Relation between histological prostatitis and lower urinary tract symptoms and erectile function
Background: Chronic prostatitis (CP) significantly worsens a patient's quality of life (QOL), but its etiology is heterogeneous. Although the inflammatory process must be associated with CP symptoms, not all patients with benign prostatic hyperplasia and histological prostatitis complain of CP...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-09-01
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| Series: | Prostate International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2287888217300089 |
| _version_ | 1797716904106786816 |
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| author | Taiki Mizuno Ippei Hiramatsu Yusuke Aoki Hirofumi Shimoyama Taiji Nozaki Masato Shirai Yan Lu Shigeo Horie Akira Tsujimura |
| author_facet | Taiki Mizuno Ippei Hiramatsu Yusuke Aoki Hirofumi Shimoyama Taiji Nozaki Masato Shirai Yan Lu Shigeo Horie Akira Tsujimura |
| author_sort | Taiki Mizuno |
| collection | DOAJ |
| description | Background: Chronic prostatitis (CP) significantly worsens a patient's quality of life (QOL), but its etiology is heterogeneous. Although the inflammatory process must be associated with CP symptoms, not all patients with benign prostatic hyperplasia and histological prostatitis complain of CP symptoms. The relation between the severity of histological inflammation and lower urinary tract symptoms (LUTS) and erectile function is not fully understood.
Methods: This study comprised 26 men with suspected prostate cancer but with no malignant lesion by pathological examination of prostate biopsy specimens. LUTS were assessed by several questionnaires including the International Prostate Symptom Score (IPSS), QOL index, Overactive Bladder Symptom Score (OABSS), and the National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI), and erectile function was assessed by the Sexual Health Inventory for Men. Prostate volume (PV) measured by transabdominal ultrasound, maximum flow rate by uroflowmetry, and serum concentration of prostate-specific antigen were also evaluated. All data collections were performed before prostate biopsy. Histological prostatitis was assessed by immunohistochemical staining with anti-CD45 antibody as the Quick score. The relation between the Quick score and several factors was assessed by Pearson correlation coefficient and a multivariate linear regression model after adjustment for PV.
Results: The Pearson correlation coefficient showed a correlation between the Quick score and several factors including PV, IPSS, QOL index, OABSS, and NIH-CPSI. A multivariate linear regression model after adjustment for PV showed only the NIH-CPSI to be associated with the Quick score. The relation between the Quick score and each domain score of the NIH-CPSI showed only the subscore of urinary symptoms to be an associated factor.
Conclusion: We found a correlation only between histological prostatitis and LUTS, but not erectile dysfunction. Especially, the subscore of urinary symptoms (residual feeling and urinary frequency) was associated with histological prostatitis. |
| first_indexed | 2024-03-12T08:28:23Z |
| format | Article |
| id | doaj.art-088bd6a1fdd34346941d2ff27639a6fb |
| institution | Directory Open Access Journal |
| issn | 2287-8882 |
| language | English |
| last_indexed | 2024-03-12T08:28:23Z |
| publishDate | 2017-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Prostate International |
| spelling | doaj.art-088bd6a1fdd34346941d2ff27639a6fb2023-09-02T17:53:05ZengElsevierProstate International2287-88822017-09-015311912310.1016/j.prnil.2017.04.001Relation between histological prostatitis and lower urinary tract symptoms and erectile functionTaiki Mizuno0Ippei Hiramatsu1Yusuke Aoki2Hirofumi Shimoyama3Taiji Nozaki4Masato Shirai5Yan Lu6Shigeo Horie7Akira Tsujimura8Department of Urology, Juntendo University Urayasu Hospital, Urayasu, JapanDepartment of Urology, Juntendo University Urayasu Hospital, Urayasu, JapanDepartment of Urology, Juntendo University Urayasu Hospital, Urayasu, JapanDepartment of Urology, Juntendo University Urayasu Hospital, Urayasu, JapanDepartment of Urology, Juntendo University Urayasu Hospital, Urayasu, JapanDepartment of Urology, Juntendo University Urayasu Hospital, Urayasu, JapanDepartment of Urology, Juntendo University Graduate School of Medicine, Tokyo, JapanDepartment of Urology, Juntendo University Graduate School of Medicine, Tokyo, JapanDepartment of Urology, Juntendo University Urayasu Hospital, Urayasu, JapanBackground: Chronic prostatitis (CP) significantly worsens a patient's quality of life (QOL), but its etiology is heterogeneous. Although the inflammatory process must be associated with CP symptoms, not all patients with benign prostatic hyperplasia and histological prostatitis complain of CP symptoms. The relation between the severity of histological inflammation and lower urinary tract symptoms (LUTS) and erectile function is not fully understood. Methods: This study comprised 26 men with suspected prostate cancer but with no malignant lesion by pathological examination of prostate biopsy specimens. LUTS were assessed by several questionnaires including the International Prostate Symptom Score (IPSS), QOL index, Overactive Bladder Symptom Score (OABSS), and the National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI), and erectile function was assessed by the Sexual Health Inventory for Men. Prostate volume (PV) measured by transabdominal ultrasound, maximum flow rate by uroflowmetry, and serum concentration of prostate-specific antigen were also evaluated. All data collections were performed before prostate biopsy. Histological prostatitis was assessed by immunohistochemical staining with anti-CD45 antibody as the Quick score. The relation between the Quick score and several factors was assessed by Pearson correlation coefficient and a multivariate linear regression model after adjustment for PV. Results: The Pearson correlation coefficient showed a correlation between the Quick score and several factors including PV, IPSS, QOL index, OABSS, and NIH-CPSI. A multivariate linear regression model after adjustment for PV showed only the NIH-CPSI to be associated with the Quick score. The relation between the Quick score and each domain score of the NIH-CPSI showed only the subscore of urinary symptoms to be an associated factor. Conclusion: We found a correlation only between histological prostatitis and LUTS, but not erectile dysfunction. Especially, the subscore of urinary symptoms (residual feeling and urinary frequency) was associated with histological prostatitis.http://www.sciencedirect.com/science/article/pii/S2287888217300089CD45Erectile FunctionHistological ProstatitisLower Urinary Tract Symptoms |
| spellingShingle | Taiki Mizuno Ippei Hiramatsu Yusuke Aoki Hirofumi Shimoyama Taiji Nozaki Masato Shirai Yan Lu Shigeo Horie Akira Tsujimura Relation between histological prostatitis and lower urinary tract symptoms and erectile function Prostate International CD45 Erectile Function Histological Prostatitis Lower Urinary Tract Symptoms |
| title | Relation between histological prostatitis and lower urinary tract symptoms and erectile function |
| title_full | Relation between histological prostatitis and lower urinary tract symptoms and erectile function |
| title_fullStr | Relation between histological prostatitis and lower urinary tract symptoms and erectile function |
| title_full_unstemmed | Relation between histological prostatitis and lower urinary tract symptoms and erectile function |
| title_short | Relation between histological prostatitis and lower urinary tract symptoms and erectile function |
| title_sort | relation between histological prostatitis and lower urinary tract symptoms and erectile function |
| topic | CD45 Erectile Function Histological Prostatitis Lower Urinary Tract Symptoms |
| url | http://www.sciencedirect.com/science/article/pii/S2287888217300089 |
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