The Metabolism of Separase Inhibitor Sepin-1 in Human, Mouse, and Rat Liver Microsomes

The Metabolism of Separase Inhibitor Sepin-1 in Human, Mouse, and Rat Liver Microsomes

Separase, a known oncogene, is widely overexpressed in numerous human tumors of breast, bone, brain, blood, and prostate. Separase is an emerging target for cancer therapy, and separase enzymatic inhibitors such as sepin-1 are currently being developed to treat separase-overexpressed tumors. Drug me...

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Bibliographic Details
Main Authors:	Feng Li, Nenggang Zhang, Siddharth Gorantla, Scott R. Gilbertson, Debananda Pati
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-05-01
Series:	Frontiers in Pharmacology
Subjects:	separase inhibitor liver microsomes sepin-1 metabolism CYP450 inhibition metabolite identification
Online Access:	http://journal.frontiersin.org/article/10.3389/fphar.2018.00313/full

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