Inflammatory bowel disease and colorectal cancer
<p><strong>Background:</strong> Colorectal cancer is one of the most frequent cancers in developed countries and Slovenia, and the incidence is still rising. Groups of people with higher risk for colorectal cancer are well defined. Among them are patients with inflammatory bowel di...
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| Format: | Article |
| Language: | English |
| Published: |
Slovenian Medical Association
2006-12-01
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| Series: | Zdravniški Vestnik |
| Subjects: | |
| Online Access: | http://vestnik.szd.si/index.php/ZdravVest/article/view/2080 |
| _version_ | 1819261029039734784 |
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| author | Andreja Ocepek Pavel Skok |
| author_facet | Andreja Ocepek Pavel Skok |
| author_sort | Andreja Ocepek |
| collection | DOAJ |
| description | <p><strong>Background:</strong> Colorectal cancer is one of the most frequent cancers in developed countries and Slovenia, and the incidence is still rising. Groups of people with higher risk for colorectal cancer are well defined. Among them are patients with inflammatory bowel disease. The risk is highest in patients in whom whole large bowel is affected by inflammation, it rises after 8 to 10 years and increases with the duration of the disease. Precancerous lesion is a displastic, chronically inflammed mucosa and not an adenoma as in cases of sporadic colorectal carcinoma.</p><p><strong>Conclusions:</strong> Many studies suggest that the influence of genetic factors differs between sporadic and inflammatory bowel disease related colorectal cancer. Symptomatic patients at the time of diagnosis have a much worse prognosis. The goal of prevention programes is therefore discovering early precancerous lesions. Established screening protocols are based on relatively frequent colonoscopies which are inconvinient for the patient as well as the endoscopist. Use of specific genetic markers, mutations of candidate genes, as a screening method and a prognostic predictor could greatly lighten therapeutic decisions.</p> |
| first_indexed | 2024-12-23T19:35:18Z |
| format | Article |
| id | doaj.art-088e7ea123cc44f9884fcb51f98da7aa |
| institution | Directory Open Access Journal |
| issn | 1318-0347 1581-0224 |
| language | English |
| last_indexed | 2024-12-23T19:35:18Z |
| publishDate | 2006-12-01 |
| publisher | Slovenian Medical Association |
| record_format | Article |
| series | Zdravniški Vestnik |
| spelling | doaj.art-088e7ea123cc44f9884fcb51f98da7aa2022-12-21T17:33:48ZengSlovenian Medical AssociationZdravniški Vestnik1318-03471581-02242006-12-017501576Inflammatory bowel disease and colorectal cancerAndreja OcepekPavel Skok<p><strong>Background:</strong> Colorectal cancer is one of the most frequent cancers in developed countries and Slovenia, and the incidence is still rising. Groups of people with higher risk for colorectal cancer are well defined. Among them are patients with inflammatory bowel disease. The risk is highest in patients in whom whole large bowel is affected by inflammation, it rises after 8 to 10 years and increases with the duration of the disease. Precancerous lesion is a displastic, chronically inflammed mucosa and not an adenoma as in cases of sporadic colorectal carcinoma.</p><p><strong>Conclusions:</strong> Many studies suggest that the influence of genetic factors differs between sporadic and inflammatory bowel disease related colorectal cancer. Symptomatic patients at the time of diagnosis have a much worse prognosis. The goal of prevention programes is therefore discovering early precancerous lesions. Established screening protocols are based on relatively frequent colonoscopies which are inconvinient for the patient as well as the endoscopist. Use of specific genetic markers, mutations of candidate genes, as a screening method and a prognostic predictor could greatly lighten therapeutic decisions.</p>http://vestnik.szd.si/index.php/ZdravVest/article/view/2080inflammatory bowel diseaseCrohn’s diseaseulcerative colitiscolorectal cancergenetic markers |
| spellingShingle | Andreja Ocepek Pavel Skok Inflammatory bowel disease and colorectal cancer Zdravniški Vestnik inflammatory bowel disease Crohn’s disease ulcerative colitis colorectal cancer genetic markers |
| title | Inflammatory bowel disease and colorectal cancer |
| title_full | Inflammatory bowel disease and colorectal cancer |
| title_fullStr | Inflammatory bowel disease and colorectal cancer |
| title_full_unstemmed | Inflammatory bowel disease and colorectal cancer |
| title_short | Inflammatory bowel disease and colorectal cancer |
| title_sort | inflammatory bowel disease and colorectal cancer |
| topic | inflammatory bowel disease Crohn’s disease ulcerative colitis colorectal cancer genetic markers |
| url | http://vestnik.szd.si/index.php/ZdravVest/article/view/2080 |
| work_keys_str_mv | AT andrejaocepek inflammatoryboweldiseaseandcolorectalcancer AT pavelskok inflammatoryboweldiseaseandcolorectalcancer |