Probiotics for the prevention of gestational diabetes mellitus: A meta-analysis of randomized controlled trials
Changes of intestinal microbiota have been shown to be involved in the development of gestational diabetes mellitus (GDM). We performed a meta-analysis to systematically evaluate the potential role of probiotics for the prevention of GDM. Systematic literature search was performed in electronic dat...
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| Format: | Article |
| Language: | English |
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2024-04-01
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| Series: | Biomolecules & Biomedicine |
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| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/10377 |
| _version_ | 1797193756005367808 |
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| author | Xue Li Luwen Zhang Yuanqi He Dandan Zhang Shihong Zhang |
| author_facet | Xue Li Luwen Zhang Yuanqi He Dandan Zhang Shihong Zhang |
| author_sort | Xue Li |
| collection | DOAJ |
| description |
Changes of intestinal microbiota have been shown to be involved in the development of gestational diabetes mellitus (GDM). We performed a meta-analysis to systematically evaluate the potential role of probiotics for the prevention of GDM. Systematic literature search was performed in electronic databases including PubMed, Cochrane library, Embase, Web of Science, Wanfang, and China National Knowledge Infrastructure (CNKI) to obtain relevant randomized controlled studies. A random-effects model was used to pool the results by incorporating the impact of the potential heterogeneity. Meta-regression and subgroup analyses were conducted to evaluate the source of heterogeneity. Fourteen studies involving 3527 pregnant women were included. Results showed that probiotics significantly reduced the incidence of GDM as compared to control (risk ratio [RR]: 0.71, 95% confidence interval [CI]: 0.52–0.96, P = 0.03) with significant heterogeneity (I2 = 73%). The meta-regression showed that body mass index (BMI) of females was positively associated with the RR for the effect of probiotics on GDM (coefficient = 0.084, P = 0.01). The results of subgroup analyses also suggested that probiotics significantly reduced the risk of GDM in women with BMI < 26 kg/m2, but not in those with BMI ≥ 26 kg/m2 (P for subgroup difference = 0.001). In addition, the preventative efficacy of probiotics on GDM was remarkable in women < 30 years, but not in those ≥ 30 years (P for subgroup difference < 0.001). In conclusion, probiotics may be effective in reducing the risk of GDM, particularly for females with lower BMI and younger age.
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| first_indexed | 2024-04-24T05:45:26Z |
| format | Article |
| id | doaj.art-08973530a89f40cda391d35d263ad9f3 |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T05:45:26Z |
| publishDate | 2024-04-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-08973530a89f40cda391d35d263ad9f32024-04-23T14:51:08ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2024-04-0110.17305/bb.2024.10377Probiotics for the prevention of gestational diabetes mellitus: A meta-analysis of randomized controlled trialsXue Li0Luwen Zhang1Yuanqi He2https://orcid.org/0009-0001-9175-7134Dandan Zhang3Shihong Zhang4Department of Obstetrics, Weihai Municipal Hospital, Cheeloo College of Medicine, Shandong University, Weihai, ChinaDepartment of Obstetrics, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Obstetrics, Weihai Municipal Hospital, Cheeloo College of Medicine, Shandong University, Weihai, ChinaDepartment of Obstetrics, Weihai Municipal Hospital, Cheeloo College of Medicine, Shandong University, Weihai, ChinaDepartment of Gynaecology and Obstetrics, Weihai Municipal Hospital, Cheeloo College of Medicine, Shandong University, Weihai, China Changes of intestinal microbiota have been shown to be involved in the development of gestational diabetes mellitus (GDM). We performed a meta-analysis to systematically evaluate the potential role of probiotics for the prevention of GDM. Systematic literature search was performed in electronic databases including PubMed, Cochrane library, Embase, Web of Science, Wanfang, and China National Knowledge Infrastructure (CNKI) to obtain relevant randomized controlled studies. A random-effects model was used to pool the results by incorporating the impact of the potential heterogeneity. Meta-regression and subgroup analyses were conducted to evaluate the source of heterogeneity. Fourteen studies involving 3527 pregnant women were included. Results showed that probiotics significantly reduced the incidence of GDM as compared to control (risk ratio [RR]: 0.71, 95% confidence interval [CI]: 0.52–0.96, P = 0.03) with significant heterogeneity (I2 = 73%). The meta-regression showed that body mass index (BMI) of females was positively associated with the RR for the effect of probiotics on GDM (coefficient = 0.084, P = 0.01). The results of subgroup analyses also suggested that probiotics significantly reduced the risk of GDM in women with BMI < 26 kg/m2, but not in those with BMI ≥ 26 kg/m2 (P for subgroup difference = 0.001). In addition, the preventative efficacy of probiotics on GDM was remarkable in women < 30 years, but not in those ≥ 30 years (P for subgroup difference < 0.001). In conclusion, probiotics may be effective in reducing the risk of GDM, particularly for females with lower BMI and younger age. https://www.bjbms.org/ojs/index.php/bjbms/article/view/10377Gestational diabetes mellitus (GDM)probioticsprevention strategiesincidencemeta-analysis |
| spellingShingle | Xue Li Luwen Zhang Yuanqi He Dandan Zhang Shihong Zhang Probiotics for the prevention of gestational diabetes mellitus: A meta-analysis of randomized controlled trials Biomolecules & Biomedicine Gestational diabetes mellitus (GDM) probiotics prevention strategies incidence meta-analysis |
| title | Probiotics for the prevention of gestational diabetes mellitus: A meta-analysis of randomized controlled trials |
| title_full | Probiotics for the prevention of gestational diabetes mellitus: A meta-analysis of randomized controlled trials |
| title_fullStr | Probiotics for the prevention of gestational diabetes mellitus: A meta-analysis of randomized controlled trials |
| title_full_unstemmed | Probiotics for the prevention of gestational diabetes mellitus: A meta-analysis of randomized controlled trials |
| title_short | Probiotics for the prevention of gestational diabetes mellitus: A meta-analysis of randomized controlled trials |
| title_sort | probiotics for the prevention of gestational diabetes mellitus a meta analysis of randomized controlled trials |
| topic | Gestational diabetes mellitus (GDM) probiotics prevention strategies incidence meta-analysis |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/10377 |
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