Comparison of remifentanil: Entonox with Entonox alone in labor analgesia
Background: We designed a study to evaluate the effectiveness of continuous low dose infusion of remifentanil adding to self-administration of entonox administered for pain relief during the active phase of first stage of labor. Materials and Methods: Thirty healthy term pregnant women recruited in...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2013-01-01
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| Series: | Advanced Biomedical Research |
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| Online Access: | http://www.advbiores.net/article.asp?issn=2277-9175;year=2013;volume=2;issue=1;spage=87;epage=87;aulast=Varposhti |
| _version_ | 1818021091096920064 |
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| author | Mojtaba Rahimi Varposhti Naghmeh Ahmadi Mehrdad Masoodifar Zahra Shahshahan Morteza Heydari Tabatabaie |
| author_facet | Mojtaba Rahimi Varposhti Naghmeh Ahmadi Mehrdad Masoodifar Zahra Shahshahan Morteza Heydari Tabatabaie |
| author_sort | Mojtaba Rahimi Varposhti |
| collection | DOAJ |
| description | Background: We designed a study to evaluate the effectiveness of continuous low dose infusion of remifentanil adding to self-administration of entonox administered for pain relief during the active phase of first stage of labor.
Materials and Methods: Thirty healthy term pregnant women recruited in our randomized double-blind, cross over study. They received the study medicines during two 30-min periods with a 15-min wash-out sequence after each period. Fifteen parturient used remifentanil as a single bolus dose followed by constant low dose infusion and self-administration of entonox (group R) during the first period and entonox and saline (group P) during the second period, while the remainder of the parturient used the drugs in a reverse order. Pain and Ramsay score, maternal and fetal hemodynamic, and ventilation were assessed during each intervention.
Results: In this study, mean pain severity scores were 8 ± 0.9 before and 5.4 ± 1.7 after intervention in group P, and 7.8 ± 0.1, 3.5 ± 1.3 in group R, respectively. Mean pain severity difference was 2.6 ± 1.5 in group P, while 4.3 ± 1.5 in group R; so, use of entonox and remifentanil can decrease labor pain two times more in comparison with entonox/placebo (normal saline). However, hemodynamic and ventilation parameter in remifentanil/entonox period were same as in entonox/placebo period. No statistical differences were seen in mean Ramsay score between group R and P. There was no episode of maternal bradycardia, hypotension, or hypoxemia.
Conclusion: Not only adding low dose infusion of remifentanil to self-administration of entonox was notable in labor pain reduction, it did n′t make more parturient and neonatal side-effects. |
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| format | Article |
| id | doaj.art-08862aea43a5477d8ed04582b783e17d |
| institution | Directory Open Access Journal |
| issn | 2277-9175 2277-9175 |
| language | English |
| last_indexed | 2024-04-14T08:13:21Z |
| publishDate | 2013-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Advanced Biomedical Research |
| spelling | doaj.art-08862aea43a5477d8ed04582b783e17d2022-12-22T02:04:28ZengWolters Kluwer Medknow PublicationsAdvanced Biomedical Research2277-91752277-91752013-01-0121878710.4103/2277-9175.122511Comparison of remifentanil: Entonox with Entonox alone in labor analgesiaMojtaba Rahimi VarposhtiNaghmeh AhmadiMehrdad MasoodifarZahra ShahshahanMorteza Heydari TabatabaieBackground: We designed a study to evaluate the effectiveness of continuous low dose infusion of remifentanil adding to self-administration of entonox administered for pain relief during the active phase of first stage of labor. Materials and Methods: Thirty healthy term pregnant women recruited in our randomized double-blind, cross over study. They received the study medicines during two 30-min periods with a 15-min wash-out sequence after each period. Fifteen parturient used remifentanil as a single bolus dose followed by constant low dose infusion and self-administration of entonox (group R) during the first period and entonox and saline (group P) during the second period, while the remainder of the parturient used the drugs in a reverse order. Pain and Ramsay score, maternal and fetal hemodynamic, and ventilation were assessed during each intervention. Results: In this study, mean pain severity scores were 8 ± 0.9 before and 5.4 ± 1.7 after intervention in group P, and 7.8 ± 0.1, 3.5 ± 1.3 in group R, respectively. Mean pain severity difference was 2.6 ± 1.5 in group P, while 4.3 ± 1.5 in group R; so, use of entonox and remifentanil can decrease labor pain two times more in comparison with entonox/placebo (normal saline). However, hemodynamic and ventilation parameter in remifentanil/entonox period were same as in entonox/placebo period. No statistical differences were seen in mean Ramsay score between group R and P. There was no episode of maternal bradycardia, hypotension, or hypoxemia. Conclusion: Not only adding low dose infusion of remifentanil to self-administration of entonox was notable in labor pain reduction, it did n′t make more parturient and neonatal side-effects.http://www.advbiores.net/article.asp?issn=2277-9175;year=2013;volume=2;issue=1;spage=87;epage=87;aulast=VarposhtiEntonoxlabor painremifentanil |
| spellingShingle | Mojtaba Rahimi Varposhti Naghmeh Ahmadi Mehrdad Masoodifar Zahra Shahshahan Morteza Heydari Tabatabaie Comparison of remifentanil: Entonox with Entonox alone in labor analgesia Advanced Biomedical Research Entonox labor pain remifentanil |
| title | Comparison of remifentanil: Entonox with Entonox alone in labor analgesia |
| title_full | Comparison of remifentanil: Entonox with Entonox alone in labor analgesia |
| title_fullStr | Comparison of remifentanil: Entonox with Entonox alone in labor analgesia |
| title_full_unstemmed | Comparison of remifentanil: Entonox with Entonox alone in labor analgesia |
| title_short | Comparison of remifentanil: Entonox with Entonox alone in labor analgesia |
| title_sort | comparison of remifentanil entonox with entonox alone in labor analgesia |
| topic | Entonox labor pain remifentanil |
| url | http://www.advbiores.net/article.asp?issn=2277-9175;year=2013;volume=2;issue=1;spage=87;epage=87;aulast=Varposhti |
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