Evaluation of K-ras and p53 expression in pancreatic adenocarcinoma using the cancer genome atlas.
Genetic alterations in K-ras and p53 are thought to be critical in pancreatic cancer development and progression. However, K-ras and p53 expression in pancreatic adenocarcinoma have not been systematically examined in The Cancer Genome Atlas (TCGA) Data Portal. Information regarding K-ras and p53 al...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5526503?pdf=render |
| _version_ | 1811197298591399936 |
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| author | Liming Lu Jingchun Zeng |
| author_facet | Liming Lu Jingchun Zeng |
| author_sort | Liming Lu |
| collection | DOAJ |
| description | Genetic alterations in K-ras and p53 are thought to be critical in pancreatic cancer development and progression. However, K-ras and p53 expression in pancreatic adenocarcinoma have not been systematically examined in The Cancer Genome Atlas (TCGA) Data Portal. Information regarding K-ras and p53 alterations, mRNA expression data, and protein/protein phosphorylation abundance was retrieved from The Cancer Genome Atlas (TCGA) databases, and analyses were performed by the cBioPortal for Cancer Genomics. The mutual exclusivity analysis showed that events in K-ras and p53 were likely to co-occur in pancreatic adenocarcinoma (Log odds ratio = 1.599, P = 0.006). The graphical summary of the mutations showed that there were hotspots for protein activation. In the network analysis, no solid association between K-ras and p53 was observed in pancreatic adenocarcinoma. In the survival analysis, neither K-ras nor p53 were associated with both survival events. As in the data mining study in the TCGA databases, our study provides a new perspective to understand the genetic features of K-ras and p53 in pancreatic adenocarcinoma. |
| first_indexed | 2024-04-12T01:12:52Z |
| format | Article |
| id | doaj.art-087a7f89ffec455191c5fe373d45fe44 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T01:12:52Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-087a7f89ffec455191c5fe373d45fe442022-12-22T03:54:03ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01127e018153210.1371/journal.pone.0181532Evaluation of K-ras and p53 expression in pancreatic adenocarcinoma using the cancer genome atlas.Liming LuJingchun ZengGenetic alterations in K-ras and p53 are thought to be critical in pancreatic cancer development and progression. However, K-ras and p53 expression in pancreatic adenocarcinoma have not been systematically examined in The Cancer Genome Atlas (TCGA) Data Portal. Information regarding K-ras and p53 alterations, mRNA expression data, and protein/protein phosphorylation abundance was retrieved from The Cancer Genome Atlas (TCGA) databases, and analyses were performed by the cBioPortal for Cancer Genomics. The mutual exclusivity analysis showed that events in K-ras and p53 were likely to co-occur in pancreatic adenocarcinoma (Log odds ratio = 1.599, P = 0.006). The graphical summary of the mutations showed that there were hotspots for protein activation. In the network analysis, no solid association between K-ras and p53 was observed in pancreatic adenocarcinoma. In the survival analysis, neither K-ras nor p53 were associated with both survival events. As in the data mining study in the TCGA databases, our study provides a new perspective to understand the genetic features of K-ras and p53 in pancreatic adenocarcinoma.http://europepmc.org/articles/PMC5526503?pdf=render |
| spellingShingle | Liming Lu Jingchun Zeng Evaluation of K-ras and p53 expression in pancreatic adenocarcinoma using the cancer genome atlas. PLoS ONE |
| title | Evaluation of K-ras and p53 expression in pancreatic adenocarcinoma using the cancer genome atlas. |
| title_full | Evaluation of K-ras and p53 expression in pancreatic adenocarcinoma using the cancer genome atlas. |
| title_fullStr | Evaluation of K-ras and p53 expression in pancreatic adenocarcinoma using the cancer genome atlas. |
| title_full_unstemmed | Evaluation of K-ras and p53 expression in pancreatic adenocarcinoma using the cancer genome atlas. |
| title_short | Evaluation of K-ras and p53 expression in pancreatic adenocarcinoma using the cancer genome atlas. |
| title_sort | evaluation of k ras and p53 expression in pancreatic adenocarcinoma using the cancer genome atlas |
| url | http://europepmc.org/articles/PMC5526503?pdf=render |
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