Drugs to limit Zika virus infection and implication for maternal-fetal health
Although the placenta has robust defense mechanisms that protect the fetus from a viral infection, some viruses can manipulate or evade these mechanisms and disrupt physiology or cross the placental barrier. It is well established that the Zika virus is capable of vertical transmission from mother t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Virology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fviro.2022.928599/full |
| _version_ | 1811344160246988800 |
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| author | Ankur Kumar Ankur Kumar Deepak Kumar Joyce Jose Rajanish Giri Indira U. Mysorekar Indira U. Mysorekar |
| author_facet | Ankur Kumar Ankur Kumar Deepak Kumar Joyce Jose Rajanish Giri Indira U. Mysorekar Indira U. Mysorekar |
| author_sort | Ankur Kumar |
| collection | DOAJ |
| description | Although the placenta has robust defense mechanisms that protect the fetus from a viral infection, some viruses can manipulate or evade these mechanisms and disrupt physiology or cross the placental barrier. It is well established that the Zika virus is capable of vertical transmission from mother to fetus and can cause malformation of the fetal central nervous system (i.e., microcephaly), as well as Guillain-Barre syndrome in adults. This review seeks to gather and assess the contributions of translational research associated with Zika virus infection, including maternal-fetal vertical transmission of the virus. Nearly 200 inhibitors that have been evaluated in vivo and/or in vitro for their therapeutic properties against the Zika virus are summarized in this review. We also review the status of current vaccine candidates. Our main objective is to provide clinically relevant information that can guide future research directions and strategies for optimized treatment and preventive care of infections caused by Zika virus or similar pathogens. |
| first_indexed | 2024-04-13T19:42:50Z |
| format | Article |
| id | doaj.art-088fde0d239340a19407e23f58560d79 |
| institution | Directory Open Access Journal |
| issn | 2673-818X |
| language | English |
| last_indexed | 2024-04-13T19:42:50Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Virology |
| spelling | doaj.art-088fde0d239340a19407e23f58560d792022-12-22T02:32:50ZengFrontiers Media S.A.Frontiers in Virology2673-818X2022-08-01210.3389/fviro.2022.928599928599Drugs to limit Zika virus infection and implication for maternal-fetal healthAnkur Kumar0Ankur Kumar1Deepak Kumar2Joyce Jose3Rajanish Giri4Indira U. Mysorekar5Indira U. Mysorekar6Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX, United StatesSchool of Basic Sciences, Indian Institute of Technology Mandi, VPO-Kamand, Mandi, IndiaDepartment of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX, United StatesDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, State College, United StatesSchool of Basic Sciences, Indian Institute of Technology Mandi, VPO-Kamand, Mandi, IndiaDepartment of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX, United StatesDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United StatesAlthough the placenta has robust defense mechanisms that protect the fetus from a viral infection, some viruses can manipulate or evade these mechanisms and disrupt physiology or cross the placental barrier. It is well established that the Zika virus is capable of vertical transmission from mother to fetus and can cause malformation of the fetal central nervous system (i.e., microcephaly), as well as Guillain-Barre syndrome in adults. This review seeks to gather and assess the contributions of translational research associated with Zika virus infection, including maternal-fetal vertical transmission of the virus. Nearly 200 inhibitors that have been evaluated in vivo and/or in vitro for their therapeutic properties against the Zika virus are summarized in this review. We also review the status of current vaccine candidates. Our main objective is to provide clinically relevant information that can guide future research directions and strategies for optimized treatment and preventive care of infections caused by Zika virus or similar pathogens.https://www.frontiersin.org/articles/10.3389/fviro.2022.928599/fullpregnancyplacentavertical transmissionmicrocephalyNS2B proteaseNS3 |
| spellingShingle | Ankur Kumar Ankur Kumar Deepak Kumar Joyce Jose Rajanish Giri Indira U. Mysorekar Indira U. Mysorekar Drugs to limit Zika virus infection and implication for maternal-fetal health Frontiers in Virology pregnancy placenta vertical transmission microcephaly NS2B protease NS3 |
| title | Drugs to limit Zika virus infection and implication for maternal-fetal health |
| title_full | Drugs to limit Zika virus infection and implication for maternal-fetal health |
| title_fullStr | Drugs to limit Zika virus infection and implication for maternal-fetal health |
| title_full_unstemmed | Drugs to limit Zika virus infection and implication for maternal-fetal health |
| title_short | Drugs to limit Zika virus infection and implication for maternal-fetal health |
| title_sort | drugs to limit zika virus infection and implication for maternal fetal health |
| topic | pregnancy placenta vertical transmission microcephaly NS2B protease NS3 |
| url | https://www.frontiersin.org/articles/10.3389/fviro.2022.928599/full |
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