Spatial memory-enhancing effects and antioxidant activities of leaf and stem bark methanol extracts of Prunus africana in scopolamine-treated mice
Introduction: Conventional medicines for Alzheimer’s disease (AD) have little efficacy and are linked to several severe effects, necessitating alternative therapy. The current study investigated the memory-enhancing effects and antioxidant activities of stem bark and leaf MeOH extracts of Prunus afr...
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| Format: | Article |
| Language: | English |
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Shahrekord University of Medical Sciences
2023-04-01
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| Series: | Journal of HerbMed Pharmacology |
| Subjects: | |
| Online Access: | http://herbmedpharmacol.com/PDF/jhp-12-315.pdf |
| _version_ | 1797839581331062784 |
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| author | David Nyaga Ngai Cromwell Mwiti Kibiti Mathew Piero Ngugi |
| author_facet | David Nyaga Ngai Cromwell Mwiti Kibiti Mathew Piero Ngugi |
| author_sort | David Nyaga Ngai |
| collection | DOAJ |
| description | Introduction: Conventional medicines for Alzheimer’s disease (AD) have little efficacy and are linked to several severe effects, necessitating alternative therapy. The current study investigated the memory-enhancing effects and antioxidant activities of stem bark and leaf MeOH extracts of Prunus africana in scopolamine-induced amnesic mice. Several inclusions build up in brain tissue during AD progression and the brain clears them oxidatively. This makes the antioxidant activity a vital requirement for plant extracts that are used with great success to manage AD. Methods: In this study, for each plant extract, thirty Swiss albino mice were randomly assigned to six groups; extract-treated, reference drug control, normal control, and negative control groups. The mice were then subjected to the Morris water maze task for four consecutive days, euthanized and their whole brains were assessed for antioxidant activities. Results: The studied extracts significantly (P < 0.01) reduced escape latencies of experimental mice in a dose-related manner, depicting their considerable memory-enhancing effects. The extracts also displayed significant (P < 0.01) enzymatic and non-enzymatic antioxidant activities. Conclusion: The leaf and stem bark MeOH extracts of P. africana possess phytocompounds with spatial memory-enhancing effects and antioxidant activities. |
| first_indexed | 2024-04-09T16:00:15Z |
| format | Article |
| id | doaj.art-087eda9b6f3f45608482ac40a8ae1dde |
| institution | Directory Open Access Journal |
| issn | 2345-5004 |
| language | English |
| last_indexed | 2024-04-09T16:00:15Z |
| publishDate | 2023-04-01 |
| publisher | Shahrekord University of Medical Sciences |
| record_format | Article |
| series | Journal of HerbMed Pharmacology |
| spelling | doaj.art-087eda9b6f3f45608482ac40a8ae1dde2023-04-25T12:41:55ZengShahrekord University of Medical SciencesJournal of HerbMed Pharmacology2345-50042023-04-0112231532610.34172/jhp.2023.33jhp-44760Spatial memory-enhancing effects and antioxidant activities of leaf and stem bark methanol extracts of Prunus africana in scopolamine-treated miceDavid Nyaga Ngai0Cromwell Mwiti Kibiti1Mathew Piero Ngugi2Department of Biochemistry, Microbiology and Biotechnology, School of Pure and Applied Sciences, Kenyatta University, P.O. Box 43844-00100, Nairobi, KenyaDepartment of Pure and Applied Sciences, Technical University of Mombasa, P.O. Box 90420-80100, Mombasa, KenyaDepartment of Biochemistry, Microbiology and Biotechnology, School of Pure and Applied Sciences, Kenyatta University, P.O. Box 43844-00100, Nairobi, KenyaIntroduction: Conventional medicines for Alzheimer’s disease (AD) have little efficacy and are linked to several severe effects, necessitating alternative therapy. The current study investigated the memory-enhancing effects and antioxidant activities of stem bark and leaf MeOH extracts of Prunus africana in scopolamine-induced amnesic mice. Several inclusions build up in brain tissue during AD progression and the brain clears them oxidatively. This makes the antioxidant activity a vital requirement for plant extracts that are used with great success to manage AD. Methods: In this study, for each plant extract, thirty Swiss albino mice were randomly assigned to six groups; extract-treated, reference drug control, normal control, and negative control groups. The mice were then subjected to the Morris water maze task for four consecutive days, euthanized and their whole brains were assessed for antioxidant activities. Results: The studied extracts significantly (P < 0.01) reduced escape latencies of experimental mice in a dose-related manner, depicting their considerable memory-enhancing effects. The extracts also displayed significant (P < 0.01) enzymatic and non-enzymatic antioxidant activities. Conclusion: The leaf and stem bark MeOH extracts of P. africana possess phytocompounds with spatial memory-enhancing effects and antioxidant activities.http://herbmedpharmacol.com/PDF/jhp-12-315.pdfalzheimer’s diseasedonepeziloxidative stressphytochemistrymorris water maze |
| spellingShingle | David Nyaga Ngai Cromwell Mwiti Kibiti Mathew Piero Ngugi Spatial memory-enhancing effects and antioxidant activities of leaf and stem bark methanol extracts of Prunus africana in scopolamine-treated mice Journal of HerbMed Pharmacology alzheimer’s disease donepezil oxidative stress phytochemistry morris water maze |
| title | Spatial memory-enhancing effects and antioxidant activities of leaf and stem bark methanol extracts of Prunus africana in scopolamine-treated mice |
| title_full | Spatial memory-enhancing effects and antioxidant activities of leaf and stem bark methanol extracts of Prunus africana in scopolamine-treated mice |
| title_fullStr | Spatial memory-enhancing effects and antioxidant activities of leaf and stem bark methanol extracts of Prunus africana in scopolamine-treated mice |
| title_full_unstemmed | Spatial memory-enhancing effects and antioxidant activities of leaf and stem bark methanol extracts of Prunus africana in scopolamine-treated mice |
| title_short | Spatial memory-enhancing effects and antioxidant activities of leaf and stem bark methanol extracts of Prunus africana in scopolamine-treated mice |
| title_sort | spatial memory enhancing effects and antioxidant activities of leaf and stem bark methanol extracts of prunus africana in scopolamine treated mice |
| topic | alzheimer’s disease donepezil oxidative stress phytochemistry morris water maze |
| url | http://herbmedpharmacol.com/PDF/jhp-12-315.pdf |
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