Autoimmunity is a hallmark of post-COVID syndrome
Abstract Autoimmunity has emerged as a characteristic of the post-COVID syndrome (PCS), which may be related to sex. In order to further investigate the relationship between SARS-CoV-2 and autoimmunity in PCS, a clinical and serological assessment on 100 patients was done. Serum antibody profiles ag...
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| Format: | Article |
| Language: | English |
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BMC
2022-03-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-022-03328-4 |
| _version_ | 1823945064869527552 |
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| author | Manuel Rojas Yhojan Rodríguez Yeny Acosta-Ampudia Diana M. Monsalve Chengsong Zhu Quan-Zhen Li Carolina Ramírez-Santana Juan-Manuel Anaya |
| author_facet | Manuel Rojas Yhojan Rodríguez Yeny Acosta-Ampudia Diana M. Monsalve Chengsong Zhu Quan-Zhen Li Carolina Ramírez-Santana Juan-Manuel Anaya |
| author_sort | Manuel Rojas |
| collection | DOAJ |
| description | Abstract Autoimmunity has emerged as a characteristic of the post-COVID syndrome (PCS), which may be related to sex. In order to further investigate the relationship between SARS-CoV-2 and autoimmunity in PCS, a clinical and serological assessment on 100 patients was done. Serum antibody profiles against self-antigens and infectious agents were evaluated by an antigen array chip for 116 IgG and 104 IgM antibodies. Thirty pre-pandemic healthy individuals were included as a control group. The median age of patients was 49 years (IQR: 37.8 to 55.3). There were 47 males. The median post-COVID time was 219 (IQR: 143 to 258) days. Latent autoimmunity and polyautoimmunity were found in 83% and 62% of patients, respectively. Three patients developed an overt autoimmune disease. IgG antibodies against IL-2, CD8B, and thyroglobulin were found in more than 10% of the patients. Other IgG autoantibodies, such as anti-interferons, were positive in 5–10% of patients. Anti-SARS-CoV-2 IgG antibodies were found in > 85% of patients and were positively correlated with autoantibodies, age, and body mass index (BMI). Few autoantibodies were influenced by age and BMI. There was no effect of gender on the over- or under-expression of autoantibodies. IgG anti-IFN-λ antibodies were associated with the persistence of respiratory symptoms. In summary, autoimmunity is characteristic of PCS, and latent autoimmunity correlates with humoral response to SARS-CoV-2. |
| first_indexed | 2024-12-17T08:17:26Z |
| format | Article |
| id | doaj.art-0899b56d3134457697930c51497c598a |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-12-17T08:17:26Z |
| publishDate | 2022-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-0899b56d3134457697930c51497c598a2022-12-21T21:57:01ZengBMCJournal of Translational Medicine1479-58762022-03-012011510.1186/s12967-022-03328-4Autoimmunity is a hallmark of post-COVID syndromeManuel Rojas0Yhojan Rodríguez1Yeny Acosta-Ampudia2Diana M. Monsalve3Chengsong Zhu4Quan-Zhen Li5Carolina Ramírez-Santana6Juan-Manuel Anaya7Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del RosarioCenter for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del RosarioCenter for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del RosarioCenter for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del RosarioDepartment of Immunology, Microarray & Immune Phenotyping Core Facility, University of Texas Southwestern Medical CenterDepartment of Immunology, Microarray & Immune Phenotyping Core Facility, University of Texas Southwestern Medical CenterCenter for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del RosarioCenter for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del RosarioAbstract Autoimmunity has emerged as a characteristic of the post-COVID syndrome (PCS), which may be related to sex. In order to further investigate the relationship between SARS-CoV-2 and autoimmunity in PCS, a clinical and serological assessment on 100 patients was done. Serum antibody profiles against self-antigens and infectious agents were evaluated by an antigen array chip for 116 IgG and 104 IgM antibodies. Thirty pre-pandemic healthy individuals were included as a control group. The median age of patients was 49 years (IQR: 37.8 to 55.3). There were 47 males. The median post-COVID time was 219 (IQR: 143 to 258) days. Latent autoimmunity and polyautoimmunity were found in 83% and 62% of patients, respectively. Three patients developed an overt autoimmune disease. IgG antibodies against IL-2, CD8B, and thyroglobulin were found in more than 10% of the patients. Other IgG autoantibodies, such as anti-interferons, were positive in 5–10% of patients. Anti-SARS-CoV-2 IgG antibodies were found in > 85% of patients and were positively correlated with autoantibodies, age, and body mass index (BMI). Few autoantibodies were influenced by age and BMI. There was no effect of gender on the over- or under-expression of autoantibodies. IgG anti-IFN-λ antibodies were associated with the persistence of respiratory symptoms. In summary, autoimmunity is characteristic of PCS, and latent autoimmunity correlates with humoral response to SARS-CoV-2.https://doi.org/10.1186/s12967-022-03328-4Post-COVID syndromePost-COVIDLong COVIDPost-acute COVID-19COVID-19Autoimmunity |
| spellingShingle | Manuel Rojas Yhojan Rodríguez Yeny Acosta-Ampudia Diana M. Monsalve Chengsong Zhu Quan-Zhen Li Carolina Ramírez-Santana Juan-Manuel Anaya Autoimmunity is a hallmark of post-COVID syndrome Journal of Translational Medicine Post-COVID syndrome Post-COVID Long COVID Post-acute COVID-19 COVID-19 Autoimmunity |
| title | Autoimmunity is a hallmark of post-COVID syndrome |
| title_full | Autoimmunity is a hallmark of post-COVID syndrome |
| title_fullStr | Autoimmunity is a hallmark of post-COVID syndrome |
| title_full_unstemmed | Autoimmunity is a hallmark of post-COVID syndrome |
| title_short | Autoimmunity is a hallmark of post-COVID syndrome |
| title_sort | autoimmunity is a hallmark of post covid syndrome |
| topic | Post-COVID syndrome Post-COVID Long COVID Post-acute COVID-19 COVID-19 Autoimmunity |
| url | https://doi.org/10.1186/s12967-022-03328-4 |
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