Neuropilin-1 Associated Molecules in the Blood Distinguish Poor Prognosis Breast Cancer: A Cross-Sectional Study
Abstract Circulating plasma and peripheral blood mononuclear (PBMCs) cells provide an informative snapshot of the systemic physiological state. Moreover, they provide a non-invasively accessible compartment to identify biomarkers for personalized medicine in advanced breast cancer. The role of Neuro...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-03280-0 |
| _version_ | 1818405514932912128 |
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| author | Adviti Naik Noura Al-Zeheimi Charles Saki Bakheit Marwa Al Riyami Adil Al Jarrah Mansour S. Al Moundhri Zamzam Al Habsi Maysoon Basheer Sirin A. Adham |
| author_facet | Adviti Naik Noura Al-Zeheimi Charles Saki Bakheit Marwa Al Riyami Adil Al Jarrah Mansour S. Al Moundhri Zamzam Al Habsi Maysoon Basheer Sirin A. Adham |
| author_sort | Adviti Naik |
| collection | DOAJ |
| description | Abstract Circulating plasma and peripheral blood mononuclear (PBMCs) cells provide an informative snapshot of the systemic physiological state. Moreover, they provide a non-invasively accessible compartment to identify biomarkers for personalized medicine in advanced breast cancer. The role of Neuropilin-1 (NRP-1) and its interacting molecules in breast tumor tissue was correlated with cancer progression; however, the clinical impact of their systemic levels was not extensively evaluated. In this cross-sectional study, we found that circulating and tumor tissue expression of NRP-1 and circulating placental growth factor (PlGF) increase in advanced nodal and metastatic breast cancer compared with locally advanced disease. Tumor tissue expression of NRP-1 and PlGF is also upregulated in triple negative breast cancer (TNBC) compared to other subtypes. Conversely, in PBMCs, NRP-1 and its interacting molecules SEMA4A and SNAI1 are significantly downregulated in breast cancer patients compared to healthy controls, indicating a protective role. Moreover, we report differential PBMC expression profiles that correlate inversely with disease stage (SEMA4A, SNAI1, PLXNA1 and VEGFR3) and can differentiate between the TNBC and non-TNBC tumor subtypes (VEGFR3 and PLXNA1). This work supports the importance of NRP-1-associated molecules in circulation to characterize poor prognosis breast cancer and emphasizes on their role as favorable drug targets. |
| first_indexed | 2024-12-14T08:57:16Z |
| format | Article |
| id | doaj.art-087d3ded70bd4d49b2929792f742aed6 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T08:57:16Z |
| publishDate | 2017-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-087d3ded70bd4d49b2929792f742aed62022-12-21T23:08:54ZengNature PortfolioScientific Reports2045-23222017-06-017111410.1038/s41598-017-03280-0Neuropilin-1 Associated Molecules in the Blood Distinguish Poor Prognosis Breast Cancer: A Cross-Sectional StudyAdviti Naik0Noura Al-Zeheimi1Charles Saki Bakheit2Marwa Al Riyami3Adil Al Jarrah4Mansour S. Al Moundhri5Zamzam Al Habsi6Maysoon Basheer7Sirin A. Adham8Department of Biology, College of Science, Sultan Qaboos UniversityDepartment of Biology, College of Science, Sultan Qaboos UniversityDepartment of Mathematics and Statistics, Sultan Qaboos UniversityDepartment of Pathology, College of Medicine, Sultan Qaboos UniversityDepartment of Surgery, Sultan Qaboos University HospitalDepartment of Medicine, College of Medicine, Sultan Qaboos UniversityDepartment of Surgery, Sultan Qaboos University HospitalDepartment of Biology, College of Science, Sultan Qaboos UniversityDepartment of Biology, College of Science, Sultan Qaboos UniversityAbstract Circulating plasma and peripheral blood mononuclear (PBMCs) cells provide an informative snapshot of the systemic physiological state. Moreover, they provide a non-invasively accessible compartment to identify biomarkers for personalized medicine in advanced breast cancer. The role of Neuropilin-1 (NRP-1) and its interacting molecules in breast tumor tissue was correlated with cancer progression; however, the clinical impact of their systemic levels was not extensively evaluated. In this cross-sectional study, we found that circulating and tumor tissue expression of NRP-1 and circulating placental growth factor (PlGF) increase in advanced nodal and metastatic breast cancer compared with locally advanced disease. Tumor tissue expression of NRP-1 and PlGF is also upregulated in triple negative breast cancer (TNBC) compared to other subtypes. Conversely, in PBMCs, NRP-1 and its interacting molecules SEMA4A and SNAI1 are significantly downregulated in breast cancer patients compared to healthy controls, indicating a protective role. Moreover, we report differential PBMC expression profiles that correlate inversely with disease stage (SEMA4A, SNAI1, PLXNA1 and VEGFR3) and can differentiate between the TNBC and non-TNBC tumor subtypes (VEGFR3 and PLXNA1). This work supports the importance of NRP-1-associated molecules in circulation to characterize poor prognosis breast cancer and emphasizes on their role as favorable drug targets.https://doi.org/10.1038/s41598-017-03280-0 |
| spellingShingle | Adviti Naik Noura Al-Zeheimi Charles Saki Bakheit Marwa Al Riyami Adil Al Jarrah Mansour S. Al Moundhri Zamzam Al Habsi Maysoon Basheer Sirin A. Adham Neuropilin-1 Associated Molecules in the Blood Distinguish Poor Prognosis Breast Cancer: A Cross-Sectional Study Scientific Reports |
| title | Neuropilin-1 Associated Molecules in the Blood Distinguish Poor Prognosis Breast Cancer: A Cross-Sectional Study |
| title_full | Neuropilin-1 Associated Molecules in the Blood Distinguish Poor Prognosis Breast Cancer: A Cross-Sectional Study |
| title_fullStr | Neuropilin-1 Associated Molecules in the Blood Distinguish Poor Prognosis Breast Cancer: A Cross-Sectional Study |
| title_full_unstemmed | Neuropilin-1 Associated Molecules in the Blood Distinguish Poor Prognosis Breast Cancer: A Cross-Sectional Study |
| title_short | Neuropilin-1 Associated Molecules in the Blood Distinguish Poor Prognosis Breast Cancer: A Cross-Sectional Study |
| title_sort | neuropilin 1 associated molecules in the blood distinguish poor prognosis breast cancer a cross sectional study |
| url | https://doi.org/10.1038/s41598-017-03280-0 |
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