Predictive factors for the presence and long-term persistence of SARS-CoV-2 antibodies in healthcare and university workers
Abstract While patient groups at risk for severe COVID-19 infections are now well identified, the risk factors associated with SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) transmission and immunization are still poorly understood. In a cohort of staff members of a Belgian tertiary ac...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-13450-4 |
| _version_ | 1811242252733775872 |
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| author | Céline Grégoire Pascale Huynen Stéphanie Gofflot Laurence Seidel Nathalie Maes Laura Vranken Sandra Delcour Michel Moutschen Marie-Pierre Hayette Philippe Kolh Pierrette Melin Yves Beguin |
| author_facet | Céline Grégoire Pascale Huynen Stéphanie Gofflot Laurence Seidel Nathalie Maes Laura Vranken Sandra Delcour Michel Moutschen Marie-Pierre Hayette Philippe Kolh Pierrette Melin Yves Beguin |
| author_sort | Céline Grégoire |
| collection | DOAJ |
| description | Abstract While patient groups at risk for severe COVID-19 infections are now well identified, the risk factors associated with SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) transmission and immunization are still poorly understood. In a cohort of staff members of a Belgian tertiary academic hospital tested for SARS-CoV-2 antibodies during the early phase of the pandemic and followed-up after 6 weeks, 3 months and 10 months, we collected personal, occupational and medical data, as well as symptoms based on which we constructed a COVID-19 score. Seroprevalence was higher among participants in contact with patients or with COVID-19 confirmed subjects or, to a lesser extent, among those handling respiratory specimens, as well as among participants reporting an immunodeficiency or a previous or active hematological malignancy, and correlated with several symptoms. In multivariate analysis, variables associated with seropositivity were: contact with COVID-19 patients, immunodeficiency, previous or active hematological malignancy, anosmia, cough, nasal symptoms, myalgia, and fever. At 10 months, participants in contact with patients and those with higher initial COVID-19 scores were more likely to have sustained antibodies, whereas those with solid tumors or taking chronic medications were at higher risk to become seronegative. |
| first_indexed | 2024-04-12T13:48:59Z |
| format | Article |
| id | doaj.art-088ed67e10174e4699edc3d54d69f4cb |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T13:48:59Z |
| publishDate | 2022-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-088ed67e10174e4699edc3d54d69f4cb2022-12-22T03:30:35ZengNature PortfolioScientific Reports2045-23222022-06-011211810.1038/s41598-022-13450-4Predictive factors for the presence and long-term persistence of SARS-CoV-2 antibodies in healthcare and university workersCéline Grégoire0Pascale Huynen1Stéphanie Gofflot2Laurence Seidel3Nathalie Maes4Laura Vranken5Sandra Delcour6Michel Moutschen7Marie-Pierre Hayette8Philippe Kolh9Pierrette Melin10Yves Beguin11Division of Hematology, CHU Sart-TilmanDivision of Medical Microbiology, Unilab, CHU of LiègeBiothèque Hospitalo-Universitaire de Liège (BHUL), CHU of LiègeDepartment of Biostatistics and Medico-Economic Information, CHU of LiègeDepartment of Biostatistics and Medico-Economic Information, CHU of LiègeUnilab, CHU of LiègeUnilab, CHU of LiègeDivision of Infectious Diseases and General Internal Medicine, CHU of LiègeDivision of Medical Microbiology, Unilab, CHU of LiègeDepartment of Information System Management, CHU of LiègeDivision of Medical Microbiology, Unilab, CHU of LiègeDivision of Hematology, CHU Sart-TilmanAbstract While patient groups at risk for severe COVID-19 infections are now well identified, the risk factors associated with SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) transmission and immunization are still poorly understood. In a cohort of staff members of a Belgian tertiary academic hospital tested for SARS-CoV-2 antibodies during the early phase of the pandemic and followed-up after 6 weeks, 3 months and 10 months, we collected personal, occupational and medical data, as well as symptoms based on which we constructed a COVID-19 score. Seroprevalence was higher among participants in contact with patients or with COVID-19 confirmed subjects or, to a lesser extent, among those handling respiratory specimens, as well as among participants reporting an immunodeficiency or a previous or active hematological malignancy, and correlated with several symptoms. In multivariate analysis, variables associated with seropositivity were: contact with COVID-19 patients, immunodeficiency, previous or active hematological malignancy, anosmia, cough, nasal symptoms, myalgia, and fever. At 10 months, participants in contact with patients and those with higher initial COVID-19 scores were more likely to have sustained antibodies, whereas those with solid tumors or taking chronic medications were at higher risk to become seronegative.https://doi.org/10.1038/s41598-022-13450-4 |
| spellingShingle | Céline Grégoire Pascale Huynen Stéphanie Gofflot Laurence Seidel Nathalie Maes Laura Vranken Sandra Delcour Michel Moutschen Marie-Pierre Hayette Philippe Kolh Pierrette Melin Yves Beguin Predictive factors for the presence and long-term persistence of SARS-CoV-2 antibodies in healthcare and university workers Scientific Reports |
| title | Predictive factors for the presence and long-term persistence of SARS-CoV-2 antibodies in healthcare and university workers |
| title_full | Predictive factors for the presence and long-term persistence of SARS-CoV-2 antibodies in healthcare and university workers |
| title_fullStr | Predictive factors for the presence and long-term persistence of SARS-CoV-2 antibodies in healthcare and university workers |
| title_full_unstemmed | Predictive factors for the presence and long-term persistence of SARS-CoV-2 antibodies in healthcare and university workers |
| title_short | Predictive factors for the presence and long-term persistence of SARS-CoV-2 antibodies in healthcare and university workers |
| title_sort | predictive factors for the presence and long term persistence of sars cov 2 antibodies in healthcare and university workers |
| url | https://doi.org/10.1038/s41598-022-13450-4 |
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