Oxidative stress in COPD, pathogenesis and therapeutic views
Chronic obstructive pulmonary disease (COPD), characterised by partially reversible contracture of small respiratory airways seems to be among leading causes of death in the world. COPD is characterized by inflammation, protease/antiprotease imbalance, genetic variability and oxidative stress. The l...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2014-08-01
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| Series: | Reviews in Clinical Medicine |
| Subjects: | |
| Online Access: | https://rcm.mums.ac.ir/article_2795_2eb2c3ba25562d1d157704dfef9d8c1d.pdf |
| _version_ | 1797976050620170240 |
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| author | Fariba Rezaeetalab Daryush Hamidi alamdari Asghar Dalili |
| author_facet | Fariba Rezaeetalab Daryush Hamidi alamdari Asghar Dalili |
| author_sort | Fariba Rezaeetalab |
| collection | DOAJ |
| description | Chronic obstructive pulmonary disease (COPD), characterised by partially reversible contracture of small respiratory airways seems to be among leading causes of death in the world. COPD is characterized by inflammation, protease/antiprotease imbalance, genetic variability and oxidative stress. The latter refers to a condition in which oxidative agents overcome against antioxidants. In this review literature, the consequences of oxidative stress in COPD, such as systemic and pulmonary neutrophil influx, hypersecretion, dual and reciprocal effects with inflammatory contributors and systemic manifestations are discussed. In addition, a review of oxidative stress biomarkers as well as therapeutic strategies based on recent researches for antioxidant supplementation therapy is provided. |
| first_indexed | 2024-04-11T04:45:10Z |
| format | Article |
| id | doaj.art-088288d126094390ace1a562a73e4a02 |
| institution | Directory Open Access Journal |
| issn | 2345-6256 2345-6892 |
| language | English |
| last_indexed | 2024-04-11T04:45:10Z |
| publishDate | 2014-08-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Reviews in Clinical Medicine |
| spelling | doaj.art-088288d126094390ace1a562a73e4a022022-12-27T13:13:36ZengMashhad University of Medical SciencesReviews in Clinical Medicine2345-62562345-68922014-08-011311512410.17463/RCM.2014.03.0052795Oxidative stress in COPD, pathogenesis and therapeutic viewsFariba Rezaeetalab0Daryush Hamidi alamdari1Asghar Dalili2COPD Research Center, Department of Internal Medicine, Imam-Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Internal Medicine, Imam-Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranChronic obstructive pulmonary disease (COPD), characterised by partially reversible contracture of small respiratory airways seems to be among leading causes of death in the world. COPD is characterized by inflammation, protease/antiprotease imbalance, genetic variability and oxidative stress. The latter refers to a condition in which oxidative agents overcome against antioxidants. In this review literature, the consequences of oxidative stress in COPD, such as systemic and pulmonary neutrophil influx, hypersecretion, dual and reciprocal effects with inflammatory contributors and systemic manifestations are discussed. In addition, a review of oxidative stress biomarkers as well as therapeutic strategies based on recent researches for antioxidant supplementation therapy is provided.https://rcm.mums.ac.ir/article_2795_2eb2c3ba25562d1d157704dfef9d8c1d.pdfchronic obstructive pulmonary disease (copd)hypersecretionoxidative stress |
| spellingShingle | Fariba Rezaeetalab Daryush Hamidi alamdari Asghar Dalili Oxidative stress in COPD, pathogenesis and therapeutic views Reviews in Clinical Medicine chronic obstructive pulmonary disease (copd) hypersecretion oxidative stress |
| title | Oxidative stress in COPD, pathogenesis and therapeutic views |
| title_full | Oxidative stress in COPD, pathogenesis and therapeutic views |
| title_fullStr | Oxidative stress in COPD, pathogenesis and therapeutic views |
| title_full_unstemmed | Oxidative stress in COPD, pathogenesis and therapeutic views |
| title_short | Oxidative stress in COPD, pathogenesis and therapeutic views |
| title_sort | oxidative stress in copd pathogenesis and therapeutic views |
| topic | chronic obstructive pulmonary disease (copd) hypersecretion oxidative stress |
| url | https://rcm.mums.ac.ir/article_2795_2eb2c3ba25562d1d157704dfef9d8c1d.pdf |
| work_keys_str_mv | AT faribarezaeetalab oxidativestressincopdpathogenesisandtherapeuticviews AT daryushhamidialamdari oxidativestressincopdpathogenesisandtherapeuticviews AT asghardalili oxidativestressincopdpathogenesisandtherapeuticviews |