Nomogram Incorporating Contrast-Enhanced Ultrasonography Predicting Time to the Development of Castration-Resistant Prostate Cancer
Background: It is valuable to predict the time to the development of castration-resistant prostate cancer (CRPC) in patients with advanced prostate cancer (PCa). This study aimed to build and validate a nomogram incorporating the clinicopathologic characteristics and the parameters of contrast-enhan...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2021-10-01
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| Series: | Clinical Medicine Insights: Oncology |
| Online Access: | https://doi.org/10.1177/11795549211049750 |
| _version_ | 1818726222424702976 |
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| author | Yun-xin Zhao Guang-li Yao Jian Sun Xiao-lian Wang Ying Wang Qiu-qiong Cai Hui-li Kang Li-ping Gu Jia-shun Yu Wen-min Li Bei Zhang Jian Wang Jiang-jun Mei Yi Jiang |
| author_facet | Yun-xin Zhao Guang-li Yao Jian Sun Xiao-lian Wang Ying Wang Qiu-qiong Cai Hui-li Kang Li-ping Gu Jia-shun Yu Wen-min Li Bei Zhang Jian Wang Jiang-jun Mei Yi Jiang |
| author_sort | Yun-xin Zhao |
| collection | DOAJ |
| description | Background: It is valuable to predict the time to the development of castration-resistant prostate cancer (CRPC) in patients with advanced prostate cancer (PCa). This study aimed to build and validate a nomogram incorporating the clinicopathologic characteristics and the parameters of contrast-enhanced ultrasonography (CEUS) to predict the time to CRPC after androgen deprivation therapy (ADT). Methods: Patients with PCa were divided into the training (n = 183) and validation cohorts (n = 37) for nomogram construction and validation. The clinicopathologic characteristics and CEUS parameters were analyzed to determine the independent prognosis factors and serve as the basis of the nomogram to estimate the risk of 1-, 2-, and 3-year progress to CRPC. Results: T stage, distant metastasis, Gleason score, area under the curve (AUC), prostate-specific antigen (PSA) nadir, and time to PSA nadir were the independent predictors of CRPC (all P < 0.05). Three nomograms were built to predict the time to CRPC. Owing to the inclusion of CEUS parameter, the discrimination of the established nomogram (C-index: 0.825 and 0.797 for training and validation datasets) was improved compared with the traditional prediction model (C-index: 0.825 and 0.797), and when it excluded posttreatment PSA, it still obtained an acceptable discrimination (C-index: 0.825 and 0.797). Conclusions: The established nomogram including regular prognostic indicators and CEUS obtained an improved accuracy for the prediction of the time to CRPC. It was also applicable for early prediction of CRPC when it excluded posttreatment PSA, which might be helpful for individualized diagnosis and treatment. |
| first_indexed | 2024-12-17T21:54:46Z |
| format | Article |
| id | doaj.art-0897039db38f4140ac44d97385e2c3b6 |
| institution | Directory Open Access Journal |
| issn | 1179-5549 |
| language | English |
| last_indexed | 2024-12-17T21:54:46Z |
| publishDate | 2021-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical Medicine Insights: Oncology |
| spelling | doaj.art-0897039db38f4140ac44d97385e2c3b62022-12-21T21:31:09ZengSAGE PublishingClinical Medicine Insights: Oncology1179-55492021-10-011510.1177/11795549211049750Nomogram Incorporating Contrast-Enhanced Ultrasonography Predicting Time to the Development of Castration-Resistant Prostate CancerYun-xin Zhao0Guang-li Yao1Jian Sun2Xiao-lian Wang3Ying Wang4Qiu-qiong Cai5Hui-li Kang6Li-ping Gu7Jia-shun Yu8Wen-min Li9Bei Zhang10Jian Wang11Jiang-jun Mei12Yi Jiang13Department of Ultrasound, Shanghai Punan Hospital of Pudong New District, Shanghai, ChinaDepartment of Ultrasound, Shanghai Punan Hospital of Pudong New District, Shanghai, ChinaDepartment of Ultrasound, Shanghai Punan Hospital of Pudong New District, Shanghai, ChinaDepartment of Ultrasound, Shanghai Punan Hospital of Pudong New District, Shanghai, ChinaDepartment of Ultrasound, Shanghai Punan Hospital of Pudong New District, Shanghai, ChinaDepartment of Ultrasound, Shanghai Punan Hospital of Pudong New District, Shanghai, ChinaDepartment of Ultrasound, Shanghai Punan Hospital of Pudong New District, Shanghai, ChinaDepartment of Ultrasound, Shanghai Punan Hospital of Pudong New District, Shanghai, ChinaDepartment of Urology, Shanghai Punan Hospital of Pudong New District, Shanghai, ChinaDepartment of Urology, Shanghai Punan Hospital of Pudong New District, Shanghai, ChinaDepartment of Ultrasound, Shanghai Punan Hospital of Pudong New District, Shanghai, ChinaDepartment of Urology, Shanghai Punan Hospital of Pudong New District, Shanghai, ChinaDepartment of Ultrasound, Zhoupu Hospital, Shanghai Medical College, Shanghai, ChinaDepartment of Ultrasound, Shanghai Punan Hospital of Pudong New District, Shanghai, ChinaBackground: It is valuable to predict the time to the development of castration-resistant prostate cancer (CRPC) in patients with advanced prostate cancer (PCa). This study aimed to build and validate a nomogram incorporating the clinicopathologic characteristics and the parameters of contrast-enhanced ultrasonography (CEUS) to predict the time to CRPC after androgen deprivation therapy (ADT). Methods: Patients with PCa were divided into the training (n = 183) and validation cohorts (n = 37) for nomogram construction and validation. The clinicopathologic characteristics and CEUS parameters were analyzed to determine the independent prognosis factors and serve as the basis of the nomogram to estimate the risk of 1-, 2-, and 3-year progress to CRPC. Results: T stage, distant metastasis, Gleason score, area under the curve (AUC), prostate-specific antigen (PSA) nadir, and time to PSA nadir were the independent predictors of CRPC (all P < 0.05). Three nomograms were built to predict the time to CRPC. Owing to the inclusion of CEUS parameter, the discrimination of the established nomogram (C-index: 0.825 and 0.797 for training and validation datasets) was improved compared with the traditional prediction model (C-index: 0.825 and 0.797), and when it excluded posttreatment PSA, it still obtained an acceptable discrimination (C-index: 0.825 and 0.797). Conclusions: The established nomogram including regular prognostic indicators and CEUS obtained an improved accuracy for the prediction of the time to CRPC. It was also applicable for early prediction of CRPC when it excluded posttreatment PSA, which might be helpful for individualized diagnosis and treatment.https://doi.org/10.1177/11795549211049750 |
| spellingShingle | Yun-xin Zhao Guang-li Yao Jian Sun Xiao-lian Wang Ying Wang Qiu-qiong Cai Hui-li Kang Li-ping Gu Jia-shun Yu Wen-min Li Bei Zhang Jian Wang Jiang-jun Mei Yi Jiang Nomogram Incorporating Contrast-Enhanced Ultrasonography Predicting Time to the Development of Castration-Resistant Prostate Cancer Clinical Medicine Insights: Oncology |
| title | Nomogram Incorporating Contrast-Enhanced Ultrasonography Predicting Time to the Development of Castration-Resistant Prostate Cancer |
| title_full | Nomogram Incorporating Contrast-Enhanced Ultrasonography Predicting Time to the Development of Castration-Resistant Prostate Cancer |
| title_fullStr | Nomogram Incorporating Contrast-Enhanced Ultrasonography Predicting Time to the Development of Castration-Resistant Prostate Cancer |
| title_full_unstemmed | Nomogram Incorporating Contrast-Enhanced Ultrasonography Predicting Time to the Development of Castration-Resistant Prostate Cancer |
| title_short | Nomogram Incorporating Contrast-Enhanced Ultrasonography Predicting Time to the Development of Castration-Resistant Prostate Cancer |
| title_sort | nomogram incorporating contrast enhanced ultrasonography predicting time to the development of castration resistant prostate cancer |
| url | https://doi.org/10.1177/11795549211049750 |
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