Cardiovascular magnetic resonance-derived left ventricular mechanics—strain, cardiac power and end-systolic elastance under various inotropic states in swine
Abstract Background Cardiovascular magnetic resonance (CMR) strain imaging is an established technique to quantify myocardial deformation. However, to what extent left ventricular (LV) systolic strain, and therefore LV mechanics, reflects classical hemodynamic parameters under various inotropic stat...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-11-01
|
| Series: | Journal of Cardiovascular Magnetic Resonance |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12968-020-00679-z |
| _version_ | 1797203821031587840 |
|---|---|
| author | A. Faragli R. Tanacli C. Kolp D. Abawi T. Lapinskas C. Stehning B. Schnackenburg F. P. Lo Muzio L. Fassina B. Pieske E. Nagel H. Post S. Kelle A. Alogna |
| author_facet | A. Faragli R. Tanacli C. Kolp D. Abawi T. Lapinskas C. Stehning B. Schnackenburg F. P. Lo Muzio L. Fassina B. Pieske E. Nagel H. Post S. Kelle A. Alogna |
| author_sort | A. Faragli |
| collection | DOAJ |
| description | Abstract Background Cardiovascular magnetic resonance (CMR) strain imaging is an established technique to quantify myocardial deformation. However, to what extent left ventricular (LV) systolic strain, and therefore LV mechanics, reflects classical hemodynamic parameters under various inotropic states is still not completely clear. Therefore, the aim of this study was to investigate the correlation of LV global strain parameters measured via CMR feature tracking (CMR-FT, based on conventional cine balanced steady state free precession (bSSFP) images) with hemodynamic parameters such as cardiac index (CI), cardiac power output (CPO) and end-systolic elastance (Ees) under various inotropic states. Methods Ten anaesthetized, healthy Landrace swine were acutely instrumented closed-chest and transported to the CMR facility for measurements. After baseline measurements, two steps were performed: (1) dobutamine-stress (Dobutamine) and (2) verapamil-induced cardiovascular depression (Verapamil). During each protocol, CMR images were acquired in the short axisand apical 2Ch, 3Ch and 4Ch views. MEDIS software was utilized to analyze global longitudinal (GLS), global circumferential (GCS), and global radial strain (GRS). Results Dobutamine significantly increased heart rate, CI, CPO and Ees, while Verapamil decreased them. Absolute values of GLS, GCS and GRS accordingly increased during Dobutamine infusion, while GLS and GCS decreased during Verapamil. Linear regression analysis showed a moderate correlation between GLS, GCS and LV hemodynamic parameters, while GRS correlated poorly. Indexing global strain parameters for indirect measures of afterload, such as mean aortic pressure or wall stress, significantly improved these correlations, with GLS indexed for wall stress reflecting LV contractility as the clinically widespread LV ejection fraction. Conclusion GLS and GCS correlate accordingly with LV hemodynamics under various inotropic states in swine. Indexing strain parameters for indirect measures of afterload substantially improves this correlation, with GLS being as good as LV ejection fraction in reflecting LV contractility. CMR-FT-strain imaging may be a quick and promising tool to characterize LV hemodynamics in patients with varying degrees of LV dysfunction. |
| first_indexed | 2024-04-24T08:25:25Z |
| format | Article |
| id | doaj.art-08799bac6b13413c9887e4b1bb11fd2b |
| institution | Directory Open Access Journal |
| issn | 1532-429X |
| language | English |
| last_indexed | 2024-04-24T08:25:25Z |
| publishDate | 2020-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Cardiovascular Magnetic Resonance |
| spelling | doaj.art-08799bac6b13413c9887e4b1bb11fd2b2024-04-16T22:13:05ZengElsevierJournal of Cardiovascular Magnetic Resonance1532-429X2020-11-0122111210.1186/s12968-020-00679-zCardiovascular magnetic resonance-derived left ventricular mechanics—strain, cardiac power and end-systolic elastance under various inotropic states in swineA. Faragli0R. Tanacli1C. Kolp2D. Abawi3T. Lapinskas4C. Stehning5B. Schnackenburg6F. P. Lo Muzio7L. Fassina8B. Pieske9E. Nagel10H. Post11S. Kelle12A. Alogna13Department of Internal Medicine and Cardiology, Charité-Universitätsmedizin BerlinDepartment of Internal Medicine and Cardiology, Charité-Universitätsmedizin BerlinDepartment of Internal Medicine and Cardiology, Charité-Universitätsmedizin BerlinDepartment of Internal Medicine and Cardiology, Charité-Universitätsmedizin BerlinDepartment of Internal Medicine/Cardiology, Deutsches Herzzentrum BerlinClinical Science, Philips HealthcareClinical Science, Philips HealthcareDepartment of Surgery, Dentistry, Paediatrics and Gynaecology, University of VeronaDepartment of Electrical, Computer and Biomedical Engineering (DIII), Centre for Health Technologies (CHT), University of PaviaDepartment of Internal Medicine and Cardiology, Charité-Universitätsmedizin BerlinInstitute of Experimental and Translational Cardiac Imaging, DZHK Centre for Cardiovascular Imaging, Goethe University Hospital FrankfurtDepartment of Internal Medicine and Cardiology, Charité-Universitätsmedizin BerlinDepartment of Internal Medicine and Cardiology, Charité-Universitätsmedizin BerlinDepartment of Internal Medicine and Cardiology, Charité-Universitätsmedizin BerlinAbstract Background Cardiovascular magnetic resonance (CMR) strain imaging is an established technique to quantify myocardial deformation. However, to what extent left ventricular (LV) systolic strain, and therefore LV mechanics, reflects classical hemodynamic parameters under various inotropic states is still not completely clear. Therefore, the aim of this study was to investigate the correlation of LV global strain parameters measured via CMR feature tracking (CMR-FT, based on conventional cine balanced steady state free precession (bSSFP) images) with hemodynamic parameters such as cardiac index (CI), cardiac power output (CPO) and end-systolic elastance (Ees) under various inotropic states. Methods Ten anaesthetized, healthy Landrace swine were acutely instrumented closed-chest and transported to the CMR facility for measurements. After baseline measurements, two steps were performed: (1) dobutamine-stress (Dobutamine) and (2) verapamil-induced cardiovascular depression (Verapamil). During each protocol, CMR images were acquired in the short axisand apical 2Ch, 3Ch and 4Ch views. MEDIS software was utilized to analyze global longitudinal (GLS), global circumferential (GCS), and global radial strain (GRS). Results Dobutamine significantly increased heart rate, CI, CPO and Ees, while Verapamil decreased them. Absolute values of GLS, GCS and GRS accordingly increased during Dobutamine infusion, while GLS and GCS decreased during Verapamil. Linear regression analysis showed a moderate correlation between GLS, GCS and LV hemodynamic parameters, while GRS correlated poorly. Indexing global strain parameters for indirect measures of afterload, such as mean aortic pressure or wall stress, significantly improved these correlations, with GLS indexed for wall stress reflecting LV contractility as the clinically widespread LV ejection fraction. Conclusion GLS and GCS correlate accordingly with LV hemodynamics under various inotropic states in swine. Indexing strain parameters for indirect measures of afterload substantially improves this correlation, with GLS being as good as LV ejection fraction in reflecting LV contractility. CMR-FT-strain imaging may be a quick and promising tool to characterize LV hemodynamics in patients with varying degrees of LV dysfunction.https://doi.org/10.1186/s12968-020-00679-zCardiovascular magnetic resonanceFeature trackingLeft ventricular strainContractile functionPorcine modelTranslational studies |
| spellingShingle | A. Faragli R. Tanacli C. Kolp D. Abawi T. Lapinskas C. Stehning B. Schnackenburg F. P. Lo Muzio L. Fassina B. Pieske E. Nagel H. Post S. Kelle A. Alogna Cardiovascular magnetic resonance-derived left ventricular mechanics—strain, cardiac power and end-systolic elastance under various inotropic states in swine Journal of Cardiovascular Magnetic Resonance Cardiovascular magnetic resonance Feature tracking Left ventricular strain Contractile function Porcine model Translational studies |
| title | Cardiovascular magnetic resonance-derived left ventricular mechanics—strain, cardiac power and end-systolic elastance under various inotropic states in swine |
| title_full | Cardiovascular magnetic resonance-derived left ventricular mechanics—strain, cardiac power and end-systolic elastance under various inotropic states in swine |
| title_fullStr | Cardiovascular magnetic resonance-derived left ventricular mechanics—strain, cardiac power and end-systolic elastance under various inotropic states in swine |
| title_full_unstemmed | Cardiovascular magnetic resonance-derived left ventricular mechanics—strain, cardiac power and end-systolic elastance under various inotropic states in swine |
| title_short | Cardiovascular magnetic resonance-derived left ventricular mechanics—strain, cardiac power and end-systolic elastance under various inotropic states in swine |
| title_sort | cardiovascular magnetic resonance derived left ventricular mechanics strain cardiac power and end systolic elastance under various inotropic states in swine |
| topic | Cardiovascular magnetic resonance Feature tracking Left ventricular strain Contractile function Porcine model Translational studies |
| url | https://doi.org/10.1186/s12968-020-00679-z |
| work_keys_str_mv | AT afaragli cardiovascularmagneticresonancederivedleftventricularmechanicsstraincardiacpowerandendsystolicelastanceundervariousinotropicstatesinswine AT rtanacli cardiovascularmagneticresonancederivedleftventricularmechanicsstraincardiacpowerandendsystolicelastanceundervariousinotropicstatesinswine AT ckolp cardiovascularmagneticresonancederivedleftventricularmechanicsstraincardiacpowerandendsystolicelastanceundervariousinotropicstatesinswine AT dabawi cardiovascularmagneticresonancederivedleftventricularmechanicsstraincardiacpowerandendsystolicelastanceundervariousinotropicstatesinswine AT tlapinskas cardiovascularmagneticresonancederivedleftventricularmechanicsstraincardiacpowerandendsystolicelastanceundervariousinotropicstatesinswine AT cstehning cardiovascularmagneticresonancederivedleftventricularmechanicsstraincardiacpowerandendsystolicelastanceundervariousinotropicstatesinswine AT bschnackenburg cardiovascularmagneticresonancederivedleftventricularmechanicsstraincardiacpowerandendsystolicelastanceundervariousinotropicstatesinswine AT fplomuzio cardiovascularmagneticresonancederivedleftventricularmechanicsstraincardiacpowerandendsystolicelastanceundervariousinotropicstatesinswine AT lfassina cardiovascularmagneticresonancederivedleftventricularmechanicsstraincardiacpowerandendsystolicelastanceundervariousinotropicstatesinswine AT bpieske cardiovascularmagneticresonancederivedleftventricularmechanicsstraincardiacpowerandendsystolicelastanceundervariousinotropicstatesinswine AT enagel cardiovascularmagneticresonancederivedleftventricularmechanicsstraincardiacpowerandendsystolicelastanceundervariousinotropicstatesinswine AT hpost cardiovascularmagneticresonancederivedleftventricularmechanicsstraincardiacpowerandendsystolicelastanceundervariousinotropicstatesinswine AT skelle cardiovascularmagneticresonancederivedleftventricularmechanicsstraincardiacpowerandendsystolicelastanceundervariousinotropicstatesinswine AT aalogna cardiovascularmagneticresonancederivedleftventricularmechanicsstraincardiacpowerandendsystolicelastanceundervariousinotropicstatesinswine |