Unique case of inverted papilloma of septum with nasopharyngeal carcinoma: Is it a metachronous tumour?
Inverted papilloma is a rare and benign tumour. It affects the nasal cavity and paranasal sinuses, has a high rate of recurrence and is associated with malignant transformation. Only few cases of a poorly differentiated carcinoma arising from inverted papilloma have been reported, none of which in t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-05-01
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| Series: | SAGE Open Medical Case Reports |
| Online Access: | https://doi.org/10.1177/2050313X20922032 |
| _version_ | 1818885591685660672 |
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| author | Susanne Flach Aaron SJ Ferguson Sharon White Paul S White Jaiganesh Manickavasagam |
| author_facet | Susanne Flach Aaron SJ Ferguson Sharon White Paul S White Jaiganesh Manickavasagam |
| author_sort | Susanne Flach |
| collection | DOAJ |
| description | Inverted papilloma is a rare and benign tumour. It affects the nasal cavity and paranasal sinuses, has a high rate of recurrence and is associated with malignant transformation. Only few cases of a poorly differentiated carcinoma arising from inverted papilloma have been reported, none of which in the nasopharynx. We report a case of a 37-year-old female, who presented originally in 2012 with inverted papilloma of the nasal septum which was surgically resected. Nasopharyngeal biopsy from 2014 was reported as carcinoma in situ and treated with local endoscopic resection. Three years later she presented with a solitary lesion of the right Eustachian tube opening, confirmed as invasive poorly differentiated carcinoma. Imaging revealed T4 N2b M0 malignancy with skull base and prevertebral space invasion, likely extension into right temporal lobe and malignant adenopathy. Although rare, malignant transformation of inverted papilloma in unusual places should be considered during workup and monitoring of patients. |
| first_indexed | 2024-12-19T16:07:53Z |
| format | Article |
| id | doaj.art-0890cbebac47455fb6005584cda025f9 |
| institution | Directory Open Access Journal |
| issn | 2050-313X |
| language | English |
| last_indexed | 2024-12-19T16:07:53Z |
| publishDate | 2020-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medical Case Reports |
| spelling | doaj.art-0890cbebac47455fb6005584cda025f92022-12-21T20:14:48ZengSAGE PublishingSAGE Open Medical Case Reports2050-313X2020-05-01810.1177/2050313X20922032Unique case of inverted papilloma of septum with nasopharyngeal carcinoma: Is it a metachronous tumour?Susanne Flach0Aaron SJ Ferguson1Sharon White2Paul S White3Jaiganesh Manickavasagam4Department of Otorhinolaryngology and Head & Neck Surgery, Hospital of the Ludwig-Maximilians-University, Munich, GermanyDepartment of Otolaryngology and Head & Neck Surgery, Ninewells Hospital, Dundee, UKDepartment of Pathology, Ninewells Hospital, Dundee, UKDepartment of Otolaryngology and Head & Neck Surgery, Ninewells Hospital, Dundee, UKTayside Medical Science Centre, University of Dundee, Dundee, UKInverted papilloma is a rare and benign tumour. It affects the nasal cavity and paranasal sinuses, has a high rate of recurrence and is associated with malignant transformation. Only few cases of a poorly differentiated carcinoma arising from inverted papilloma have been reported, none of which in the nasopharynx. We report a case of a 37-year-old female, who presented originally in 2012 with inverted papilloma of the nasal septum which was surgically resected. Nasopharyngeal biopsy from 2014 was reported as carcinoma in situ and treated with local endoscopic resection. Three years later she presented with a solitary lesion of the right Eustachian tube opening, confirmed as invasive poorly differentiated carcinoma. Imaging revealed T4 N2b M0 malignancy with skull base and prevertebral space invasion, likely extension into right temporal lobe and malignant adenopathy. Although rare, malignant transformation of inverted papilloma in unusual places should be considered during workup and monitoring of patients.https://doi.org/10.1177/2050313X20922032 |
| spellingShingle | Susanne Flach Aaron SJ Ferguson Sharon White Paul S White Jaiganesh Manickavasagam Unique case of inverted papilloma of septum with nasopharyngeal carcinoma: Is it a metachronous tumour? SAGE Open Medical Case Reports |
| title | Unique case of inverted papilloma of septum with nasopharyngeal carcinoma: Is it a metachronous tumour? |
| title_full | Unique case of inverted papilloma of septum with nasopharyngeal carcinoma: Is it a metachronous tumour? |
| title_fullStr | Unique case of inverted papilloma of septum with nasopharyngeal carcinoma: Is it a metachronous tumour? |
| title_full_unstemmed | Unique case of inverted papilloma of septum with nasopharyngeal carcinoma: Is it a metachronous tumour? |
| title_short | Unique case of inverted papilloma of septum with nasopharyngeal carcinoma: Is it a metachronous tumour? |
| title_sort | unique case of inverted papilloma of septum with nasopharyngeal carcinoma is it a metachronous tumour |
| url | https://doi.org/10.1177/2050313X20922032 |
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