language | English |
| last_indexed | 2024-12-21T05:51:29Z |
| publishDate | 2019-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-08761c2fa9914981a977d0c282cd894d2022-12-21T19:13:57ZengElsevierAsian Journal of Pharmaceutical Sciences1818-08762019-05-01143275286MSNCs and MgO-MSNCs as drug delivery systems to control the adsorption kinetics and release rate of indometacinXin Zheng0Shuang Feng1Xiudan Wang2Zhenning Shi3Yuling Mao4Qinfu Zhao5Siling Wang6Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, ChinaDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, ChinaDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, ChinaDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, ChinaDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, ChinaDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China; Corresponding authors at. Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, China. Tel.: +86 24 43520537Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China; Corresponding authors at. Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, China. Tel.: +86 24 43520537Mesoporous silica cocoon materials (MSNCs) and MgO doped mesoporous silica cocoons (MgO-MSNCs) with the cocoon-like hierarchical morphology and different alkalinities were synthesized as carriers for acidic drugs. Indomethacin (IMC) was selected as a model drug and loaded into carriers. All materials and the drug-loaded samples were characterized by nitrogen adsorption, FTIR spectroscopy, transmission electron microscopy (TEM), powder X-Ray diffraction (XRD) and differential scanning calorimetry (DSC). The effect of the Mg/Si molar ratio on the kinetics and equilibrium of IMC adsorption on MgO-MSNCs was thoroughly examined, and it was found that the increase in the Mg/Si molar ratio resulted in an increasing IMC adsorption rate due to the increased affinity between alkaline MgO-MSNCs and weak acid IMC. The adsorption kinetics fitted a pseudo second-order model well. The Freundlich isotherm showed a better fit, indicating that the coverage of IMC on the surface of MgO-MSNCs was heterogeneous. The maximum adsorption capacity of adsorbent was calculated by the Langmuir isotherm equation. The Temkin equation provided further support that the IMC adsorption on MgO-MSNCs was dominated by a chemisorption process. MgO-MSNCs also have the advantage of allowing an adjustment of the drug release rate of weak acid drug. The cytotoxicity assay indicated good biocompatibility of MgO-MSNCs. Our research on MgO-MSNCs carriers demonstrated their potential therapeutic benefit for safe and effective management of IMC adsorption and in vitro release. Keywords: MSNCs, MgO-MSNCs, Indometacin, Adsorption, Release ratehttp://www.sciencedirect.com/science/article/pii/S1818087618301776 |
| spellingShingle | Xin Zheng Shuang Feng Xiudan Wang Zhenning Shi Yuling Mao Qinfu Zhao Siling Wang MSNCs and MgO-MSNCs as drug delivery systems to control the adsorption kinetics and release rate of indometacin Asian Journal of Pharmaceutical Sciences |
| title | MSNCs and MgO-MSNCs as drug delivery systems to control the adsorption kinetics and release rate of indometacin |
| title_full | MSNCs and MgO-MSNCs as drug delivery systems to control the adsorption kinetics and release rate of indometacin |
| title_fullStr | MSNCs and MgO-MSNCs as drug delivery systems to control the adsorption kinetics and release rate of indometacin |
| title_full_unstemmed | MSNCs and MgO-MSNCs as drug delivery systems to control the adsorption kinetics and release rate of indometacin |
| title_short | MSNCs and MgO-MSNCs as drug delivery systems to control the adsorption kinetics and release rate of indometacin |
| title_sort | msncs and mgo msncs as drug delivery systems to control the adsorption kinetics and release rate of indometacin |
| url | http://www.sciencedirect.com/science/article/pii/S1818087618301776 |
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