CO2 Laser Therapy versus Cryotherapy in Treatment of Genital Warts: A Randomized Controlled Trial
Background: External genital warts are among the common causes of sexually transmitted diseases. Human papillomavirus is known as the main etiology of genital warts and the role of specific types of this virus in pathogenesis of cervical cancer has been recognized for decades. However, there are sti...
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2012-03-01
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| Series: | مجله دانشکده پزشکی اصفهان |
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| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/1739 |
| _version_ | 1827851187257344000 |
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| author | Mir Haddi Aziz Jalali Gholam Hossein Ghafarpour Babak Mousavifard |
| author_facet | Mir Haddi Aziz Jalali Gholam Hossein Ghafarpour Babak Mousavifard |
| author_sort | Mir Haddi Aziz Jalali |
| collection | DOAJ |
| description | Background: External genital warts are among the common causes of sexually transmitted diseases. Human papillomavirus is known as the main etiology of genital warts and the role of specific types of this virus in pathogenesis of cervical cancer has been recognized for decades. However, there are still many controversies regarding the best treatment of this infectious disease.
Methods: In this randomized controlled trial, 160 patients with genital warts were enrolled into the study. Eighty patients were treated with CO2 laser and 80 patients were treated with cryotherapy. They were evaluated for clearance rate, complications and recurrence rate during a 3-month follow-up period.
Findings: Seventy six lesions (95%) in CO2 laser therapy group and 37 lesions (46.2%) in cryotherapy group were completely cleared. The clearance rate was significantly different between groups (P < 0.001). 12% and 12.2% of the lesions in cryotherapy group required second and third applications to completely clear, respectively. However, in CO2 laser group, lesions just required one session of therapy to clear. The CO2 laser therapy was associated with less recurrence rate compared to the cryotherapy (0.05% vs. 0.18%).
Conclusion: The overall efficacy of CO2 laser in the treatment of external genital warts was approximately two-folds greater than that of cryotherapy. In addition, CO2 laser therapy was associated with lower recurrence rate than cryotherapy. |
| first_indexed | 2024-03-12T10:29:22Z |
| format | Article |
| id | doaj.art-088c66db15e74083a938302bf7c4f21f |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T10:29:22Z |
| publishDate | 2012-03-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-088c66db15e74083a938302bf7c4f21f2023-09-02T09:21:12ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2012-03-0129173909CO2 Laser Therapy versus Cryotherapy in Treatment of Genital Warts: A Randomized Controlled TrialMir Haddi Aziz Jalali0Gholam Hossein Ghafarpour1Babak Mousavifard2Associate Professor, Skin and Stem Cell Research Center, Department of Dermatology, Hazrat Rassoul Akram Hospital, Tehran University of Medical Sciences, Tehran ,IranAssociate Professor, Skin and Stem Cell Research Center, Department of Dermatology, Hazrat Rassoul Akram Hospital, Tehran University of Medical Sciences, Tehran ,IranStudent of Medicine, Skin Diseases and Leishmaniasis Research Center And Student Research Committee, Isfahan University of Medical Sciences, Isfahan And School of Medicine,Tehran University of Medical sciences, Tehran, IranBackground: External genital warts are among the common causes of sexually transmitted diseases. Human papillomavirus is known as the main etiology of genital warts and the role of specific types of this virus in pathogenesis of cervical cancer has been recognized for decades. However, there are still many controversies regarding the best treatment of this infectious disease. Methods: In this randomized controlled trial, 160 patients with genital warts were enrolled into the study. Eighty patients were treated with CO2 laser and 80 patients were treated with cryotherapy. They were evaluated for clearance rate, complications and recurrence rate during a 3-month follow-up period. Findings: Seventy six lesions (95%) in CO2 laser therapy group and 37 lesions (46.2%) in cryotherapy group were completely cleared. The clearance rate was significantly different between groups (P < 0.001). 12% and 12.2% of the lesions in cryotherapy group required second and third applications to completely clear, respectively. However, in CO2 laser group, lesions just required one session of therapy to clear. The CO2 laser therapy was associated with less recurrence rate compared to the cryotherapy (0.05% vs. 0.18%). Conclusion: The overall efficacy of CO2 laser in the treatment of external genital warts was approximately two-folds greater than that of cryotherapy. In addition, CO2 laser therapy was associated with lower recurrence rate than cryotherapy.http://jims.mui.ac.ir/index.php/jims/article/view/1739Genital wartsHuman papillomavirusCO2 laserCryotherapy |
| spellingShingle | Mir Haddi Aziz Jalali Gholam Hossein Ghafarpour Babak Mousavifard CO2 Laser Therapy versus Cryotherapy in Treatment of Genital Warts: A Randomized Controlled Trial مجله دانشکده پزشکی اصفهان Genital warts Human papillomavirus CO2 laser Cryotherapy |
| title | CO2 Laser Therapy versus Cryotherapy in Treatment of Genital Warts: A Randomized Controlled Trial |
| title_full | CO2 Laser Therapy versus Cryotherapy in Treatment of Genital Warts: A Randomized Controlled Trial |
| title_fullStr | CO2 Laser Therapy versus Cryotherapy in Treatment of Genital Warts: A Randomized Controlled Trial |
| title_full_unstemmed | CO2 Laser Therapy versus Cryotherapy in Treatment of Genital Warts: A Randomized Controlled Trial |
| title_short | CO2 Laser Therapy versus Cryotherapy in Treatment of Genital Warts: A Randomized Controlled Trial |
| title_sort | co2 laser therapy versus cryotherapy in treatment of genital warts a randomized controlled trial |
| topic | Genital warts Human papillomavirus CO2 laser Cryotherapy |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/1739 |
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