Spread of an Experimental <i>Salmonella</i> Derby Infection in Antibiotic-Treated or <i>Lawsonia intracellularis</i> Vaccinated Piglets
<i>Lawsonia intracellularis</i> infections are a common reason for antibiotic treatment in pig production. Experimental studies in animals naturally infected with <i>Lawsonia intracellularis</i> comparing the course of an experimental <i>Salmonella</i> infection i...
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MDPI AG
2018-11-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/8/11/206 |
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| author | Christian Visscher Jasmin Mischok Saara Sander Jutta Verspohl Eva-Ursula Peitzmeier Isabel von dem Busche Josef Kamphues |
| author_facet | Christian Visscher Jasmin Mischok Saara Sander Jutta Verspohl Eva-Ursula Peitzmeier Isabel von dem Busche Josef Kamphues |
| author_sort | Christian Visscher |
| collection | DOAJ |
| description | <i>Lawsonia intracellularis</i> infections are a common reason for antibiotic treatment in pig production. Experimental studies in animals naturally infected with <i>Lawsonia intracellularis</i> comparing the course of an experimental <i>Salmonella</i> infection in piglets previously treated with tylosin or vaccinated against <i>Lawsonia intracellularis</i> are scarce. A total of 72 seven-week-old <i>Salmonella</i>-free pigs were taken from a herd with a <i>Lawsonia intracellularis</i> history in piglet rearing. The pigs were divided into two groups with three replicates each. Animals had either been previously treated with tylosin (10 mg/kg body weight) for seven days (AB<sup>+</sup>VAC<sup>−</sup>) or had been vaccinated as suckling pigs by drenching (Enterisol<sup>®</sup>Ileitis; AB<sup>−</sup>VAC<sup>+</sup>). Two animals per replicate were primarily infected with <i>Salmonella</i> Derby (1.04 × 10<sup>8</sup> colony-forming units per animal). The detection of <i>Salmonella</i> in faeces (<i>p</i> < 0.0001, odds ratio: 3.8364) and in the ileocaecal lymph nodes (<i>p</i> = 0.0295, odds ratio: 3.5043) was significantly more frequent in AB<sup>+</sup>VAC<sup>−</sup> animals. Overall, the odds ratio for detecting <i>Salmonella</i> in any substrate or organ was significantly higher in the AB<sup>+</sup>VAC<sup>−</sup> group animals (<i>p</i> = 0.0004, odds ratio: 5.9091). Treatment with tylosin can significantly increase the spread of a <i>Salmonella</i> infection, which is not observed after early <i>Lawsonia intracellularis</i> vaccination. |
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| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-12-22T19:42:22Z |
| publishDate | 2018-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-0884114c1355490ca560cdda40398e6f2022-12-21T18:14:48ZengMDPI AGAnimals2076-26152018-11-0181120610.3390/ani8110206ani8110206Spread of an Experimental <i>Salmonella</i> Derby Infection in Antibiotic-Treated or <i>Lawsonia intracellularis</i> Vaccinated PigletsChristian Visscher0Jasmin Mischok1Saara Sander2Jutta Verspohl3Eva-Ursula Peitzmeier4Isabel von dem Busche5Josef Kamphues6Institute for Animal Nutrition, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15, D-30173 Hanover, GermanyInstitute for Animal Nutrition, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15, D-30173 Hanover, GermanyInstitute for Animal Nutrition, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15, D-30173 Hanover, GermanyInstitute for Microbiology, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15, D-30173 Hannover, GermanyTierarztpraxis Dr. Peitzmeier, Meente 24, D-32479 Hille, GermanyTierarztpraxis Dr. Peitzmeier, Meente 24, D-32479 Hille, GermanyInstitute for Animal Nutrition, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15, D-30173 Hanover, Germany<i>Lawsonia intracellularis</i> infections are a common reason for antibiotic treatment in pig production. Experimental studies in animals naturally infected with <i>Lawsonia intracellularis</i> comparing the course of an experimental <i>Salmonella</i> infection in piglets previously treated with tylosin or vaccinated against <i>Lawsonia intracellularis</i> are scarce. A total of 72 seven-week-old <i>Salmonella</i>-free pigs were taken from a herd with a <i>Lawsonia intracellularis</i> history in piglet rearing. The pigs were divided into two groups with three replicates each. Animals had either been previously treated with tylosin (10 mg/kg body weight) for seven days (AB<sup>+</sup>VAC<sup>−</sup>) or had been vaccinated as suckling pigs by drenching (Enterisol<sup>®</sup>Ileitis; AB<sup>−</sup>VAC<sup>+</sup>). Two animals per replicate were primarily infected with <i>Salmonella</i> Derby (1.04 × 10<sup>8</sup> colony-forming units per animal). The detection of <i>Salmonella</i> in faeces (<i>p</i> < 0.0001, odds ratio: 3.8364) and in the ileocaecal lymph nodes (<i>p</i> = 0.0295, odds ratio: 3.5043) was significantly more frequent in AB<sup>+</sup>VAC<sup>−</sup> animals. Overall, the odds ratio for detecting <i>Salmonella</i> in any substrate or organ was significantly higher in the AB<sup>+</sup>VAC<sup>−</sup> group animals (<i>p</i> = 0.0004, odds ratio: 5.9091). Treatment with tylosin can significantly increase the spread of a <i>Salmonella</i> infection, which is not observed after early <i>Lawsonia intracellularis</i> vaccination.https://www.mdpi.com/2076-2615/8/11/206antibioticscaecuminfectionlymph nodes<i>Lawsonia intracellularis</i><i>Salmonella</i> Derbyvaccination |
| spellingShingle | Christian Visscher Jasmin Mischok Saara Sander Jutta Verspohl Eva-Ursula Peitzmeier Isabel von dem Busche Josef Kamphues Spread of an Experimental <i>Salmonella</i> Derby Infection in Antibiotic-Treated or <i>Lawsonia intracellularis</i> Vaccinated Piglets Animals antibiotics caecum infection lymph nodes <i>Lawsonia intracellularis</i> <i>Salmonella</i> Derby vaccination |
| title | Spread of an Experimental <i>Salmonella</i> Derby Infection in Antibiotic-Treated or <i>Lawsonia intracellularis</i> Vaccinated Piglets |
| title_full | Spread of an Experimental <i>Salmonella</i> Derby Infection in Antibiotic-Treated or <i>Lawsonia intracellularis</i> Vaccinated Piglets |
| title_fullStr | Spread of an Experimental <i>Salmonella</i> Derby Infection in Antibiotic-Treated or <i>Lawsonia intracellularis</i> Vaccinated Piglets |
| title_full_unstemmed | Spread of an Experimental <i>Salmonella</i> Derby Infection in Antibiotic-Treated or <i>Lawsonia intracellularis</i> Vaccinated Piglets |
| title_short | Spread of an Experimental <i>Salmonella</i> Derby Infection in Antibiotic-Treated or <i>Lawsonia intracellularis</i> Vaccinated Piglets |
| title_sort | spread of an experimental i salmonella i derby infection in antibiotic treated or i lawsonia intracellularis i vaccinated piglets |
| topic | antibiotics caecum infection lymph nodes <i>Lawsonia intracellularis</i> <i>Salmonella</i> Derby vaccination |
| url | https://www.mdpi.com/2076-2615/8/11/206 |
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