Bioaccumulation and biochemical responses in the peppery furrow shell Scrobicularia plana exposed to a pharmaceutical cocktail at sub-lethal concentrations
Pharmaceutical drugs in the aquatic medium may pose significant risk to non-target organisms. In this study, the potential toxicity of a mixture of three compounds commonly detected in marine waters (ibuprofen, ciprofloxacin and flumequine) was assessed, by studying bioaccumulation, oxidative stress...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651322006856 |
| _version_ | 1811319805870866432 |
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| author | Chiara Trombini Julia Kazakova Mercedes Villar-Navarro Miriam Hampel Rut Fernández-Torres Miguel Ángel Bello-López Julián Blasco |
| author_facet | Chiara Trombini Julia Kazakova Mercedes Villar-Navarro Miriam Hampel Rut Fernández-Torres Miguel Ángel Bello-López Julián Blasco |
| author_sort | Chiara Trombini |
| collection | DOAJ |
| description | Pharmaceutical drugs in the aquatic medium may pose significant risk to non-target organisms. In this study, the potential toxicity of a mixture of three compounds commonly detected in marine waters (ibuprofen, ciprofloxacin and flumequine) was assessed, by studying bioaccumulation, oxidative stress and neurotoxicity parameters (catalase CAT, superoxide dismutase SOD, glutathione reductase GR, glutathione S-transferase GST, lipid peroxidation LPO, glutathione peroxidase GPX, metallothionein MT and acetylcholinesterase AChE) in the clam Scrobicularia plana. Temporal evolution of selected endpoints was evaluated throughout an exposure period (1, 7 and 21 days) followed by a depuration phase. The accumulation of all drugs was fast, however clams showed the ability to control the internal content of drugs, keeping their concentration constant throughout the exposure and reducing their content after 7 days of depuration. The induction of biochemical alterations (SOD, CAT, LPO, MT, AChE) was observed in gills and digestive gland probably related to an imbalance in the redox state of clams as a consequence of the exposure to the drug mixture. These alterations were also maintained at the end of the depuration week when the high levels of SOD, CAT, GST and LPO indicated the persistence of oxidative stress and damage to lipids despite the fact that clams were no longer exposed to the mixture. |
| first_indexed | 2024-04-13T12:48:55Z |
| format | Article |
| id | doaj.art-088711c1c83d4feaaa7ece52403998d9 |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-04-13T12:48:55Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-088711c1c83d4feaaa7ece52403998d92022-12-22T02:46:17ZengElsevierEcotoxicology and Environmental Safety0147-65132022-09-01242113845Bioaccumulation and biochemical responses in the peppery furrow shell Scrobicularia plana exposed to a pharmaceutical cocktail at sub-lethal concentrationsChiara Trombini0Julia Kazakova1Mercedes Villar-Navarro2Miriam Hampel3Rut Fernández-Torres4Miguel Ángel Bello-López5Julián Blasco6Department of Ecology and Coastal Management, Instituto de Ciencias Marinas de Andalucía (CSIC), Campus Rio San Pedro, 11510 Puerto Real, Cádiz, Spain; Corresponding author.Department of Analytical Chemistry, Faculty of Chemistry, Universidad de Sevilla, 41012, SpainDepartment of Analytical Chemistry, Faculty of Chemistry, Universidad de Sevilla, 41012, SpainInstituto Universitario de Investigación Marina (INMAR), Campus Rio San Pedro, 11510 Puerto Real, Cádiz, SpainDepartment of Analytical Chemistry, Faculty of Chemistry, Universidad de Sevilla, 41012, SpainDepartment of Analytical Chemistry, Faculty of Chemistry, Universidad de Sevilla, 41012, SpainDepartment of Ecology and Coastal Management, Instituto de Ciencias Marinas de Andalucía (CSIC), Campus Rio San Pedro, 11510 Puerto Real, Cádiz, SpainPharmaceutical drugs in the aquatic medium may pose significant risk to non-target organisms. In this study, the potential toxicity of a mixture of three compounds commonly detected in marine waters (ibuprofen, ciprofloxacin and flumequine) was assessed, by studying bioaccumulation, oxidative stress and neurotoxicity parameters (catalase CAT, superoxide dismutase SOD, glutathione reductase GR, glutathione S-transferase GST, lipid peroxidation LPO, glutathione peroxidase GPX, metallothionein MT and acetylcholinesterase AChE) in the clam Scrobicularia plana. Temporal evolution of selected endpoints was evaluated throughout an exposure period (1, 7 and 21 days) followed by a depuration phase. The accumulation of all drugs was fast, however clams showed the ability to control the internal content of drugs, keeping their concentration constant throughout the exposure and reducing their content after 7 days of depuration. The induction of biochemical alterations (SOD, CAT, LPO, MT, AChE) was observed in gills and digestive gland probably related to an imbalance in the redox state of clams as a consequence of the exposure to the drug mixture. These alterations were also maintained at the end of the depuration week when the high levels of SOD, CAT, GST and LPO indicated the persistence of oxidative stress and damage to lipids despite the fact that clams were no longer exposed to the mixture.http://www.sciencedirect.com/science/article/pii/S0147651322006856Scrobicularia planaPharmaceuticals mixtureBioaccumulationOxidative stressBiomarkers |
| spellingShingle | Chiara Trombini Julia Kazakova Mercedes Villar-Navarro Miriam Hampel Rut Fernández-Torres Miguel Ángel Bello-López Julián Blasco Bioaccumulation and biochemical responses in the peppery furrow shell Scrobicularia plana exposed to a pharmaceutical cocktail at sub-lethal concentrations Ecotoxicology and Environmental Safety Scrobicularia plana Pharmaceuticals mixture Bioaccumulation Oxidative stress Biomarkers |
| title | Bioaccumulation and biochemical responses in the peppery furrow shell Scrobicularia plana exposed to a pharmaceutical cocktail at sub-lethal concentrations |
| title_full | Bioaccumulation and biochemical responses in the peppery furrow shell Scrobicularia plana exposed to a pharmaceutical cocktail at sub-lethal concentrations |
| title_fullStr | Bioaccumulation and biochemical responses in the peppery furrow shell Scrobicularia plana exposed to a pharmaceutical cocktail at sub-lethal concentrations |
| title_full_unstemmed | Bioaccumulation and biochemical responses in the peppery furrow shell Scrobicularia plana exposed to a pharmaceutical cocktail at sub-lethal concentrations |
| title_short | Bioaccumulation and biochemical responses in the peppery furrow shell Scrobicularia plana exposed to a pharmaceutical cocktail at sub-lethal concentrations |
| title_sort | bioaccumulation and biochemical responses in the peppery furrow shell scrobicularia plana exposed to a pharmaceutical cocktail at sub lethal concentrations |
| topic | Scrobicularia plana Pharmaceuticals mixture Bioaccumulation Oxidative stress Biomarkers |
| url | http://www.sciencedirect.com/science/article/pii/S0147651322006856 |
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