Relationship between Habitual Intake of Vitamins and New-Onset Prediabetes/Diabetes after Acute Pancreatitis
Vitamins have many established roles in human health. However, the role of habitual dietary intake of vitamins in glucose homeostasis in individuals after acute pancreatitis (AP) is yet to be elucidated. The aim was to investigate the associations between habitual intake of fat- and water-soluble vi...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-04-01
|
| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/14/7/1480 |
| _version_ | 1797438092565544960 |
|---|---|
| author | Claire F. Norbitt Wandia Kimita Sakina H. Bharmal Juyeon Ko Maxim S. Petrov |
| author_facet | Claire F. Norbitt Wandia Kimita Sakina H. Bharmal Juyeon Ko Maxim S. Petrov |
| author_sort | Claire F. Norbitt |
| collection | DOAJ |
| description | Vitamins have many established roles in human health. However, the role of habitual dietary intake of vitamins in glucose homeostasis in individuals after acute pancreatitis (AP) is yet to be elucidated. The aim was to investigate the associations between habitual intake of fat- and water-soluble vitamins/vitamers and markers of glucose metabolism (fasting plasma glucose (FPG), homeostasis model assessment insulin resistance (HOMA-IR) index, and homeostasis model assessment β-cell function (HOMA-β)) in individuals after AP. A total of 106 participants after AP were included in this cross-sectional study and were grouped based on glycaemic status: new-onset prediabetes/diabetes after AP (NODAP), pre-existing prediabetes/type 2 diabetes (T2DM), and normoglycaemia after AP (NAP). Habitual intake of seven fat-soluble vitamins/vitamers and seven water-soluble vitamins were determined by the EPIC-Norfolk food frequency questionnaire. Multiple linear regression analyses were conducted using five statistical models built to adjust for covariates (age, sex, daily energy intake, visceral/subcutaneous fat volume ratio, smoking status, daily alcohol intake, aetiology of AP, number of AP episodes, cholecystectomy, and use of antidiabetic medications). In the NODAP group, three fat-soluble vitamins/vitamers (α-carotene, β-carotene, and total carotene) were significantly associated with HOMA-β. One water-soluble vitamin (vitamin B3) was also significantly associated with HOMA-β in the NODAP group. None of the studied vitamins were significantly associated with FPG or HOMA-IR in the NODAP group. Prospective longitudinal studies and randomised controlled trials are now warranted to investigate if the observed associations between vitamin/vitamer intake and NODAP are causal and to unveil the specific mechanisms underlying their involvement with NODAP. |
| first_indexed | 2024-03-09T11:32:13Z |
| format | Article |
| id | doaj.art-08855701d16b4935b6288967ee8d88c1 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T11:32:13Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-08855701d16b4935b6288967ee8d88c12023-11-30T23:48:50ZengMDPI AGNutrients2072-66432022-04-01147148010.3390/nu14071480Relationship between Habitual Intake of Vitamins and New-Onset Prediabetes/Diabetes after Acute PancreatitisClaire F. Norbitt0Wandia Kimita1Sakina H. Bharmal2Juyeon Ko3Maxim S. Petrov4School of Medicine, University of Auckland, Auckland 1023, New ZealandSchool of Medicine, University of Auckland, Auckland 1023, New ZealandSchool of Medicine, University of Auckland, Auckland 1023, New ZealandSchool of Medicine, University of Auckland, Auckland 1023, New ZealandSchool of Medicine, University of Auckland, Auckland 1023, New ZealandVitamins have many established roles in human health. However, the role of habitual dietary intake of vitamins in glucose homeostasis in individuals after acute pancreatitis (AP) is yet to be elucidated. The aim was to investigate the associations between habitual intake of fat- and water-soluble vitamins/vitamers and markers of glucose metabolism (fasting plasma glucose (FPG), homeostasis model assessment insulin resistance (HOMA-IR) index, and homeostasis model assessment β-cell function (HOMA-β)) in individuals after AP. A total of 106 participants after AP were included in this cross-sectional study and were grouped based on glycaemic status: new-onset prediabetes/diabetes after AP (NODAP), pre-existing prediabetes/type 2 diabetes (T2DM), and normoglycaemia after AP (NAP). Habitual intake of seven fat-soluble vitamins/vitamers and seven water-soluble vitamins were determined by the EPIC-Norfolk food frequency questionnaire. Multiple linear regression analyses were conducted using five statistical models built to adjust for covariates (age, sex, daily energy intake, visceral/subcutaneous fat volume ratio, smoking status, daily alcohol intake, aetiology of AP, number of AP episodes, cholecystectomy, and use of antidiabetic medications). In the NODAP group, three fat-soluble vitamins/vitamers (α-carotene, β-carotene, and total carotene) were significantly associated with HOMA-β. One water-soluble vitamin (vitamin B3) was also significantly associated with HOMA-β in the NODAP group. None of the studied vitamins were significantly associated with FPG or HOMA-IR in the NODAP group. Prospective longitudinal studies and randomised controlled trials are now warranted to investigate if the observed associations between vitamin/vitamer intake and NODAP are causal and to unveil the specific mechanisms underlying their involvement with NODAP.https://www.mdpi.com/2072-6643/14/7/1480carotenoidsvitamin B3habitual vitamin intakeacute pancreatitisprediabetesdiabetes |
| spellingShingle | Claire F. Norbitt Wandia Kimita Sakina H. Bharmal Juyeon Ko Maxim S. Petrov Relationship between Habitual Intake of Vitamins and New-Onset Prediabetes/Diabetes after Acute Pancreatitis Nutrients carotenoids vitamin B3 habitual vitamin intake acute pancreatitis prediabetes diabetes |
| title | Relationship between Habitual Intake of Vitamins and New-Onset Prediabetes/Diabetes after Acute Pancreatitis |
| title_full | Relationship between Habitual Intake of Vitamins and New-Onset Prediabetes/Diabetes after Acute Pancreatitis |
| title_fullStr | Relationship between Habitual Intake of Vitamins and New-Onset Prediabetes/Diabetes after Acute Pancreatitis |
| title_full_unstemmed | Relationship between Habitual Intake of Vitamins and New-Onset Prediabetes/Diabetes after Acute Pancreatitis |
| title_short | Relationship between Habitual Intake of Vitamins and New-Onset Prediabetes/Diabetes after Acute Pancreatitis |
| title_sort | relationship between habitual intake of vitamins and new onset prediabetes diabetes after acute pancreatitis |
| topic | carotenoids vitamin B3 habitual vitamin intake acute pancreatitis prediabetes diabetes |
| url | https://www.mdpi.com/2072-6643/14/7/1480 |
| work_keys_str_mv | AT clairefnorbitt relationshipbetweenhabitualintakeofvitaminsandnewonsetprediabetesdiabetesafteracutepancreatitis AT wandiakimita relationshipbetweenhabitualintakeofvitaminsandnewonsetprediabetesdiabetesafteracutepancreatitis AT sakinahbharmal relationshipbetweenhabitualintakeofvitaminsandnewonsetprediabetesdiabetesafteracutepancreatitis AT juyeonko relationshipbetweenhabitualintakeofvitaminsandnewonsetprediabetesdiabetesafteracutepancreatitis AT maximspetrov relationshipbetweenhabitualintakeofvitaminsandnewonsetprediabetesdiabetesafteracutepancreatitis |