Fibroblast Growth Factor 2 Protein Stability Provides Decreased Dependence on Heparin for Induction of FGFR Signaling and Alters ERK Signaling Dynamics

Fibroblast Growth Factor 2 Protein Stability Provides Decreased Dependence on Heparin for Induction of FGFR Signaling and Alters ERK Signaling Dynamics

Fibroblast growth factor 2 (FGF2) plays important roles in tissue development and repair. Using heparan sulfates (HS)/heparin as a cofactor, FGF2 binds to FGF receptor (FGFR) and induces downstream signaling pathways, such as ERK pathway, that regulate cellular behavior. In most cell lines, FGF2 sig...

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Bibliographic Details
Main Authors: Zuzana Koledova, Jakub Sumbal, Anas Rabata, Gabin de La Bourdonnaye, Radka Chaloupkova, Barbara Hrdlickova, Jiri Damborsky, Veronika Stepankova
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
extracellular-signal-regulated kinase (ERK)
fibroblasts
fibroblast growth factor
fibroblast growth factor receptor
heparin
primary fibroblasts
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2019.00331/full

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