A Recombinant BCG Vaccine Is Safe and Immunogenic in Neonatal Calves and Reduces the Clinical Disease Caused by the Respiratory Syncytial Virus

A Recombinant BCG Vaccine Is Safe and Immunogenic in Neonatal Calves and Reduces the Clinical Disease Caused by the Respiratory Syncytial Virus

The human respiratory syncytial virus (hRSV) constitutes a major health burden, causing millions of hospitalizations in children under five years old worldwide due to acute lower respiratory tract infections. Despite decades of research, licensed vaccines to prevent hRSV are not available. Developme...

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Bibliographic Details
Main Authors: Fabián E. Díaz, Mariana Guerra-Maupome, Paiton O. McDonald, Daniela Rivera-Pérez, Alexis M. Kalergis, Jodi L. McGill
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
RSV
neonatal calf model
vaccines
BCG
recombinant BCG
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.664212/full

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