Ipriflavone Suppresses Growth of Esophageal Squamous Cell Carcinoma Through Inhibiting mTOR In Vitro and In Vivo

Ipriflavone Suppresses Growth of Esophageal Squamous Cell Carcinoma Through Inhibiting mTOR In Vitro and In Vivo

Ipriflavone, a synthetic isoflavone that inhibits osteoclastic bone resorption, has been used clinically for the treatment of osteoporosis. However, the anticancer activity of Ipriflavone and its molecular mechanisms in the context of esophageal squamous cell carcinoma (ESCC) have not been investiga...

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Bibliographic Details
Main Authors: Xiaodan Shi, Yuanyuan Zhang, Xiaomeng Xie, Mengjun Pang, Kyle Laster, Jian Li, Xinli Ma, Kangdong Liu, Zigang Dong, Dong Joon Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Oncology
Subjects:
patient-derived xenograft (PDX)
ESCC
P70S6K
mTOR
Ipriflavone
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.648809/full

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