Facilitative lysosomal transport of bile acids alleviates ER stress in mouse hematopoietic precursors
Mutations in ENT3, encoded by SLC29A3, result in anaemia and erythroid hypoplasia, suggesting roles in erythropoiesis. Here the authors show that ENT3 acts as a lysosomal bile acid transporter, and mutation compromises taurine conjugated bile acid transport in erythroid progenitors leading to ER str...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-21451-6 |
| _version_ | 1818913439950569472 |
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| author | Avinash K. Persaud Sreenath Nair Md Fazlur Rahman Radhika Raj Brenna Weadick Debasis Nayak Craig McElroy Muruganandan Shanmugam Sue Knoblaugh Xiaolin Cheng Rajgopal Govindarajan |
| author_facet | Avinash K. Persaud Sreenath Nair Md Fazlur Rahman Radhika Raj Brenna Weadick Debasis Nayak Craig McElroy Muruganandan Shanmugam Sue Knoblaugh Xiaolin Cheng Rajgopal Govindarajan |
| author_sort | Avinash K. Persaud |
| collection | DOAJ |
| description | Mutations in ENT3, encoded by SLC29A3, result in anaemia and erythroid hypoplasia, suggesting roles in erythropoiesis. Here the authors show that ENT3 acts as a lysosomal bile acid transporter, and mutation compromises taurine conjugated bile acid transport in erythroid progenitors leading to ER stress, and anaemia. |
| first_indexed | 2024-12-19T23:30:31Z |
| format | Article |
| id | doaj.art-087a41082d3d4e2c8dbfb1af03cf1a8b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T23:30:31Z |
| publishDate | 2021-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-087a41082d3d4e2c8dbfb1af03cf1a8b2022-12-21T20:01:45ZengNature PortfolioNature Communications2041-17232021-02-0112111810.1038/s41467-021-21451-6Facilitative lysosomal transport of bile acids alleviates ER stress in mouse hematopoietic precursorsAvinash K. Persaud0Sreenath Nair1Md Fazlur Rahman2Radhika Raj3Brenna Weadick4Debasis Nayak5Craig McElroy6Muruganandan Shanmugam7Sue Knoblaugh8Xiaolin Cheng9Rajgopal Govindarajan10Division of Pharmaceutics & Pharmacology, College of Pharmacy, Ohio State UniversityDivision of Pharmaceutics & Pharmacology, College of Pharmacy, Ohio State UniversityDivision of Pharmaceutics & Pharmacology, College of Pharmacy, Ohio State UniversityDivision of Pharmaceutics & Pharmacology, College of Pharmacy, Ohio State UniversityDivision of Pharmaceutics & Pharmacology, College of Pharmacy, Ohio State UniversityDivision of Pharmaceutics & Pharmacology, College of Pharmacy, Ohio State UniversityDivision of Pharmaceutics & Pharmacology, College of Pharmacy, Ohio State UniversityDivision of Pharmaceutics & Pharmacology, College of Pharmacy, Ohio State UniversityDepatment of Veterinary Biosciences, College of Veterinary Medicine, Ohio State UniversityDivision of Medicinal Chemistry & Pharmacognosy, College of Pharmacy, Ohio State UniversityDivision of Pharmaceutics & Pharmacology, College of Pharmacy, Ohio State UniversityMutations in ENT3, encoded by SLC29A3, result in anaemia and erythroid hypoplasia, suggesting roles in erythropoiesis. Here the authors show that ENT3 acts as a lysosomal bile acid transporter, and mutation compromises taurine conjugated bile acid transport in erythroid progenitors leading to ER stress, and anaemia.https://doi.org/10.1038/s41467-021-21451-6 |
| spellingShingle | Avinash K. Persaud Sreenath Nair Md Fazlur Rahman Radhika Raj Brenna Weadick Debasis Nayak Craig McElroy Muruganandan Shanmugam Sue Knoblaugh Xiaolin Cheng Rajgopal Govindarajan Facilitative lysosomal transport of bile acids alleviates ER stress in mouse hematopoietic precursors Nature Communications |
| title | Facilitative lysosomal transport of bile acids alleviates ER stress in mouse hematopoietic precursors |
| title_full | Facilitative lysosomal transport of bile acids alleviates ER stress in mouse hematopoietic precursors |
| title_fullStr | Facilitative lysosomal transport of bile acids alleviates ER stress in mouse hematopoietic precursors |
| title_full_unstemmed | Facilitative lysosomal transport of bile acids alleviates ER stress in mouse hematopoietic precursors |
| title_short | Facilitative lysosomal transport of bile acids alleviates ER stress in mouse hematopoietic precursors |
| title_sort | facilitative lysosomal transport of bile acids alleviates er stress in mouse hematopoietic precursors |
| url | https://doi.org/10.1038/s41467-021-21451-6 |
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