Increasing Notch signaling antagonizes PRC2-mediated silencing to promote reprograming of germ cells into neurons

Increasing Notch signaling antagonizes PRC2-mediated silencing to promote reprograming of germ cells into neurons

Cell-fate reprograming is at the heart of development, yet very little is known about the molecular mechanisms promoting or inhibiting reprograming in intact organisms. In the C. elegans germline, reprograming germ cells into somatic cells requires chromatin perturbation. Here, we describe that such...

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Bibliographic Details
Main Authors: Stefanie Seelk, Irene Adrian-Kalchhauser, Balázs Hargitai, Martina Hajduskova, Silvia Gutnik, Baris Tursun, Rafal Ciosk
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-09-01
Series:eLife
Subjects:
Notch
PRC2
reprograming
utx-1
glp-1
mes-2
Online Access:https://elifesciences.org/articles/15477

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