Lamotrigine-induced hypersensitivity syndrome with histologic features of cd30+ lymphoma
Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome or drug-induced hypersensitivity syndrome (DIHS) is a severe adverse drug reaction. It can present with clinical, paraclinical, and histological findings mimicking skin and/or systemic lymphomas. We report the first case of a lamotri...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Indian Journal of Dermatology |
| Subjects: | |
| Online Access: | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2016;volume=61;issue=2;spage=235;epage=235;aulast=Stephan |
| _version_ | 1818131346524995584 |
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| author | Farid Stephan Roger Haber Elio Kechichian Francois Kamar |
| author_facet | Farid Stephan Roger Haber Elio Kechichian Francois Kamar |
| author_sort | Farid Stephan |
| collection | DOAJ |
| description | Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome or drug-induced hypersensitivity syndrome (DIHS) is a severe adverse drug reaction. It can present with clinical, paraclinical, and histological findings mimicking skin and/or systemic lymphomas. We report the first case of a lamotrigine-induced DRESS with histologic features of a cutaneous CD30+ lymphoma. The patient responded well to a tapering course of oral steroids. This case highlights the atypical presentation of a lamotrigine-induced DRESS/DIHS in the presence of a cutaneous and a lymph node CD30 + lymphocytic infiltrate mimicking systemic lymphoma. Pathologists and clinicians must be aware of this “lymphomatous” presentation of drug reactions. |
| first_indexed | 2024-12-11T08:19:29Z |
| format | Article |
| id | doaj.art-0888f89d92e64416b2f7ea4e761b2fe1 |
| institution | Directory Open Access Journal |
| issn | 0019-5154 1998-3611 |
| language | English |
| last_indexed | 2024-12-11T08:19:29Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dermatology |
| spelling | doaj.art-0888f89d92e64416b2f7ea4e761b2fe12022-12-22T01:14:41ZengWolters Kluwer Medknow PublicationsIndian Journal of Dermatology0019-51541998-36112016-01-0161223523510.4103/0019-5154.177784Lamotrigine-induced hypersensitivity syndrome with histologic features of cd30+ lymphomaFarid StephanRoger HaberElio KechichianFrancois KamarDrug rash with eosinophilia and systemic symptoms (DRESS) syndrome or drug-induced hypersensitivity syndrome (DIHS) is a severe adverse drug reaction. It can present with clinical, paraclinical, and histological findings mimicking skin and/or systemic lymphomas. We report the first case of a lamotrigine-induced DRESS with histologic features of a cutaneous CD30+ lymphoma. The patient responded well to a tapering course of oral steroids. This case highlights the atypical presentation of a lamotrigine-induced DRESS/DIHS in the presence of a cutaneous and a lymph node CD30 + lymphocytic infiltrate mimicking systemic lymphoma. Pathologists and clinicians must be aware of this “lymphomatous” presentation of drug reactions.http://www.e-ijd.org/article.asp?issn=0019-5154;year=2016;volume=61;issue=2;spage=235;epage=235;aulast=StephanDrug rash with eosinophilia and systemic symptomshypersensitivity syndromelamotriginelymphomapseudolymphoma |
| spellingShingle | Farid Stephan Roger Haber Elio Kechichian Francois Kamar Lamotrigine-induced hypersensitivity syndrome with histologic features of cd30+ lymphoma Indian Journal of Dermatology Drug rash with eosinophilia and systemic symptoms hypersensitivity syndrome lamotrigine lymphoma pseudolymphoma |
| title | Lamotrigine-induced hypersensitivity syndrome with histologic features of cd30+ lymphoma |
| title_full | Lamotrigine-induced hypersensitivity syndrome with histologic features of cd30+ lymphoma |
| title_fullStr | Lamotrigine-induced hypersensitivity syndrome with histologic features of cd30+ lymphoma |
| title_full_unstemmed | Lamotrigine-induced hypersensitivity syndrome with histologic features of cd30+ lymphoma |
| title_short | Lamotrigine-induced hypersensitivity syndrome with histologic features of cd30+ lymphoma |
| title_sort | lamotrigine induced hypersensitivity syndrome with histologic features of cd30 lymphoma |
| topic | Drug rash with eosinophilia and systemic symptoms hypersensitivity syndrome lamotrigine lymphoma pseudolymphoma |
| url | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2016;volume=61;issue=2;spage=235;epage=235;aulast=Stephan |
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