Rate of renal cell carcinoma subtypes in different races
PURPOSE: We sought to identify racial differences among histological subtypes of renal cell carcinoma (RCC) between black and non-black patients in an equal-access health care system. MATERIALS AND METHODS: We established a multi-institutional, prospective database of patients undergoing partial or...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Urologia
2011-02-01
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| Series: | International Brazilian Journal of Urology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382011000100004 |
| _version_ | 1818962261286322176 |
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| author | Alexander Sankin Jacob Cohen Hongbei Wang Richard J. Macchia Nicholas Karanikolas |
| author_facet | Alexander Sankin Jacob Cohen Hongbei Wang Richard J. Macchia Nicholas Karanikolas |
| author_sort | Alexander Sankin |
| collection | DOAJ |
| description | PURPOSE: We sought to identify racial differences among histological subtypes of renal cell carcinoma (RCC) between black and non-black patients in an equal-access health care system. MATERIALS AND METHODS: We established a multi-institutional, prospective database of patients undergoing partial or radical nephrectomy between January 1, 2000 and Sept 31, 2009. For the purposes of this study, data captured included age at diagnosis, race, tumor size, presence of lymphovascular invasion, presence of capsular invasion, margin status, and tumor histology. RESULTS: 204 kidney tumors were identified (Table-1). Of these, 117 (57.4%) were in black patients and 87 (42.6%) were in non-black patients. Age at surgery ranged from 37 to 87 with a median of 62. Tumor size ranged from 1.0 to 22.0 cm with a median of 5.0 cm. Overall, tumors were composed of clear cell RCC in 97 cases (47.5%), papillary RCC in 65 cases (31.9%), chromophobe RCC in 13 cases (6.4%), collecting duct/medullary RCC in 2 cases (1.0%), RCC with multiple histological subtypes in 8 cases (3.9%), malignant tumors of other origin in 6 cases (2.9%), and benign histology in 13 cases (6.4%). Among black patients, papillary RCC was seen in 56 cases (47.9%), compared to 9 cases (10.3%) among non-black patients (p < 0.001) (Table-2). Clear cell RCC was present in 38 (32.5%) of black patients and in 59 (67.8%) of non-blacks (p < 0.001). CONCLUSIONS: In our study, papillary RCC had a much higher occurrence among black patients compared to non-black patients. This is the first study to document such a great racial disparity among RCC subtypes. |
| first_indexed | 2024-12-20T12:26:31Z |
| format | Article |
| id | doaj.art-0892cd059d6746bfacd2bddeaee0ff62 |
| institution | Directory Open Access Journal |
| issn | 1677-5538 1677-6119 |
| language | English |
| last_indexed | 2024-12-20T12:26:31Z |
| publishDate | 2011-02-01 |
| publisher | Sociedade Brasileira de Urologia |
| record_format | Article |
| series | International Brazilian Journal of Urology |
| spelling | doaj.art-0892cd059d6746bfacd2bddeaee0ff622022-12-21T19:40:51ZengSociedade Brasileira de UrologiaInternational Brazilian Journal of Urology1677-55381677-61192011-02-01371293410.1590/S1677-55382011000100004Rate of renal cell carcinoma subtypes in different racesAlexander SankinJacob CohenHongbei WangRichard J. MacchiaNicholas KaranikolasPURPOSE: We sought to identify racial differences among histological subtypes of renal cell carcinoma (RCC) between black and non-black patients in an equal-access health care system. MATERIALS AND METHODS: We established a multi-institutional, prospective database of patients undergoing partial or radical nephrectomy between January 1, 2000 and Sept 31, 2009. For the purposes of this study, data captured included age at diagnosis, race, tumor size, presence of lymphovascular invasion, presence of capsular invasion, margin status, and tumor histology. RESULTS: 204 kidney tumors were identified (Table-1). Of these, 117 (57.4%) were in black patients and 87 (42.6%) were in non-black patients. Age at surgery ranged from 37 to 87 with a median of 62. Tumor size ranged from 1.0 to 22.0 cm with a median of 5.0 cm. Overall, tumors were composed of clear cell RCC in 97 cases (47.5%), papillary RCC in 65 cases (31.9%), chromophobe RCC in 13 cases (6.4%), collecting duct/medullary RCC in 2 cases (1.0%), RCC with multiple histological subtypes in 8 cases (3.9%), malignant tumors of other origin in 6 cases (2.9%), and benign histology in 13 cases (6.4%). Among black patients, papillary RCC was seen in 56 cases (47.9%), compared to 9 cases (10.3%) among non-black patients (p < 0.001) (Table-2). Clear cell RCC was present in 38 (32.5%) of black patients and in 59 (67.8%) of non-blacks (p < 0.001). CONCLUSIONS: In our study, papillary RCC had a much higher occurrence among black patients compared to non-black patients. This is the first study to document such a great racial disparity among RCC subtypes.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382011000100004kidney neoplasmrenal cellcarcinoma |
| spellingShingle | Alexander Sankin Jacob Cohen Hongbei Wang Richard J. Macchia Nicholas Karanikolas Rate of renal cell carcinoma subtypes in different races International Brazilian Journal of Urology kidney neoplasm renal cell carcinoma |
| title | Rate of renal cell carcinoma subtypes in different races |
| title_full | Rate of renal cell carcinoma subtypes in different races |
| title_fullStr | Rate of renal cell carcinoma subtypes in different races |
| title_full_unstemmed | Rate of renal cell carcinoma subtypes in different races |
| title_short | Rate of renal cell carcinoma subtypes in different races |
| title_sort | rate of renal cell carcinoma subtypes in different races |
| topic | kidney neoplasm renal cell carcinoma |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382011000100004 |
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