Primary Hepatosplenic Large B-Cell Lymphoma
Diffuse large B-cell lymphoma is the most common form of lymphoma. It usually begins in the lymph nodes; up to 40% may have an extranodal presentation. According to a definition of primary extranodal lymphoma with presentation only in extranodal sites, there are reports of large B-cell lymphomas lim...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2008-03-01
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| Series: | Case Reports in Gastroenterology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/120757 |
| _version_ | 1811269544110456832 |
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| author | M.R. Morales-Polanco R. Drijansky-Morgenstern E. Murillo-Meza E. Gómez-Morales |
| author_facet | M.R. Morales-Polanco R. Drijansky-Morgenstern E. Murillo-Meza E. Gómez-Morales |
| author_sort | M.R. Morales-Polanco |
| collection | DOAJ |
| description | Diffuse large B-cell lymphoma is the most common form of lymphoma. It usually begins in the lymph nodes; up to 40% may have an extranodal presentation. According to a definition of primary extranodal lymphoma with presentation only in extranodal sites, there are reports of large B-cell lymphomas limited to liver or spleen as separate entities, and to date there have been only three documented cases of primary hepatosplenic presentation. This paper reports a fourth case. Due to a review of the literature and the clinical course of the case reported, we conclude that primary hepatosplenic large B-cell lymphoma has been found predominantly in females older than 60 years. The patients reported had <2 months of evolution prior to diagnosis, prominent B symptoms, splenomegaly in three and hepatomegaly in two, none with lymph node involvement. All had thrombocytopenia and abnormal liver function tests; three had anemia and elevated serum lactic dehydrogenase levels, two with hemophagocytosis in bone marrow. Because of the previously mentioned data, it can be stated that primary hepatosplenic lymphoma is an uncommon and aggressive form of disease that requires immediate recognition and treatment. |
| first_indexed | 2024-04-12T21:45:01Z |
| format | Article |
| id | doaj.art-088b144607f741968593c438940d4cc4 |
| institution | Directory Open Access Journal |
| issn | 1662-0631 |
| language | English |
| last_indexed | 2024-04-12T21:45:01Z |
| publishDate | 2008-03-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Gastroenterology |
| spelling | doaj.art-088b144607f741968593c438940d4cc42022-12-22T03:15:40ZengKarger PublishersCase Reports in Gastroenterology1662-06312008-03-012110911510.1159/000120757120757Primary Hepatosplenic Large B-Cell LymphomaM.R. Morales-PolancoR. Drijansky-MorgensternE. Murillo-MezaE. Gómez-MoralesDiffuse large B-cell lymphoma is the most common form of lymphoma. It usually begins in the lymph nodes; up to 40% may have an extranodal presentation. According to a definition of primary extranodal lymphoma with presentation only in extranodal sites, there are reports of large B-cell lymphomas limited to liver or spleen as separate entities, and to date there have been only three documented cases of primary hepatosplenic presentation. This paper reports a fourth case. Due to a review of the literature and the clinical course of the case reported, we conclude that primary hepatosplenic large B-cell lymphoma has been found predominantly in females older than 60 years. The patients reported had <2 months of evolution prior to diagnosis, prominent B symptoms, splenomegaly in three and hepatomegaly in two, none with lymph node involvement. All had thrombocytopenia and abnormal liver function tests; three had anemia and elevated serum lactic dehydrogenase levels, two with hemophagocytosis in bone marrow. Because of the previously mentioned data, it can be stated that primary hepatosplenic lymphoma is an uncommon and aggressive form of disease that requires immediate recognition and treatment.http://www.karger.com/Article/FullText/120757Large B-cell lymphomaPrimary extranodal lymphomaHepatosplenic |
| spellingShingle | M.R. Morales-Polanco R. Drijansky-Morgenstern E. Murillo-Meza E. Gómez-Morales Primary Hepatosplenic Large B-Cell Lymphoma Case Reports in Gastroenterology Large B-cell lymphoma Primary extranodal lymphoma Hepatosplenic |
| title | Primary Hepatosplenic Large B-Cell Lymphoma |
| title_full | Primary Hepatosplenic Large B-Cell Lymphoma |
| title_fullStr | Primary Hepatosplenic Large B-Cell Lymphoma |
| title_full_unstemmed | Primary Hepatosplenic Large B-Cell Lymphoma |
| title_short | Primary Hepatosplenic Large B-Cell Lymphoma |
| title_sort | primary hepatosplenic large b cell lymphoma |
| topic | Large B-cell lymphoma Primary extranodal lymphoma Hepatosplenic |
| url | http://www.karger.com/Article/FullText/120757 |
| work_keys_str_mv | AT mrmoralespolanco primaryhepatospleniclargebcelllymphoma AT rdrijanskymorgenstern primaryhepatospleniclargebcelllymphoma AT emurillomeza primaryhepatospleniclargebcelllymphoma AT egomezmorales primaryhepatospleniclargebcelllymphoma |