What is to be done when transient elastography is not feasible?
OBJECTIVES AND BACKGROUND The aim of this study was to find an alternative to Transient Elastography when its’ application is impossible or when no valid and reliable measurements can be obtained through its usage. MATERIALS AND METHODS Liver stiffness values were assessed with transient elas...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Victor Babes University of Medicine and Pharmacy Timisoara
2016-12-01
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| Series: | Research and Clinical Medicine |
| Subjects: | |
| Online Access: | http://www.resclinmed.eu/public/data_files/articles/46/article_46.pdf |
| _version_ | 1819160496219095040 |
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| author | Raluca Lupusoru Ioan Sporea¹, Alina Popescu Roxana Sirli¹, Mirela Danila¹, Radu Moleriu³ Claudia Zaharia³ |
| author_facet | Raluca Lupusoru Ioan Sporea¹, Alina Popescu Roxana Sirli¹, Mirela Danila¹, Radu Moleriu³ Claudia Zaharia³ |
| author_sort | Raluca Lupusoru |
| collection | DOAJ |
| description | OBJECTIVES AND BACKGROUND
The aim of this study was to find an alternative to
Transient Elastography when its’ application is impossible
or when no valid and reliable measurements can be
obtained through its usage.
MATERIALS AND METHODS
Liver stiffness values were assessed with transient
elastography [TE- (Fibroscan)], 2D shear wave
elastography (SuperSonic Shear Imaging-SSI) and point
shear wave elastography (pSWE) using VTQ and
ElastPQ, in a cohort of 90 patients with chronic liver
diseases. With the help of linear regression, we made a
multivariate analysis in order to test the relationship
between TE and the other three methods (ElastPQ, SSI,
VTQ). Given the very well correlated factors, we
consider them predictors for our model.
RESULTS
The model conducted with all the used factorsElastPQ+SSI+VTQ
compared with TE explained the
90.7% of the model variability (R=0.907). We tempted
the probability to exclude the factors one by one.
SSI+VTQ explained 90% of the model variability
(R=0.90). ElastPQ+VTQ explained 77% of the model
variability (R=0.77) and SSI+ElastPQ explained 89% of
the model variability (R=0.89).
CONCLUSIONS
SSI in combination with ElastPQ or VTQ is as good
as the TE single use. Therefore, these combinations can
be applied when TE can’t be performed or is not valid.
REFERENCES
1.Tsochatzis EA el al,.Elastography for the
diagnosis of severity of fibrosis in chronic liver disease: a
meta-analysis of diagnostic accuracy. J Hepatology.
2011;54:650-9.
2.Nierhoff J et.al . The efficiency of acoustic
radiation force imaging for the staging of liver fibrosis: a
meta-analysisEurRadiol. 2013;23:3040-53.
3.Ferraioli G et al. Performace of ElastPq Shear
Wave Elastography Technique for Assessing Fibrosis in
Chronic Vira Hepatitis. J. Hepatology. 2013;58:S7.
4.Herrmann E et al. 2D-shear wave elastography
is equivalent or superior to transient elastography for liver
fibrosis assessment: an individual patient data based
meta-analysis . EASL 2015 |
| first_indexed | 2024-12-22T16:57:22Z |
| format | Article |
| id | doaj.art-088d45d283934524a01c2869d3392aad |
| institution | Directory Open Access Journal |
| issn | 2360-1124 2537-5393 |
| language | English |
| last_indexed | 2024-12-22T16:57:22Z |
| publishDate | 2016-12-01 |
| publisher | Victor Babes University of Medicine and Pharmacy Timisoara |
| record_format | Article |
| series | Research and Clinical Medicine |
| spelling | doaj.art-088d45d283934524a01c2869d3392aad2022-12-21T18:19:24ZengVictor Babes University of Medicine and Pharmacy TimisoaraResearch and Clinical Medicine2360-11242537-53932016-12-01ISuppl.12525What is to be done when transient elastography is not feasible?Raluca Lupusoru0Ioan Sporea¹,1 Alina Popescu2Roxana Sirli¹,3 Mirela Danila¹, 4Radu Moleriu³5Claudia Zaharia³6¹Victor Babeș University of Medicine and Pharmacy, Department of Gastroenterology and Hepatology, Timișoara, Romania, Victor Babeș University of Medicine and Pharmacy, Department of Medical Informatics and Biostatistics, Timișoara, Romania¹Victor Babeș University of Medicine and Pharmacy, Department of Gastroenterology and Hepatology, Timișoara, Romania¹Victor Babeș University of Medicine and Pharmacy, Department of Gastroenterology and Hepatology, Timișoara, Romania¹Victor Babeș University of Medicine and Pharmacy, Department of Gastroenterology and Hepatology, Timișoara, Romania¹Victor Babeș University of Medicine and Pharmacy, Department of Gastroenterology and Hepatology, Timișoara, RomaniaTimișoara West University, Department of Mathematics, The Faculty of Mathematics and Informatics, Timișoara, RomaniaTimișoara West University, Department of Mathematics, The Faculty of Mathematics and Informatics, Timișoara, RomaniaOBJECTIVES AND BACKGROUND The aim of this study was to find an alternative to Transient Elastography when its’ application is impossible or when no valid and reliable measurements can be obtained through its usage. MATERIALS AND METHODS Liver stiffness values were assessed with transient elastography [TE- (Fibroscan)], 2D shear wave elastography (SuperSonic Shear Imaging-SSI) and point shear wave elastography (pSWE) using VTQ and ElastPQ, in a cohort of 90 patients with chronic liver diseases. With the help of linear regression, we made a multivariate analysis in order to test the relationship between TE and the other three methods (ElastPQ, SSI, VTQ). Given the very well correlated factors, we consider them predictors for our model. RESULTS The model conducted with all the used factorsElastPQ+SSI+VTQ compared with TE explained the 90.7% of the model variability (R=0.907). We tempted the probability to exclude the factors one by one. SSI+VTQ explained 90% of the model variability (R=0.90). ElastPQ+VTQ explained 77% of the model variability (R=0.77) and SSI+ElastPQ explained 89% of the model variability (R=0.89). CONCLUSIONS SSI in combination with ElastPQ or VTQ is as good as the TE single use. Therefore, these combinations can be applied when TE can’t be performed or is not valid. REFERENCES 1.Tsochatzis EA el al,.Elastography for the diagnosis of severity of fibrosis in chronic liver disease: a meta-analysis of diagnostic accuracy. J Hepatology. 2011;54:650-9. 2.Nierhoff J et.al . The efficiency of acoustic radiation force imaging for the staging of liver fibrosis: a meta-analysisEurRadiol. 2013;23:3040-53. 3.Ferraioli G et al. Performace of ElastPq Shear Wave Elastography Technique for Assessing Fibrosis in Chronic Vira Hepatitis. J. Hepatology. 2013;58:S7. 4.Herrmann E et al. 2D-shear wave elastography is equivalent or superior to transient elastography for liver fibrosis assessment: an individual patient data based meta-analysis . EASL 2015http://www.resclinmed.eu/public/data_files/articles/46/article_46.pdftransient elastographypoint elastography2DSWE elastographyliver fibrosis. |
| spellingShingle | Raluca Lupusoru Ioan Sporea¹, Alina Popescu Roxana Sirli¹, Mirela Danila¹, Radu Moleriu³ Claudia Zaharia³ What is to be done when transient elastography is not feasible? Research and Clinical Medicine transient elastography point elastography 2DSWE elastography liver fibrosis. |
| title | What is to be done when transient elastography is not feasible? |
| title_full | What is to be done when transient elastography is not feasible? |
| title_fullStr | What is to be done when transient elastography is not feasible? |
| title_full_unstemmed | What is to be done when transient elastography is not feasible? |
| title_short | What is to be done when transient elastography is not feasible? |
| title_sort | what is to be done when transient elastography is not feasible |
| topic | transient elastography point elastography 2DSWE elastography liver fibrosis. |
| url | http://www.resclinmed.eu/public/data_files/articles/46/article_46.pdf |
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