Induction of Lysosomal Membrane Permeabilization Is a Major Event of FTY720-Mediated Non-Apoptotic Cell Death in Human Glioma Cells

Induction of Lysosomal Membrane Permeabilization Is a Major Event of FTY720-Mediated Non-Apoptotic Cell Death in Human Glioma Cells

FTY720, a sphingosine-1-phosphate (S1P) receptor modulator, is a synthetic compound produced by the modification of a metabolite from <i>I. sinclairii</i>. Here, we found that FTY720 induced non-apoptotic cell death in human glioma cells (U251MG, U87MG, and U118MG). FTY720 (10 µM) dramat...

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Bibliographic Details
Main Authors: Kyoung-jin Min, Taeg Kyu Kwon
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cancers
Subjects:
FTY720
non-apoptotic cell death
LMP
cathepsins
glioma
Online Access:https://www.mdpi.com/2072-6694/12/11/3388

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