Variations in the prevalence of childhood asthma and wheeze in MeDALL cohorts in Europe
While there is evidence for variations in prevalence rates of childhood wheeze and asthma between countries, longitudinal, individual-level data are needed to understand these differences. The aim of this study was to examine variations in prevalence rates of childhood asthma, wheeze and wheeze with...
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| Format: | Article |
| Language: | English |
| Published: |
European Respiratory Society
2017-07-01
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| Series: | ERJ Open Research |
| Online Access: | http://openres.ersjournals.com/content/3/3/00150-2016.full |
| _version_ | 1828180916416020480 |
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| author | Eleonora P. Uphoff Philippa K. Bird Joseph Maria Antó Mikel Basterrechea Andrea von Berg Anna Bergström Jean Bousquet Leda Chatzi Maria Pia Fantini Amparo Ferrero Ulrike Gehring Davide Gori Joachim Heinrich Thomas Keil Inger Kull Susanne Lau Dieter Maier Isabelle Momas Silvia Narduzzi Daniela Porta Fanny Ranciere Theano Roumeliotaki Tamara Schikowski Henriette A. Smit Marie Standl Jordi Sunyer John Wright |
| author_facet | Eleonora P. Uphoff Philippa K. Bird Joseph Maria Antó Mikel Basterrechea Andrea von Berg Anna Bergström Jean Bousquet Leda Chatzi Maria Pia Fantini Amparo Ferrero Ulrike Gehring Davide Gori Joachim Heinrich Thomas Keil Inger Kull Susanne Lau Dieter Maier Isabelle Momas Silvia Narduzzi Daniela Porta Fanny Ranciere Theano Roumeliotaki Tamara Schikowski Henriette A. Smit Marie Standl Jordi Sunyer John Wright |
| author_sort | Eleonora P. Uphoff |
| collection | DOAJ |
| description | While there is evidence for variations in prevalence rates of childhood wheeze and asthma between countries, longitudinal, individual-level data are needed to understand these differences. The aim of this study was to examine variations in prevalence rates of childhood asthma, wheeze and wheeze with asthma in Europe. We analysed datasets from 10 MeDALL (Mechanisms of the Development of ALLergy) cohorts in eight countries, representing 26 663 children, to calculate prevalence rates of wheeze and asthma by child age and wheeze with asthma at age 4 years. Harmonised variables included outcomes parent-reported wheeze and parent-reported doctor-diagnosed asthma, and covariates maternal education, parental smoking, pets, parental asthma, doctor-diagnosed allergic rhinitis, doctor-diagnosed eczema and wheeze severity. At age 4 years, asthma prevalence varied from 1.72% in Germany to 13.48% in England and the prevalence of wheeze varied from 9.82% in Greece to 55.37% in Spain. Adjusted estimates of the proportion of 4-year-old children with wheeze diagnosed with asthma remained highest in England (38.14%, 95% CI 31.38–44.90%) and lowest in Spain (15.94%, 95% CI 6.16–25.71%). The large differences in prevalence rates of asthma, wheeze and wheeze with asthma at age 4 years between European cohorts may indicate that childhood asthma is more readily diagnosed in some countries while going unrecognised elsewhere. |
| first_indexed | 2024-04-12T05:53:31Z |
| format | Article |
| id | doaj.art-08822c59224b40ac9c8711498e71f1ec |
| institution | Directory Open Access Journal |
| issn | 2312-0541 |
| language | English |
| last_indexed | 2024-04-12T05:53:31Z |
| publishDate | 2017-07-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | ERJ Open Research |
| spelling | doaj.art-08822c59224b40ac9c8711498e71f1ec2022-12-22T03:45:13ZengEuropean Respiratory SocietyERJ Open Research2312-05412017-07-013310.1183/23120541.00150-201600150-2016Variations in the prevalence of childhood asthma and wheeze in MeDALL cohorts in EuropeEleonora P. Uphoff0Philippa K. Bird1Joseph Maria Antó2Mikel Basterrechea3Andrea von Berg4Anna Bergström5Jean Bousquet6Leda Chatzi7Maria Pia Fantini8Amparo Ferrero9Ulrike Gehring10Davide Gori11Joachim Heinrich12Thomas Keil13Inger Kull14Susanne Lau15Dieter Maier16Isabelle Momas17Silvia Narduzzi18Daniela Porta19Fanny Ranciere20Theano Roumeliotaki21Tamara Schikowski22Henriette A. Smit23Marie Standl24Jordi Sunyer25John Wright26 Bradford Institute for Health Research, Bradford, UK Bradford Institute for Health Research, Bradford, UK Insituto de Salud Global Barcelona, Barcelona, Spain CIBER Epidemiología y Salud Pública, Madrid, Spain Dept of Pediatrics, Marien Hospital Wesel, Wesel, Germany Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden Centre Hôpital Universitaire de Montpellier, Montpellier, France Dept of Social Medicine, University of Crete, Heraklion, Greece Dipartimento di Scienze Biomediche e Neuromotorie, Universita degli Studi di Bologna, Bologna, Italy CIBER Epidemiología y Salud Pública, Madrid, Spain Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands Dipartimento di Scienze Biomediche e Neuromotorie, Universita degli Studi di Bologna, Bologna, Italy Institute of Epidemiology, Helmholtz Zentrum München, Munich, Germany Social Medicine, Epidemiology and Health Economics, Charité Medical University, Berlin, Germany Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden Pediatric Pneumology and Immunology, Charité Medical University, Berlin, Germany Biomax Informatics AG, Planegg, Germany Université Paris Descartes, Paris, France Dipartimento di Epidemiologia del SSR del Lazio, Rome, Italy Dipartimento di Epidemiologia del SSR del Lazio, Rome, Italy Université Paris Descartes, Paris, France Dept of Social Medicine, University of Crete, Heraklion, Greece Leibniz-Institut für umweltmedizinische Forschung, Heinrich Heine Universitat, Düsseldorf, Germany Julius Center for Health Sciences and Primary Care, Public Health, Health Technology Assessment, Medical Humanities, University Medical Center Utrecht, Utrecht, The Netherlands Institute of Epidemiology, Helmholtz Zentrum München, Munich, Germany Insituto de Salud Global Barcelona, Barcelona, Spain Bradford Institute for Health Research, Bradford, UK While there is evidence for variations in prevalence rates of childhood wheeze and asthma between countries, longitudinal, individual-level data are needed to understand these differences. The aim of this study was to examine variations in prevalence rates of childhood asthma, wheeze and wheeze with asthma in Europe. We analysed datasets from 10 MeDALL (Mechanisms of the Development of ALLergy) cohorts in eight countries, representing 26 663 children, to calculate prevalence rates of wheeze and asthma by child age and wheeze with asthma at age 4 years. Harmonised variables included outcomes parent-reported wheeze and parent-reported doctor-diagnosed asthma, and covariates maternal education, parental smoking, pets, parental asthma, doctor-diagnosed allergic rhinitis, doctor-diagnosed eczema and wheeze severity. At age 4 years, asthma prevalence varied from 1.72% in Germany to 13.48% in England and the prevalence of wheeze varied from 9.82% in Greece to 55.37% in Spain. Adjusted estimates of the proportion of 4-year-old children with wheeze diagnosed with asthma remained highest in England (38.14%, 95% CI 31.38–44.90%) and lowest in Spain (15.94%, 95% CI 6.16–25.71%). The large differences in prevalence rates of asthma, wheeze and wheeze with asthma at age 4 years between European cohorts may indicate that childhood asthma is more readily diagnosed in some countries while going unrecognised elsewhere.http://openres.ersjournals.com/content/3/3/00150-2016.full |
| spellingShingle | Eleonora P. Uphoff Philippa K. Bird Joseph Maria Antó Mikel Basterrechea Andrea von Berg Anna Bergström Jean Bousquet Leda Chatzi Maria Pia Fantini Amparo Ferrero Ulrike Gehring Davide Gori Joachim Heinrich Thomas Keil Inger Kull Susanne Lau Dieter Maier Isabelle Momas Silvia Narduzzi Daniela Porta Fanny Ranciere Theano Roumeliotaki Tamara Schikowski Henriette A. Smit Marie Standl Jordi Sunyer John Wright Variations in the prevalence of childhood asthma and wheeze in MeDALL cohorts in Europe ERJ Open Research |
| title | Variations in the prevalence of childhood asthma and wheeze in MeDALL cohorts in Europe |
| title_full | Variations in the prevalence of childhood asthma and wheeze in MeDALL cohorts in Europe |
| title_fullStr | Variations in the prevalence of childhood asthma and wheeze in MeDALL cohorts in Europe |
| title_full_unstemmed | Variations in the prevalence of childhood asthma and wheeze in MeDALL cohorts in Europe |
| title_short | Variations in the prevalence of childhood asthma and wheeze in MeDALL cohorts in Europe |
| title_sort | variations in the prevalence of childhood asthma and wheeze in medall cohorts in europe |
| url | http://openres.ersjournals.com/content/3/3/00150-2016.full |
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